• Characterization of plasmids mediating carbapenem resistance in Klebsiella pneumoniae in Pretoria, South Africa 

  Kopotsa, Katlego (University of Pretoria, 2020-01)

  pneumoniae is a Gram-negative bacterium belonging to the Enterobacteriaceae family. This pathogen is implicated in community- and hospital-acquired infections, particularly in neonates, the elderly, and immunocompromised ...
• Molecular characterisation of methicillin-resistant Staphylococcus aureus isolates associated with outbreaks in burn wound and neonatal ward patients at healthcare centres in Gauteng, South Africa 

  Gama, Keitumetse B. (University of Pretoria, 2019-12)

  Methicillin-resistant Staphylococcus aureus (MRSA) is one of the leading causes of nosocomial infections worldwide. It is an ESKAPE pathogen and is known for causing difficult-to-treat infections due to its antibiotic ...
• Antimicrobial resistance mechanisms of linezolid resistant staphylococci and enterococci collected in Gauteng, South Africa 

  Addison, Karen (University of Pretoria, 2019)

  Staphylococci and enterococci are key human pathogens responsible for infections associated with healthcare settings. Linezolid is crucial for managing multidrug-resistant (MDR) infections. The monitoring of resistance to ...
• Molecular epidemiology of Klebsiella pneumoniae isolates causing invasive disease from a private laboratory in South Africa 

  Liknaitzky, Sarah (University of Pretoria, 2024-06-07)

  Klebsiella pneumoniae (K. pneumoniae) is the most clinically significant species within the Klebsiella genus. The main burden of K. pneumoniae infections are healthcare-associated infections (HAIs), generally caused by the ...
• Molecular epidemiology of carbapenemase-producing Klebsiella pneumoniae isolates obtained from community-acquired urinary tract infections and rectal carriage isolates 

  Salvador-Oke, Kafilat Taiwo (University of Pretoria, 2023-11)

  Antimicrobial resistance (AMR) due to Enterobacterales is a worldwide public health threat. The continuous emergence of multidrug resistant (MDR) bacteria in developing countries with poor sanitation programmes, inactive ...
• One Health approach to investigate antimicrobial resistance and public health risk of foodborne pathogens in Gauteng and Limpopo provinces, South Africa 

  Ogundare, Samuel Tolulope (University of Pretoria, 2023-12)

  Globally, antimicrobial resistance (AMR) in foodborne pathogenic bacteria of the family Enterobacteriaceae has continued to rise. There is an increase in public health concerns about the spread of multi-drug resistant (MDR) ...
• Phenotypic and genotypic characterisation of clinically relevant Staphylococcus aureus isolates from cystic fibrosis patients from private clinics in South Africa 

  Ndlovu, Neliswa (University of Pretoria, 2024)

  Introduction. Cystic fibrosis is a hereditary disease that results in ineffective mucocilliary clearance of secretions, creating an environment that allows Staphylococcus aureus to thrive. The aim of this study was to ...
• Molecular epidemiology and treatment outcomes of vulvovaginal candidiasis in Namibian women 

  Dunaiski, Cara Mia (University of Pretoria, 2023-11-03)

  Vulvovaginal candidiasis (VVC) is a common condition in women of childbearing age worldwide and usually presents as vaginal discharge syndrome (VDS). Other important causes of VDS are bacterial vaginosis (BV) and sexually ...
• One Health approach investigating Shiga toxin-producing Escherichia coli serotypes from human stool specimens and cattle run-off water samples in South Africa 

  Bronkhorst, Shanerie (University of Pretoria, 2023)

  Shiga toxin-producing Escherichia coli (STEC) are known for producing cytotoxins called Shiga toxins and are prevalent in cattle. Data regarding the prevalence of STEC serotypes in South Africa is lacking. This study ...
• Antimicrobial, synergistic and autophagic effects of medicines for Malaria venture pathogen box compounds on resistant strains of Mycobacterium tuberculosis and Neisseria gonorrhoeae 

  Mensah, Eric (University of Pretoria, 2023)

