• Evaluation of [68Ga]Ga-DOTA-AeK as a potential imaging tool for PET imaging of cell wall synthesis in bacterial infections 

  Koatale, Palesa Caroline; Welling, Mick M.; Mdanda, Sipho; Mdlophane, Amanda; Takyi-Williams, John; Durandt, Chrisna; Van den Bout, Iman; Cleeren, Frederik; Sathekge, Mike Machaba; Ebenhan, Thomas (MDPI, 2024-09)

  Please read abstract in article.
• [18F]F-poly(ADP-Ribose) polymerase inhibitor radiotracers for imaging PARP expression and their potential clinical applications in oncology 

  Ndlovu, Honest; Lawal, Ismaheel Opeyemi; Mdanda, Sipho; Kgatle, Mankgopo; Mokoala, K.M.G. (Kgomotso); Al-Ibraheem, Akram; Sathekge, Mike Machaba (MDPI, 2024-06-11)

  Including poly(ADP-ribose) polymerase (PARP) inhibitors in managing patients with inoperable tumors has significantly improved outcomes. The PARP inhibitors hamper single-strand deoxyribonucleic acid (DNA) repair by ...
• Time for action : actinium-225 PSMA-targeted alpha therapy for metastatic prostate cancer – a systematic review and meta-analysis 

  Ninatti, Gaia; Scilipoti, Pietro; Pini, Cristiano; Barletta, Francesco; Longoni, Mattia; Gelardi, Fabrizia; Sollini, Martina; Gandaglia, Giorgio; Sathekge, Mike Machaba; Montorsi, Francesco; Chiti, Arturo; Briganti, Alberto (Ivyspring International Publisher, 2025-02)

  RATIONALE : Metastatic prostate cancer in the castration-resistant (mCRPC) setting remains challenging to treat. Prostate-specific membrane antigen (PSMA)-targeted alpha therapy (TAT) is emerging as a promising option. We ...
• 68Ga radiolabeling of NODASA-functionalized phage display-derived peptides for prospective assessment as Tuberculosis-specific PET radiotracers 

  Gouws, Christiaan A.; Naicker, Tricia; De la Torre, Beatriz G.; Albericio, Fernando; Duvenhage, Janie; Kruger, Hendrik G.; Marjanovic-Painter, Biljana; Mdanda, Sipho; Zeevaart, Jan Rijn; Ebenhan, Thomas; Govender, Thavendran (Wiley, 2024-09)

  Please read abstract in article.
• Imaging molecular targets and metabolic pathways in breast cancer for improved clinical management: current practice and future perspectives 

  Ndlovu, Honest; Lawal, Ismaheel Opeyemi; Mokoala, K.M.G. (Kgomotso); Sathekge, Mike Machaba (MDPI, 2024-02)

  Breast cancer is the most frequently diagnosed cancer and leading cause of cancer-related deaths worldwide. Timely decision-making that enables implementation of the most appropriate therapy or therapies is essential for ...
• Real world experience with [99mTc]Tc-HYNIC-iPSMA SPECT prostate cancer detection : interim results from the global NOBLE registry 

  Tually, Pete; Quinto, Virginia G.; Omar, Yehia; Novruzov, Fuad; Yudistiro, Ryan; Sathekge, Mike Machaba; Currie, Geoffrey; Galette, Paul; Patel, Neel; Brown, Tracey; Bolland, Gabriel; Lo Bue, Rebecca; Cade, David (SpringerOpen, 2024-12)

  Please read abstract in article.
• Ionising radiation exposure-induced regulation of selected biomarkers and their impact in cancer and treatment 

  Mzizi, Yonwaba; Mbambara, Saidon; Moetlhoa, Boitumelo; Mahapane, Johncy; Mdanda, Sipho; Sathekge, Mike Machaba; Kgatle, Mankgopo (Frontiers Media, 2024-10)

  Ionising radiation (IR) is a form of energy that travels as electromagnetic waves or particles. While it is vital in medical and occupational health settings, IR can also damage DNA, leading to mutations, chromosomal ...
• EANM/SNMMI guideline/procedure standard for [18F]FDG hybrid PET use in infection and inflammation in adults v2.0 

