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Atypical erythrocytes and platelets in a patient with a pro-thrombin mutation
Prothrombin mutation G20210A, anti-phospholipid syndrome as well as iron overload has
previously been shown to cause thrombotic events. The main reason for this is the involvement
of these anomalies in causing hypercoagulability of the coagulation system, which frequently
leads to venous and arterial thrombotic events. We report the case of a 37-year-old white
female with prothrombin mutation G20210A, anti-phospholipid syndrome, as well as an
increased serum ferritin level, who experienced two transient ischemic attacks and suffers from
regular amaurosis fugax. We present an ultrastructural depiction of erythrocytes, platelets, and
the fibrin network, to explain the clinical manifestations of the thrombotic state seen in this
patient.