Please note that UPSpace will be unavailable from Friday, 2 May at 18:00 (South African Time) until Sunday, 4 May at 20:00 due to scheduled system upgrades. We apologise for any inconvenience this may cause and appreciate your understanding.
Browsing Research Articles (Nuclear Medicine) by Type "Article"
-
Ndlovu, Honest; Lawal, Ismaheel Opeyemi; Mdanda, Sipho; Kgatle, Mankgopo; Mokoala, K.M.G. (Kgomotso); Al-Ibraheem, Akram; Sathekge, Mike Machaba
(MDPI, 2024-06-11)
Including poly(ADP-ribose) polymerase (PARP) inhibitors in managing patients with
inoperable tumors has significantly improved outcomes. The PARP inhibitors hamper single-strand
deoxyribonucleic acid (DNA) repair by ...
-
Ismaila, Aisha; Lawal, Ismaheel Opeyemi; Popoola, Gbenga O.; Mathebula, Matsontso; Moagi, Ingrid; Mokoala, Kgomotso M.G.; Honest, Ndlovu; Moeketsi, Nontando; Nchabeleng, Maphoshane; Hikuam, Chris; Hatherill, Mark; Fourie, P.B. (Petrus Bernardus); Sathekge, Mike Machaba
(Springer, 2024-12)
BACKGROUND :
[18F]FDG-PET/CT is a sensitive non-invasive tool for assessing treatment response in patients with pulmonary tuberculosis. The data on the performance of [18F]FDG-PET/CT for response assessment among patients ...
-
Sathekge, Mike Machaba; Knoesen, Otto; Meckel, Marian; Modiselle, Moshe; Vorster, Mariza; Marx, Sebastian
(Springer, 2017-06)
Prostate-specific membrane antigen radioligand therapy
(PSMA-RLT) with 177Lu-PSMA holds great promise as a
safe treatment option in patients with metastasized
castration-resistant prostate cancer (mCRPC) with ...
-
Sathekge, Mike Machaba; Bruchertseifer, Frank; Knoesen, Otto; Reyneke, Florette; Lawal, Ismaheel Opeyemi; Lengana, Thabo; Davis, Cindy; Mahapane, Johncy; Corbett, Ceceila; Vorster, Mariza; Morgenstern, Alfred
(Springer, 2019-01)
BACKGROUND : A remarkable therapeutic efficacy has been demonstrated with 225Ac-prostate-specific membrane antigen (PSMA)-
617 in heavily pre-treated metastatic castration-resistant prostate cancer (mCRPC) patients.We ...
-
Sathekge, Mike Machaba; Bruchertseifer, Frank; Vorster, Mariza; Lawal, Ismaheel Opeyemi; Mokoala, Kgomotso M.G.; Reed, Janet D.; Maserumule, Letjie; Ndlovu, Honest; Hlongwa, Khanyi; Maes, Alex; Morgenstern, Alfred; Van de Wiele, Christophe
(Springer, 2023-06)
PURPOSE : 225Ac-PSMA-617 has demonstrated good anti-tumor effect as a treatment option for metastatic castration-resistant
prostate cancer (mCRPC) patients. No study has previously assessed treatment outcome and survival ...
-
Gouws, Christiaan A.; Naicker, Tricia; De la Torre, Beatriz G.; Albericio, Fernando; Duvenhage, Janie; Kruger, Hendrik G.; Marjanovic-Painter, Biljana; Mdanda, Sipho; Zeevaart, Jan Rijn; Ebenhan, Thomas; Govender, Thavendran
(Wiley, 2024-09)
Please read abstract in article.
-
Dendl, Katharina; Koerber, Stefan A.; Finck, Rebecca; Mokoala, Kgomotso M.G.; Staudinger, Fabian; Schillings, Lisa; Heger, Ulrike; Rohrich, Manuel; Kratochwil, Clemens; Sathekge, Mike Machaba; Jager, Dirk; Debus, Jurgen; Haberkorn, Uwe; Giesel, Frederik L.
(Springer, 2021-11)
PURPOSE : 68Ga-FAPI (fibroblast activation protein inhibitor) is a novel and highly promising radiotracer for PET/CT imaging. The aim of this retrospective analysis is to explore the potential of FAPI-PET/CT in gynecological ...
-
Bresser, Philppa Lynn; Reed, Janet D.; Sathekge, Mike Machaba; Vorster, Mariza
(Wiley Open Access, 2022-12)
Tuberculosis (TB) lesions in humans have been proven to be severely hypoxic with hypoxia leading to latency and dormancy of disease. Dormant TB lesions become less susceptible to standard TB treatment regimens with varying ...
-
Sathekge, Mike Machaba; Lengana, Thabo; Maes, Alex; Vorster, Mariza; Zeevaart, Jan Rijn; Lawal, Ismaheel Opeyemi; Ebenhan, Thomas; Van de Wiele, Christophe
(Springer, 2018-02)
PURPOSE : The incidence of prostate cancer is 60% higher and
the mortality rate is two- to three-times greater in black versus
white men. We report on differences in 68Ga-PSMA-11 PET/CT imaging findings in 77 black ...