  Abikhzer, Gad; Treglia, Giorgio; Pelletier‑Galarneau, Matthieu; Buscombe, John Richard; Chiti, Arturo; Dibble, Elizabeth H.; Glaudemans, Andor W.J.M.; Palestro, Christopher J.; Sathekge, Mike Machaba; Signore, Alberto; Jamar, Francois; Israel, Ora; Gheysens, Olivier (Springer, 2025-01)

  Please read abstract in article.
• Recently developed radiopharmaceuticals for bacterial infection imaging 

  Kahts, Maryke; Summers, Beverley; Gutta, Aadil; Pilloy, Wilfrid; Ebenhan, Thomas (SpringerOpen, 2024)

  Infection remains a major cause of morbidity and mortality, regardless of advances in antimicrobial therapy and improved knowledge of microorganisms. With the major global threat posed by antimicrobial resistance, fast and ...
• Chemokine receptor-4 targeted PET/CT imaging with 68Ga-Pentixafor in head and neck cancer—a comparison with 18F-FDG and CXCR4 immunohistochemistry 

  Hadebe, Bawinile; Harry, Lerwine; Gabela, Lerato; Masikane, Siphelele; Patel, Maryam; Zwane, Sizwe; Pillay, Venesen; Bipath, Presha; Cebekhulu, Nonhlanhla; Nyakale, Nozipho E.; Ramdass, Prathima; Msimang, Mpumelelo; Aldous, Colleen; Sathekge, Mike Machaba; Vorster, Mariza (MDPI, 2024-06)

  Please read abstract in article.
• Highlighting new research trends on Zirconium-89 radiopharmaceuticals beyond antibodies 

  Duvenhage, Janie; Kahts, Maryke; Summers, Beverley; Zeevaart, Jan Rijn; Ebenhan, Thomas (Elsevier, 2024-11)

  Please read abstract in the article.
• Prostate-specific membrane antigen-positron emission tomography-guided radiomics and machine learning in prostate carcinoma 

  Maes, Justine; Gesquière, Simon; Maes, Alex; Sathekge, Mike Machaba; Van de Wiele, Christophe (MDPI, 2024-10)

  Positron emission tomography (PET) using radiolabeled prostate-specific membrane antigen targeting PET-imaging agents has been increasingly used over the past decade for imaging and directing prostate carcinoma treatment. ...
• Radiotherapy and theranostics : a Lancet Oncology Commission 

  Abdel-Wahab, May; Giammarile, Francesco; Carrara, Mauro; Paez, Diana; Hricak, Hedvig; Ayati, Nayyereh; Li, Jing Jing; Mueller, Malina; Aggarwal, Ajay; Al-Ibraheem, Akram; Alkhatib, Sondos; Atun, Rifat; Bello, Abubakar; Berger, Daniel; Delgado Bolton, Roberto C.; Buatti, John M.; Burt, Graeme; Bjelac, Olivera Ciraj; Cordero-Mendez, Lisbeth; Dosanjh, Manjit; Eichler, Thomas; Fidarova, Elena; Gondhowiardjo, Soehartati; Gospodarowicz, Mary; Grover, Surbhi; Hande, Varsha; Harsdorf-Enderndorf, Ekaterina; Herrmann, Ken; Hofman, Michael S.; Holmberg, Ola; Jaffray, David; Knoll, Peter; Kunikowska, Jolanta; Lewis, Jason S.; Lievens, Yolande; Mikhail-Lette, Miriam; Ostwald, Dennis; Palta, Jatinder R.; Peristeris, Platon; Rosa, Arthur A.; Salem, Soha Ahmed; Dos Santos, Marcos A.; Sathekge, Mike Machaba; Shrivastava, Shyam Kishore; Titovich, Egor; Urbain, Jean-Luc; Vanderpuye, Verna; Wahl, Richard L.; Yu, Jennifer S.; Zaghloul, Mohamed Saad; Zhu, Hongcheng; Scott, Andrew M. (Elsevier, 2024-11)

  Following on from the 2015 Lancet Oncology Commission on expanding global access to radiotherapy, Radiotherapy and theranostics: a Lancet Oncology Commission was created to assess the access and availability of radiotherapy ...
• Activity quantification and dosimetry in radiopharmaceutical therapy with reference to 177Lutetium 