  Antimicrobial resistance in Mycobacterium tuberculosis and Neisseria gonorrhoeae is emerging globally. Due to the limited treatment options, the World Health Organization has designated M. tuberculosis and N. gonorrhoeae ...
• Genotypic profiles of emerging multidrug-resistant Staphylococcus capitis isolates from an ongoing outbreak in critically ill patients 

  Mynhardt, Barend J. (University of Pretoria, 2023)

  An increasing number of linezolid resistant (LZR), multidrug-resistant (MDR) Staphylococcus capitis infections have been observed in private hospitals in the greater Gauteng area since 2014. The aim of this study was to ...
• Molecular characterisation of β-lactamase producing Klebsiella pneumoniae isolates 

  De Jesus, Marissa Batista (University of Pretoria, 2015)

  Genetic typing of Klebsiella pneumoniae is used for epidemiological referencing. In the clinical setting it can be useful in outbreak investigations, understanding transmission and managing hospital infections. Multi-drug ...
• Lung microbiome of chronic obstructive pulmonary disease patients with and without HIV infection in Pretoria, South Africa 

  Goolam Mahomed, Tanweer (University of Pretoria, 2020)

  Chronic obstructive pulmonary disease (COPD) is a leading cause of death and is highly prevalent in South Africa (19% in adults over the age of 40 years). Inflammation of the lungs in COPD impairs the immune response and ...
• Molecular epidemiology and mechanisms of colistin and carbapenem resistance in Enterobacteriaceae from clinical isolates, the environment and porcine samples in Pretoria, South Africa 

  Bogoshi, Dineo (University of Pretoria, 2020)

  Introduction: Carbapenems and colistin are the last-line antibiotics for treating Gram-negative bacterial infections. However, increasing reports of resistance to these antibiotics is being reported in clinical settings, ...
• Assessment of macrophage and granulocyte cell-enhanced phagocytosis of Mycobacterium tuberculosis 

  Shey, Bong-Akee (University of Pretoria, 2020)

  This study demonstrates the ability of a selected novel IgG1 mouse monoclonal antibody, JG7 III D3 I F9 (JG7), to enhance the phagocytic elimination (opsonophagocytosis) of susceptible M. tuberculosis strains at both their ...
• Phenotypic and genotypic characterization of isoniazid resistance mutations in Mycobacterium tuberculosis isolates from new and previously treated patients in the Tshwane region 

  Sinthumule, Ndivhudzannyi Peace (University of Pretoria, 2020)

  Background: Isoniazid (INH) is one of the most potent anti-tuberculosis (TB) drugs and a key component of the multi-drug regimen for the treatment of TB. Tuberculosis cases with initial INH resistance are more at risk ...
• Evaluation of single nucleotide polymorphisms in virulence genes of Mycobacterium tuberculosis as markers of lineages and sub-lineages in Tshwane region 

  Matodzi, Unarine (University of Pretoria, 2020)

  Tuberculosis (TB) is one of the top ten leading causes of death worldwide with millions of new TB cases reported every year. Understanding the genetic diversity of Mycobacterium tuberculosis (M. tuberculosis) is very ...
• Molecular epidemiology and antimicrobial resistance of Neisseria gonorrhoeae in men at risk in Gauteng South Africa 

  Maduna, Liteboho Daniel (University of Pretoria, 2020-02)

  Antimicrobial resistance (AMR) in Neisseria gonorrhoeae has emerged worldwide and treatment failures of ceftriaxone and azithromycin; the last remaining empirical first-line therapy for gonorrhoea, are reported. However, ...
• Genotypic and phenotypic diversity of Mycobacterium tuberculosis strains in patients with concomitant pulmonary and extra-pulmonary tuberculosis 

  Sibandze, Busizwe Busizwe (University of Pretoria, 2019)

  future, more robust or higher-resolution genomic typing tools, such as target Next Generation Sequencing (t-NGS) or metagenomic analysis are recommended to improve our understanding of the complexity of infections and for ...
• Genetic diversity of methicillin resistant Staphylococcus aureus strains in the Pretoria region in South Africa 

  Salawu, Adeola Mujidat (University of Pretoria, 2014)

  Staphylococcus aureus (S. aureus) is one of the leading causes of human diseases in hospital and community settings. Methicillin resistant Staphylococcus aureus (MRSA) has emerged as a significant problem worldwide, resisting ...

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