Comparison of the effects of macrolides, amoxicillin, ceftriaxone, doxycycline, tobramycin and fluoroquinolones, on the production of pneumolysin by Streptococcus pneumoniae in vitro

Anderson, Ronald; Steel, Helen C.; Cockeran, Riana; Von Gottberg, Anne; De Gouveia, L.; Klugman, Keith P.; Mitchell, Timothy J.; Feldman, Charles

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Comparison of the effects of macrolides, amoxicillin, ceftriaxone, doxycycline, tobramycin and fluoroquinolones, on the production of pneumolysin by Streptococcus pneumoniae in vitro

Anderson, Ronald; Steel, Helen C.; Cockeran, Riana; Von Gottberg, Anne; De Gouveia, L.; Klugman, Keith P.; Mitchell, Timothy J.; Feldman, Charles

URI: http://hdl.handle.net/2263/4329

Date: 2007-11

Abstract:

OBJECTIVES: To compare the effects of subinhibitory concentrations of amoxicillin, ceftriaxone, azithromycin, clarithromycin, erythromycin, telithromycin, clindamycin, ciprofloxacin, moxifloxacin, tobramycin and doxycycline on pneumolysin production by a macrolide-susceptible strain and two macrolide-resistant strains [erm(B) or mef(A)] of Streptococcus pneumoniae. METHODS: Please refer to abstract in article. RESULTS: Only the macrolides/macrolide-like agents caused significant attenuation of the production of pneumolysin, which was evident with all three strains of the pneumococcus. CONCLUSIONS: Macrolides, at sub-MICs, but not other classes of antibiotic, subvert the production of pneumolysin, even in the presence of (and irrespective of the mechanism of) macrolide resistance in S. pneumoniae.

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