  Ramonaheng, Keamogetswe; Qebetu, Milani; Ndlovu, Honest; Swanepoel, Cecile; Smith, Liani; Mdanda, Sipho; Mdlophane, Amanda; Sathekge, Mike Machaba (Frontiers Media, 2024-03)

  Radiopharmaceutical therapy has been widely adopted owing primarily to the development of novel radiopharmaceuticals. To fully utilize the potential of these RPTs in the era of precision medicine, therapy must be optimized ...
• Editorial : bridging the gap to molecular imaging and theranostics 

  More, Stuart; Sathekge, Mike Machaba; Prasad, Vikas (Frontiers Media, 2024-04)

  No abstract available.
• First-in-human infection imaging with 89Zr-labelled leukocytes and comparison of scan quality with [99mTc]Tc-HMPAO-labelled leukocytes 

  Kahts, Maryke; Summers, Beverley; Ndlela, Akhona; Gutta, Aadil; Nemutaduni, Phumudzo; More, Andrew; Parsoo, Aman; Ebenhan, Thomas; Zeevaart, Jan Rijn; Aras, Omer; Sathekge, Mike Machaba (Frontiers Media, 2024-07)

  INTRODUCTION: Nuclear medicine infection imaging is routinely performed with the use of leukocytes radiolabelled with technetium-99m hexamethylpropyleneamine oxime ([99mTc]Tc-HMPAO) and single-photon emission computed ...
• Guiding principles on the education and practice of theranostics 

  Pascual, Thomas N.B.; Paez, Diana; Iagaru, Andrei; Gnanasegaran, Gopi; Lee, Sze Ting; Sathekge, Mike Machaba; Buatti, John M.; Giammarile, Francesco; Al-Ibraheem, Akram; Pardo, Manuela Arevalo; Baum, Richard P.; De Bari, Berardino; Ben-Haim, Simona; Blay, Jean-Yves; Brink, Anita; Estrada-Lobato, Enrique; Fanti, Stefano; Golubic, Anja Tea; Hatazawa, Jun; Israel, Ora; Kiess, Ana; Knoll, Peter; Louw, Lizette; Mariani, Giuliano; Mirzaei, Siroos; Orellana, Pilar; Prior, John O.; Urbain, Jean-Luc; Vichare, Shrikant; Vinjamuri, Sobhan; Virgolini, Irene; Scott, Andrew M. (Springer, 2024-07)

  PURPOSE : The recent development and approval of new diagnostic imaging and therapy approaches in the field of theranostics have revolutionised nuclear medicine practice. To ensure the provision of these new imaging and ...
• Can current preclinical strategies for radiopharmaceutical development meet the needs of targeted alpha therapy? 

  Kleynhans, Janke; Ebenhan, Thomas; Cleeren, Frederik; Sathekge, Mike Machaba (Springer, 2024-06)

  Preclinical studies are essential for effectively evaluating TAT radiopharmaceuticals. Given the current suboptimal supply chain of these radionuclides, animal studies must be refined to produce the most translatable TAT ...
• Advances in targeted alpha therapy of cancer 

  Sathekge, Mike Machaba; Morgenstern, Alfred (Springer, 2024-04)

  No abstract available.
• [18F]FDG PET and CT findings at therapy completion of pulmonary tuberculosis: comparison between HIV-positive and HIV-negative patients and impact on treatment response assessment 

  Ismaila, Aisha; Lawal, Ismaheel Opeyemi; Popoola, Gbenga O.; Mathebula, Matsontso; Moagi, Ingrid; Mokoala, Kgomotso M.G.; Honest, Ndlovu; Moeketsi, Nontando; Nchabeleng, Maphoshane; Hikuam, Chris; Hatherill, Mark; Fourie, P.B. (Petrus Bernardus); Sathekge, Mike Machaba (Springer, 2024-12)

  BACKGROUND : [18F]FDG-PET/CT is a sensitive non-invasive tool for assessing treatment response in patients with pulmonary tuberculosis. The data on the performance of [18F]FDG-PET/CT for response assessment among patients ...

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