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- Browsing Theses and Dissertations (Biochemistry) by Issue Date
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Browsing Theses and Dissertations (Biochemistry) by Issue Date
Now showing items 1-20 of 173
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(University of Pretoria, 1992)Malaria parasites are responsible for an increase in the morbidity and mortality in several tropical regions in Southern Africa. In this thesis, research was undertaken on Plasmodium, which is responsible for more than 95% ...
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(University of Pretoria, 1998)Malaria is one of the most serious tropical infectious diseases affecting mankind. The prevention of the disease is hampered by the increasing resistance of the parasite to existing chemotherapy and -prophylaxis drugs. ...
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(University of Pretoria, 2001)In Silica analysis of available biological data is a powerful tool for not only the identification of new genes, but also to study evolutionary relationships and regulatory mechanisms. In this study, a number of bioinformatic ...
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(University of Pretoria, 2002)Invertebrates do not possess an adaptive immune system, but rely on several mechanisms similar to the innate immune system of mammals. The synthesis and release of a host of potent antimicrobial proteins is an important ...
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(University of Pretoria, 2002)Malaria remains one of the most serious tropical infectious diseases affecting mankind. The prevention of the disease is hampered by the increasing resistance of the parasite to existing chemotherapies. The need for novel ...
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(University of Pretoria, 2002)Please read the abstract in the section 00front of this document
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(University of Pretoria, 2005)Malaria kills nearly 1.5 million and affects more than 500 million people annually, mostly in sub-Saharan Africa. The malaria parasite has developed resistance against almost all of the known drugs used for treatment. This ...
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(University of Pretoria, 2005-05-19)Please read the abstract in the section 00front of this document
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(University of Pretoria, 2005-09-05)African horse sickness (AHS) is a lethal disease of horses. The aetiological agent is African horsesickness virus (AHSV) (genus Orbivirus; family: Reoviridae). Immunity to all nine serotypes is needed for full protection. ...
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(University of Pretoria, 2005-09-07)Mycobacterium tuberculosis (M. tuberculosis) , the etiological agent of tuberculosis, is an intracellular bacterium which persists within macrophages. Successful control of tuberculosis depends on T-cell-mediated immunity. ...
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(University of Pretoria, 2005-10-07)The pathogenicity of mycobacteria is directly related to their ability to survIve within macrophages, thereby circumventing host defense responses. This ability to resist degradation in macrophage phagosomes/lysosomes ...
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(University of Pretoria, 2005-11-22)Please read the abstract in the section 00front of this document
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(University of Pretoria, 2006-03-01)In this study we investigated methods to increase tea quality by developing quality markers for the breeder, as well as methods to improve quality during the manufacturing process. The compounds investigated for identifying ...
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Plasmodium falciparum dihydrofolate synthase (DHFS-FPGS) : gene synthesis and recombinant expression (University of Pretoria, 2006-05-19)Malaria causes nearly 3 million deaths annually. The parasite species responsible for the most lethal forms of malaria is P. falciparum (Miller et.al., 2002). Its destructive effect is most evident in the developing African ...
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(University of Pretoria, 2006-05-19)The need for new anti- TB drugs is increasingly rising because of the resistance of M. tuberculosis to existing drugs. The mycobacterial cell wall serves as an impermeable protective barrier for the bacilli from toxins and ...
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(University of Pretoria, 2006-05-19)Tuberculosis has re-emerged as a global health problem due to co-infection with HIV and the emergence of drug resistant strains of Mycobacterium tuberculosis. There is a need for a reliable and fast serodiagnostic assay ...
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(University of Pretoria, 2006-06-23)The saliva of hematophagous ectoparasites contains a cocktail of vasodilators, anticoagulants and immunosuppressors that maintain blood in a liquid state at the site of the lesion and evade the host's defense mechanisms ...
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(University of Pretoria, 2006-07-05)Tuberculosis has returned with vengeance mainly due to the resurgence of multi drug resistant strains incurred by non-compliance to the 6-9 months chemotherapy programme. Co-infection with HIV, which disorientates the ...
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(University of Pretoria, 2006-11-21)Commercial (high-grade) BaS04 selectively adsorbs two proteins from crude 0. savignyi salivary gland extracts. They co-purify during reversed-phase HPLC, but can be separated by hydrophobic-interaction chromatography. Both ...
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(University of Pretoria, 2007)The current costs of drug discovery are extremely high and need to be addressed if diseases such as AIDS and malaria are to be combated. The major reasons for the high costs are the use of expensive in vitro methods and ...
Now showing items 1-20 of 173