• Exploring mutual and exclusive biological information in cranial metric and morphological variables 

  Stull, Kyra Elizabeth; New, Briana T.; Corron, Louise K.; Auchter, Leah E.; Spradley, Kate; Wolfe, Christopher A.; Chu, Elaine Y.; Hefner, Joseph T. (University of Florida Press, 2024-07)

  Evidence suggests that both craniometric and cranial morphoscopic (MMS) traits elucidate information about cranial phenotypic variation and are appropriate proxies of genetic variation. Yet, the types of variation underlying ...
• Development and validation of a knowledge, attitudes and practices (KAP) questionnaire for healthcare professionals on environmental sustainability in healthcare in Southern Africa 

  Lister, Helga Elke; Mostert, Karien; Botha, Tanita; Field, Emma; Knock, Danté; Mubi, Natasha; Odendaal, Stefani; Rohde, Megan; Maric, Filip (F1000 Research Ltd, 2024-10)

  BACKGROUND: The triple planetary crisis of climate change, environmental pollution, and biodiversity loss is increasingly driving poor health outcomes worldwide. Healthcare systems and services are often not environmentally ...
• Women's experience of preterm birth in an East African context : a qualitative study 

  Habtu, Thomas Asmelash; Pembe, Andrea Barnabas; Chiwanga, Faraja S.; Odland, Jon Oyvind; Darj, Elisabeth (Makerere University, Medical School, 2024-03-01)

  BACKGROUND: Approximately 15 million children are born each year prematurely, representing more than 10 percent of all childbirths worldwide. Prematurity is an acute event and the leading cause of death among newborns and ...
• The integrated care costs of HIV and non-communicable diseases in South Africa 

  Moyo-Chilufya, Maureen; Mgutshini, Tennyson; Musekiwa, Alfred; Hongoro, Charles (International Union Against Tuberculosis and Lung Disease, 2024-12-01)

  SETTING: In sub-Saharan Africa, the syndemic of HIV and non-communicable diseases (NCDs) poses a significant challenge. To address this, leading global think tanks like the WHO advocate for integrated HIV/NCD care ...
• Comparing pill counts and patient self-reports versus DBS tenofovir concentrations as ART adherence measurements with virologic outcomes and HIV drug resistance in a cohort of adolescents and young adults failing ART in Harare, Zimbabwe 

  Mtisi, Takudzwa J.; Kouamou, Vinie; Morse, Gene D.; Dzinamarira, Tafadzwa; Ndhlovu, Chiratidzo E. (Elsevier, 2024-09)

  BACKGROUND : Monitoring adherence presents a challenge in adolescents and it is prudent to explore several options for determining their level of adherence. This study sought to determine ART adherence levels in adolescents ...
• Evaluating blood-brain barrier permeability, cytotoxicity, and activity of potential acetylcholinesterase inhibitors : in vitro and in silico study 

  Maboko, Lerato Mamabote; Theron, A.; Panayides, J._L.; Cordier, Werner; Fisher, D.; Steenkamp, Vanessa (Wiley, 2024-12)

  Acetylcholinesterase inhibitors (AChEIs) remain the first-line treatment for Alzheimer's disease. However, these drugs are largely symptomatic and often associated with adverse effects. This study aimed to evaluate novel ...
• Multi-target inhibitor CUDC-101 impairs DNA damage repair and enhances radiation response in triple-negative breast cell line 

  Seane, Elsie Neo; Nair, Shankari; Vandevoorde, Charlot; Bisio, Alessandra; Joubert, Anna Margaretha (MDPI, 2024-11-01)

  BACKGROUND : Since the discovery that Histone deacetylase inhibitors (HDCAi) could enhance radiation response, a number of HDACi, mainly pan-HDAC inhibitors, have been studied either as monotherapy or in combination with ...
• Mechanistic sequence of histone deacetylase inhibitors and radiation treatment : an overview 

  Seane, Elsie Neo; Nair, Shankari; Vandevoorde, Charlot; Joubert, Anna Margaretha (MDPI, 2024-05-08)

  Histone deacetylases inhibitors (HDACis) have shown promising therapeutic outcomes in haematological malignancies such as leukaemia, multiple myeloma, and lymphoma, with disappointing results in solid tumours when used ...
• Genetic variants associated with dengue hemorrhagic fever. A systematic review and meta-analysis 

  Kanan, Mohammed; Naffaa, Mohammed; Alanazi, Ahmed; Nasser, Faiz; Alsaiari, Ahad Amer; Almehmadi, Mazen; Assiry, Ali; Muzafar, Hisham; Katam, Hejab; Arar, Abdullah; Asdaq, Syed Mohammed Basheeruddin; Abida; Imran, Mohd.; Dzinamarira, Tafadzwa (Elsevier, 2024-04)

  Dengue hemorrhagic fever (DHF) is a severe condition resulting from the dengue virus, with four serotypes known as DEN-1, DEN-2, DEN-3, and DEN-4. Genetic variations play a crucial role in influencing susceptibility to ...
• Pro-inflammatory interactions of streptolysin O toxin with human neutrophils in vitro 

  Joseph, Darren; Theron, Annette J.; Feldman, C.; Anderson, Ronald; Tintinger, Gregory (Taylor and Francis Group, 2024-12)

  The recent global resurgence of severe infections caused by the Group A streptococcus (GAS) pathogen, Streptococcus pyogenes, has focused attention on this microbial pathogen, which produces an array of virulence factors, ...
• Insights into the value of the market for cocaine, heroin and methamphetamine in South Africa 