-
Sathekge, Mike Machaba; Lengana, Thabo; Modiselle, Moshe; Vorster, Mariza; Zeevaart, Jan Rijn; Maes, Alex; Ebenhan, Thomas; Van de Wiele, Christophe
(Springer, 2017-04)
BACKGROUND : To report on imaging findings using 68Ga-PSMAHBED-
CC PET in a series of 19 breast carcinoma patients.
METHODS : 68Ga-PSMA-HBED-CC PET imaging results obtained
were compared to routinely performed staging ...
-
Lawal, Ismaheel Opeyemi; Popoola, Gbenga O.; Mahapane, Johncy; Kaufmann, Jens; Davis, Cindy; Ndlovu, Honest; Maserumule, Letjie C.; Mokoala, Kgomotso M.G.; Bouterfa, Hakim; Wester, Hans-Jurgen; Zeevaart, Jan Rijn; Sathekge, Mike Machaba
(MDPI, 2020-12)
People living with human immunodeficiency virus (PLHIV) have excess risk of atherosclerotic
cardiovascular disease (ASCVD). Arterial inflammation is the hallmark of atherogenesis and
its complications. In this study we ...
-
Kahts, Maryke; Guo, Hua; Kommidi, Harikrishna; Yang, Yanping; Sayman, Haluk Burcak; Summers, Beverley; Ting, Richard; Zeevaart, Jan Rijn; Sathekge, Mike Machaba; Aras, Omer
(SpringerOpen, 2023-11-06)
BACKGROUND : The non-invasive imaging of leukocyte trafficking to assess inflammatory
areas and monitor immunotherapy is currently generating great interest. There
is a need to develop more robust cell labelling and ...
-
Ramonaheng, Keamogetswe; Qebetu, Milani; Ndlovu, Honest; Swanepoel, Cecile; Smith, Liani; Mdanda, Sipho; Mdlophane, Amanda; Sathekge, Mike Machaba
(Frontiers Media, 2024-03)
Radiopharmaceutical therapy has been widely adopted owing primarily to the
development of novel radiopharmaceuticals. To fully utilize the potential of
these RPTs in the era of precision medicine, therapy must be optimized ...
-
Ankrah, Alfred O.; Creemers-Schild, Dina; De Keizer, Bart; Klein, Hans C.; Dierckx, Rudi A.J.O.; Kwee, Thomas C.; Span, Lambert F.R.; De Jong, Pim A.; Sathekge, Mike Machaba; Glaudemans, Andor W.J.M.
(MDPI, 2021-01-17)
Anatomy-based imaging methods are the usual imaging methods used in assessing invasive
fungal infections (IFIs). [18F]FDG PET/CT has also been used in the evaluation of IFIs. We assessed
the added value of [18F]FDG PET/CT ...
-
Docrat, F.; Mokoena, Taole; Karusseit, V.O.L. (Otto); Ankrah, Alfred O.
(Health and Medical Publishing Group, 2021-02)
BACKGROUND : Radioactive iodine (RAI) is widely used in the treatment of hyperthyroidism. Adjunctive antithyroid drugs (ATDs) are commonly prescribed to treat the hyperthyroid state before the RAI has taken effect. However, ...
-
Sathekge, Mike Machaba; Byttebier, Geert; De Spiegeleer, Bart; Saxberg, Bo; Ueckermann, Veronica; Belmans, Luc; Alexander, Myriam; Fedson, David
(MDPI, 2021-04-01)
The interaction between obesity, cardiometabolic disorders and COVID-19 represents a syndemic that requires both social intervention and a multipharmacological approach. The risks associated with diabetes, obesity and ...
-
Vorster, Mariza; Sathekge, Mike Machaba
(Elsevier, 2024-07)
Alpha theranostics offer an attractive alternative form of therapy, which has best been investigated and documented with 225Ac-PSMA in patients with prostate cancer. Advantages offered by targeted alpha therapy include ...
-
Gouws, Arno Christiaan; Kruger, Hendrik Gerhardus; Gheysens, Olivier; Zeevaart, Jan Rijn; Govender, Thavendran; Naicker, Tricia; Ebenhan, Thomas
(Wiley, 2022-11)
The excellent features of non-invasive molecular imaging, its progressive technology (real-time, whole-body
imaging and quantification), and global impact by a growing infrastructure for positron emission tomography ...
-
Ebenhan, Thomas; Gheysens, Olivier; Kruger, Hendrik G.; Zeevaart, Jan Rijn; Sathekge, Mike Machaba
(Hindawi Publishing, 2014-08)
Antimicrobial peptides (AMPs) are a heterogeneous class of compounds found in a variety of organisms including humans and,
so far, hundreds of these structures have been isolated and characterised. They can be described ...
-
Van de Wiele, Christophe; Ustmert, Sezgin; De Spiegeleer, Bart; De Jonghe, Pieter-Jan; Sathekge, Mike Machaba; Alex, Maes
(MDPI Publishing, 2021-03-09)
To date, a wide variety of potential PET-apoptosis imaging radiopharmaceuticals targeting
apoptosis-induced cell membrane asymmetry and acidification, as well as caspase 3 activation
(substrates and inhibitors) have been ...