• Multi-target inhibitor CUDC-101 impairs DNA damage repair and enhances radiation response in triple-negative breast cell line 

  Seane, Elsie Neo; Nair, Shankari; Vandevoorde, Charlot; Bisio, Alessandra; Joubert, Anna Margaretha (MDPI, 2024-11-01)

  BACKGROUND : Since the discovery that Histone deacetylase inhibitors (HDCAi) could enhance radiation response, a number of HDACi, mainly pan-HDAC inhibitors, have been studied either as monotherapy or in combination with ...
• Mechanistic sequence of histone deacetylase inhibitors and radiation treatment : an overview 

  Seane, Elsie Neo; Nair, Shankari; Vandevoorde, Charlot; Joubert, Anna Margaretha (MDPI, 2024-05-08)

  Histone deacetylases inhibitors (HDACis) have shown promising therapeutic outcomes in haematological malignancies such as leukaemia, multiple myeloma, and lymphoma, with disappointing results in solid tumours when used ...
• PhysioCAFUN : a competency-based curriculum development guideline to strengthen physiology education in Africa 

  Alagbonsi, Abdullateef Isiaka; Essop, M. Faadiel; El-Wazir, Yasser; Nyakudya, Trevor Tapiwa; Fastone, Goma; Mojiminiyi, Frank; Saeed, Amal; Stienen, Ger J.M.; Balandya, Emmanuel; Raji, Yinusa; Bintou Sarr, Fatou; Samb, Abdoulaye; Ebrahim, Ashabilan; Pohl, Ulrich; Silverthorn, Dee U. (American Physiological Society, 2025-03)

  Physiology education in Africa faces challenges due to gaps in curricula across many of its universities, such as divergent content, a lack of standardized competencies, and suitable benchmarking. Here, we describe the ...
• Number of symptoms during the acute phase of SARS-CoV-2 infection in athletes is associated with multiorgan involvement : AWARE III 

  Snyders, Carolette; Dyer, Marlise; Jordaan, Esme; Scholtz, Leonie; Du Plessis, Andre; Mpe, Martin; Kaulback, Kelly; Schwellnus, Martin Peter (Lippincott Williams and Wilkins, 2025)

  OBJECTIVE : Acute respiratory infections (ARinf), including SARS-CoV-2 infection, can affect multiple organ systems that may influence return to sport (RTS) in athletes. Factors associated with multiorgan involvement in ...
• COVID-19-induced diabetes mellitus : comprehensive cellular and molecular mechanistic insights 

  Nhau, Praise T.; Gamede, Mlindeli; Sibiya, Ntethelelo (MDPI, 2024-06)

  Despite evidence demonstrating the risks of developing diabetes mellitus because of SARSCoV-2, there is, however, insufficient scientific data available to elucidate the relationship between diabetes mellitus and COVID-19. ...
• Evaluation of [68Ga]Ga-DOTA-AeK as a potential imaging tool for PET imaging of cell wall synthesis in bacterial infections 

  Koatale, Palesa Caroline; Welling, Mick M.; Mdanda, Sipho; Mdlophane, Amanda; Takyi-Williams, John; Durandt, Chrisna; Van den Bout, Iman; Cleeren, Frederik; Sathekge, Mike Machaba; Ebenhan, Thomas (MDPI, 2024-09)

  Please read abstract in article.
• Identification of small-molecule antagonists targeting the growth hormone releasing hormone receptor (GHRHR) 

  Matsoukas, Minos-Timotheos; Radomsky, Tarryn; Panagiotopoulos, Vasilis; Du Preez, Robin; Papadourakis, Michail; Tsianakas, Konstantinos; Millar, Robert P.; Anderson, Ross Calley; Spyroulias, Georgios A.; Newton, Claire L. (American Chemical Society, 2024-08-29)

  The growth hormone-releasing hormone receptor (GHRHR) belongs to Class B1 of G protein-coupled receptors (GPCRs). Class B1 GPCR peptides such, as growth hormone-releasing hormone (GHRH), have been proposed to bind in a ...
• Obstructive sleep apnea screening protocol and safety measures : advancing treatment quality and reducing medical emergency team activation in patients with atrial fibrillation, respiratory diseases, and frailty 

  Otto, Monique (American Academy of Sleep Medicine, 2024-05)

  Despite ongoing research, the association of in-hospital medical emergency team activation (META) among patients with atrial fibrillation (AF) who are at risk for obstructive sleep apnea (OSA) is unclear. Using sleep ...
• The effects of exercise training as a treatment component of obstructive sleep apnea in diverse patient groups : current understanding and focus areas 

  Otto, Monique (American Academy of Sleep Medicine, 2024-11)

  It has been established that exercise is an essential component of obstructive sleep apnea (OSA) treatment. However, despite ongoing research and important findings reported in the last decade,1–17 the effects of exercise ...
• Rating of perceived exertion associated with acute symptoms in athletes with recent SARS-CoV-2 infection : athletes with acute respiratory infection (AWARE) VI study 

  Kaulback, Kelly; Schwellnus, Martin Peter; Sewry, Nicola; Jordaan, Esme; Wood, Paola (National Athletic Trainers' Association, 2024-01)

  CONTEXT : SARS-CoV-2 infection can affect the exercise response in athletes. Factors associated with the exercise response have not been reported. OBJECTIVE : To (1) describe heart rate (HR), systolic blood pressure ...
• Exploring the in vitro effects of Zingerone on differentiation and signalling pathways in bone cell lines 

  De Vos, Brunhildé; Kasonga, Abe E.; Joubert, Anna Margaretha; Nyakudya, Trevor Tapiwa (MDPI, 2024-12)