  Scheibe, Andrew; Shelly, Shaun; Stowe, M.J. (LSE Press, 2024)

  The illicit drug trade generates billions of dollars and sustains transnational criminal organisations. Drug markets can destabilise governance and undermine development. Data indicate increasing drug use in South Africa. ...
• Enteropathogenic viruses associated with acute gastroenteritis among African children under 5 years of age 

  Omatola, Cornelius Arome; Ogunsakin, Ropo Ebenezer; Onoja, Anyebe Bernard; Okolo, Martin-Luther Oseni; Abraham-Oyiguh, Joseph; Mofolorunsho, Kehinde Charles; Akoh, Phoebe Queen; Adejo, Omebije Patience; Idakwo, Joshua; Okeme, Therisa Ojomideju; Muhammed, Danjuma; Adaji, David Moses; Samson, Sunday Ocholi; Aminu, Ruth Foluke; Akor, Monday Eneojo; Edegbo, Emmanuel; Adamu, Andrew Musa (Elsevier, 2024-06)

  Gastroenteritis viruses are the leading etiologic agents of diarrhea in children worldwide. We present data from thirty-three (33) eligible studies published between 2003 and 2023 from African countries bearing the brunt ...
• Mortality trends and causes of death in a South African hospital complex pre- and during COVID-19 

  Tshabalala, Khanyisile; Fabris-Rotelli, Inger Nicolette; Basu, Debashis; Myburgh, Magriet; Abdullah, Fareed (AOSIS, 2025-03)

  BACKGROUND : Before coronavirus disease 2019 (COVID-19), global health was improving, with declining mortality trends. The pandemic disrupted this progress, increasing mortality in South Africa between April 2020 and ...
• Adherence, perceptions and knowledge of an HIV PMTCT programme : a mother-baby pair study 

  Mabuka, Sthembiso; Lowane, Mygirl P.; Nesengani, Tintswalo Victoria; Simbeni, Thembi V. (AOSIS, 2025-01)

  BACKGROUND : Prevention of mother-to-child transmission (PMTCT) programmes are designed to prevent HIV transmission to infants and children. Despite efforts to achieve this goal, several factors continue to pose ...
• Acceptability and safety of thermal ablation treatment for cervical cytological abnormalities in Pretoria, South Africa 

  Malaza, C.K.; Dreyer, Greta; Snyman, Leon Cornelius; Visser, Cathy; Buchmann, E.J. (Medpharm Publications, 2025-02)

  BACKGROUND : Cervical cancer is one of the leading causes of cancer deaths in women, and 90% of the deaths occur in low- to middle-income countries (LMICs). Accessible cervical cancer screening and treatment options are ...
• The importance of critical incident reporting in anaesthesia 

  Dippenaar, Johannes Marthinus (Tinus) (Medpharm Publications, 2025-02-28)

  As a cornerstone of modern surgical and perioperative practice, anaesthesiologists are tasked with ensuring patient comfort and procedural safety during the perioperative period. Anaesthesia, however, remains a high-risk ...
• Editorial : Social determinants of health for the global aging population in pandemic and disaster environments 

  Levy-Storms, Lene; Lee, Soohyoung Rain; Castelyn, C. de Villebois; Morrissey, Mary Beth; Ory, Marcia G. (Frontiers Media, 2025-02)

  This Research Topic offers insights into various social determinants of health among older adults across the world, particularly in the context of pandemics and disaster environments. In this Research Topic, health is ...
• Effective cervical cancer prevention in sub-Saharan Africa needs the inclusion of men as key stakeholders 

  Dzobo, Mathias; Dzinamarira, Tafadzwa (Frontiers Media, 2025-01)

  Cervical cancer is a major public health problem in low-middle-income countries, especially in sub-Saharan Africa. Strategies for cervical cancer prevention are multi-sectorial, often involving many stakeholders. However, ...
• Global prevalence, resistance rates, and underlying resistance mechanisms of clinical Mycoplasma and Ureaplasma species 

  Ramaloko, Winnie Thabisa; Maningi, Nontuthuko Excellent; Osei Sekyere, John (Oxford University Press, 2025-01)

  Mycoplasmas are significant pathogens in human health, implicated in a range of clinical conditions from respiratory infections to urogenital disorders. Their resistance to commonly used antibiotics poses a substantial ...
• High prevalence of reverse transcriptase inhibitors associated resistance mutations among people living with HIV on dolutegravir-based antiretroviral therapy in Francistown, Botswana 

  Choga, Ontlametse T.; Lemogang, Goitseone M.; Choga, Wonderful T.; Muzanywa, Gaonyadiwe; Shadreck, Thembinkosi M.; Ralegoreng, Charity; Maruapula, Dorcas; Moraka, Natasha O.; Koofhethile, Catherine K.; Mokgethi, Patrick T.; Seru, Kedumetse; Zuze, Boitumelo J.L.; Montshosi, Patience; Gobe, Irene; Motswaledi, Modisa S.; Musonda, Rosemary; Mbulawa, Mpaphi B.; Makhema, Joseph; Shapiro, Roger; Lockman, Shahin; Chebani, Tony; Nawa, Judith; Bochena, Lindani; Moyo, Sikhulile; Gaseitsiwe, Simani (Oxford University Press, 2025-03)

  OBJECTIVES : We assessed HIV-1 drug resistance profiles among people living with HIV (PLWH) with detectable viral load (VL) and on dolutegravir-based antiretroviral therapy (ART) in Botswana. METHODS : The study utilised ...

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