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Browsing Theses and Dissertations (Biochemistry) by Title
Now showing items 1-20 of 173
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(University of Pretoria, 2018)The aim of this study was to create a genomic resource for a typical plant genome from Illumina short reads, using Psidium guajava as a case study. Here we present a bioinformatics approach to produce a de novo plant genome ...
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(University of Pretoria, 2008-07-04)The serious threat of tuberculosis, especially XDR-TB, is a reality in Southern Africa particularly in individuals with HIV/AIDS. Therefore the importance of development of new or improved anti-TB treatment must now be ...
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(University of Pretoria, 2011-10-24)Genetic polymorphisms can be seen as the occurrence of more than one form of a DNA- or protein sequence at a single locus in a group of organisms, where these different forms occur more frequently than can be attributed ...
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(University of Pretoria, 2018-12-06)The growing occurrence of antimicrobial resistance (AMR) is a global cause for concern due to the decreased availability of effective antimicrobial drugs. Therefore, treating resistant infections can become costly or even ...
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(University of Pretoria, 2015)Lipopolysaccharides (LPS), when released from the outer membrane of Gram-negative bacteria, bind to macrophages, inducing production of pro-inflammatory cytokines and mediator molecules. In addition, associated overproduction ...
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(University of Pretoria, 2006-05-19)The need for new anti- TB drugs is increasingly rising because of the resistance of M. tuberculosis to existing drugs. The mycobacterial cell wall serves as an impermeable protective barrier for the bacilli from toxins and ...
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The Antiatherogenic Potential of Two triterpenes from Protorhus longifolia stem bark (Benrh.) Engl. (University of Pretoria, 2024-01)Atherocardiovascular diseases (ACVDs) are considered among the major causes of death in South Africa and worldwide. Hypercholesterolemia, which is the main major risk factor of atherosclerosis, increases the occurrence of ...
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(University of Pretoria, 2022-01)The disastrous effects of the foodborne pathogen Listeria monocytogenes have been observed overtime by global listeriosis outbreaks claiming many lives. The spread of this pathogen is being reported at high levels with ...
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(University of Pretoria, 2020-07)Candida albicans is a fungus found in the normal biota of humans, but in immuno-compromised individuals, C. albicans forms complex biofilms on the surface of medical prosthetics, skin, oral cavities, the urinary tract, ...
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(University of Pretoria, 2011-10-24)Ultra-high throughput DNA sequencing technologies have rapidly changed the face of genomic research projects. Technologies such as mRNA-Seq have the potential to rapidly profile the expressed gene-catalog of non-model ...
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(University of Pretoria, 2010-10-23)South Africa currently has the highest incidence of TB per 100 000 people in the world. In 2007 alone 112 000 people died of TB in South Africa, of which 94 000 were co-infected with HIV. Although TB treatments exist, poor ...
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(University of Pretoria, 2009-06-02)Accurate diagnosis of active tuberculosis is required to improve treatment, reduce transmission of the disease and control the emergence of drug resistance. A rapid and reliable test would make a considerable contribution ...
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(University of Pretoria, 2008-08-14)Malaria is the cause of over one million deaths per year, primarily in African children. The parasite responsible for the most virulent form of malaria, is Plasmodium falciparum. Protein structure plays a pivotal role in ...
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(University of Pretoria, 2014)Transcription is a complex biological phenomenon, whereby RNA is transcribed from single stranded template DNA by assembling targeted regulatory inputs at the promoter region. Transcription is regulated through many ...
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(University of Pretoria, 2014)With the emergence of drug resistant bacteria, the need for new antimicrobial agents is growing. Antimicrobial peptides (AMPs) are natural antibiotics which have a broad spectrum of activity and also due to a great diversity ...
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(University of Pretoria, 2013)Background: HIV/AIDS is one of the most devastating diseases in the world with approximately 36 million people living with the virus in 2012 and approximately 2.7 million new infections in that same year. Antiretroviral ...
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(University of Pretoria, 2012)Background: Decades after its discovery, the Human Immunodeficiency Virus-1 (HIV-1) remains a major threat to public health. Highly Active Antiretroviral Therapy (HAART) has been successful in the treatment of the virus; ...
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(University of Pretoria, 2006-03-01)In this study we investigated methods to increase tea quality by developing quality markers for the breeder, as well as methods to improve quality during the manufacturing process. The compounds investigated for identifying ...
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(University of Pretoria, 1992)Malaria parasites are responsible for an increase in the morbidity and mortality in several tropical regions in Southern Africa. In this thesis, research was undertaken on Plasmodium, which is responsible for more than 95% ...
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(University of Pretoria, 2011-06-27)Most studies on innate immunity in ticks have focused on the antimicrobial peptides from hemolymph, such as defensins and lysozyme, while less is known about bacterial recognition molecules, or antimicrobial mechanisms in ...
Now showing items 1-20 of 173