  Objective: Ensuring adequate bone health is crucial for preventing conditions such as osteoporosis and fractures. Zingerone, a phytonutrient isolated from cooked ginger, has gained attention for its potential benefits ...
• Glioblastoma cells alter brain endothelial cell homeostasis and tight junction protein expression in vitro 

  Mokoena, Xolisile; Mabeta, Peaceful Lucy; Cordier, Werner; Flepisi, Brian Thabile (Springer, 2025-01)

  BACKGROUND : Glioblastoma (GBM) is an aggressive therapy-resistant brain tumour that may impacts the integrity of the blood–brain barrier (BBB). The BBB is a protective barrier of the central nervous system formed mainly ...
• Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma 

  Duraj, Tomás; Kalamian, Miriam; Zuccoli, Giulio; Maroon, Joseph C.; D’Agostino, Dominic P.; Scheck, Adrienne C.; Poff, Angela; Winter, Sebastian F.; Hu, Jethro; Klement, Rainer J.; Hickson, Alicia; Lee, Derek C.; Cooper, Isabella; Kofler, Barbara; Schwartz, Kenneth A.; Phillips, Matthew C.L.; Champ, Colin E.; Zupec-Kania, Beth; Tan-Shalaby, Jocelyn; Serfaty, Fabiano M.; Omene, Egiroh; Arismendi-Morillo, Gabriel; Kiebish, Michael; Cheng, Richard; El-Sakka, Ahmed M.; Pflueger, Axel; Mathews, Edward H. (Eddie); Worden, Donese; Shi, Hanping; Cincione, Raffaele I.; Spinosa, Jean P.; Slocum, Abdul K.; Iyikesici, Mehmet S.; Yanagisawa, Atsuo; Pilkington, Geoffrey J.; Chaffee, Anthony; Abdel-Hadi, Wafaa; Elsamman, Amr K.; Klein, Pavel; Hagihara, Keisuke; Clemens, Zsófia; Yu, George W.; Evangeliou, Athanasios E.; Nathan, Janak K.; Smith, Kris; Fortin, David; Dietrich, Jorg; Mukherjee, Purna; Seyfried, Thomas N. (BioMed Central, 2024-12)

  Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a universally lethal prognosis despite maximal standard therapies. Here, we present a consensus treatment protocol based on the metabolic ...
• Investigation of neopterin and neurophysiological measurements as biomarkers of anxiety and stress 

  Cronje, Rouxzan; Beukes, Johanni; Masenge, Andries; Du Toit, P.J.; Bipath, Priyesh (International Society for Neurofeedback & Research, 2024-03-29)

  The aim of this study was to investigate whether the inflammatory marker neopterin and certain neurophysiological measurements could be used as complementary markers for stress and anxiety symptoms as determined by the ...
• Unveiling the link : the potential roles of vitamin D in keloid pathophysiology 

  Kotze, Jaco; Nortje, Evangeline; Phulukdaree, Alisa; Fear, Mark William; Wood, Fiona; Bester, Janette (Wiley, 2025-02)

  Keloid disease, a fibroproliferative skin disorder, is characterised by scar tissue growth that extends beyond the original wound boundaries. Despite advancements, current treatments, particularly surgical excision, often ...
• Development of water-soluble nanoformulations of novel pyrazolone derivatives and the evaluation of their antibacterial and antioxidant activities 

  Igbokwe, Nkeiruka N.; Ismail, Eman A.; Obakachi, Vincent A.; Ntsethe, Aviwe; Gamede, Mlindeli; Karpoormath, Rajshekhar; Faya, Mbuso A. (Springer, 2025-02)

  Poor aqueous solubility and stability hinder the clinical translation of pyrazolone-based derivatives despite their various biological activities. This study aimed to address these issues by developing water-soluble ...
• Health status of senior netball players, their medication use and attitudes towards doping 

  De Abreu, Micaela; Nolte, Kim; Janse van Rensburg, Dina Christina; Swart, Xan (Frontiers Media, 2024-09)

  Limited research exists on the health and injuries of South African senior netball players. Senior netball players may be at greater risk of injuries and chronic disease due to their age. To treat these conditions, they ...
• A highly sensitive RP HPLC-PDA analytical method for detection and quantification of a newly synthesized (E-2-((E)-4-(5-ethoxy-3-methyl-1-phenyl-1H-pyrazole-4-yl)but-3-en-2-ylidene)) hydrazine-1-carbothioamide in nanosuspension 

  Igbokwe, Nkeiruka N.; Ismail, Eman A.; Obakachi, Vincent A.; Gamede, Mlindeli; Karpoormath, Rajshekhar; Faya, Mbuso (Wiley, 2025-01)

  Analytical methods development and validation are vital for the precise detection, quantification, and characterization of novel therapeutic compounds, especially those with poor aqueous solubility, such as pyrazolone ...
• Protective effect of β-sitosterol against high-fructose diet-induced oxidative stress, and hepatorenal derangements in growing female Sprague-Dawley rats 

  Gumede, Nontobeko Myllet; Lembede, Busisani W.; Nkomozepi, Pilani; Brooksbank, Richard L.; Erlwanger, Kennedy H.; Chivandi, Eliton (BioMed Central, 2024-08-26)

  BACKGROUND Chronic consumption of a high-fructose diet causes oxidative stress that compromises kidney and liver health. β-sitosterol (Bst), a phytosterol, is a functional nutrient with health benefits. β-sitosterol ...
• The malaria burden : a South African perspective 

  Balmith, Marissa; Basson, Charlize; Brand, Sarel Jacobus (Wiley, 2024-02-23)

  Malaria is a deadly disease caused by protozoan pathogens of the Plasmodium parasite. Transmission to humans occurs through the bite of an infected female Anopheles mosquito. According to the World Health Organization ...

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