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Browsing Physiology by Type "Article"
Now showing items 1-20 of 344
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(BioMed Central, 2015-04-22)INTRODUCTION : Research involving antimitotic compounds identified 2-methoxyestradiol (2ME2), as a promising anticancer endogenous metabolite. Owing to its low bioavailability, several in silico-designed 2ME2 analogues ...
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(Biomedical Research Press, 2013)2-Methoxyestradiol-bis-sulphamate (2-MeOE2bisMATE) is a bis-sulphamoylated analogue of a biological estradiol metabolite, 2-methoxyestradiol (2ME2) with potential as an anticancer drug. The aim of this in vitro study was ...
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(BioMed Central, 2012-08-20)BACKGROUND: Anticancer research resulted in the discovery of a promising antimitotic metabolite, 2-methoxyestradiol. 2-Methoxyestradiol-bis-sulphamate, a bis-sulphamoylated analogue exerts antiproliferative- and antimitotic ...
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(AOSIS Open Journals, 2013)2-MEBM induced apoptosis and autophagy in HeLa cells and also disrupted the cellular microtubule network. This contributes to the understanding of the in vitro mechanism of action of 2MEBM as a potential anticancer drug.
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(Suid Afrikaanse Akademie vir Wetenskap & Kuns, 2012)Future in vitro studies into the mechanism of this potentially anticancer drug are warranted.
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(BioMed Central, 2009-10)Originally described in 1953, today the so-called J-wave is the source of much controversy. As a marker of so-called "early repolarization", this variant has been regarded as a totally benign variant since the 1960's. ...
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(South African Society of Occupational Medicine, 2007)The WBGT index is the heat stress index of preference in the Occupational Health and Safety Act,No. 85 of 1993. The purpose of this investigation was to determine if equivalent WBGT values with low and high relative humidity ...
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(Media 24, 2015-04)Abundant evidence from randomised controlled trials has documented that antihypertensive drug treatment is of benefit in reducing cardiovascular (CV) events in people with hypertension.
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(MDPI Publishing, 2019-04-11)Osteoclasts are the sole bone resorbing cell in the body and their over activity is key in the development of osteoporosis. Osteoclastogenesis is mediated by receptor activator of nuclear factor B ligand (RANKL) signalling ...
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(The Royal Society, 2016)It is well known that a variety of inflammatory diseases are accompanied by hypercoagulability, and a number of more-or-less longer-term signalling pathways have been shown to be involved. In recent work, we have suggested ...
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(BMJ Publishing Group, 2022)OBJECTIVE : To determine the days until return to sport (RTS) after acute respiratory illness (ARill), frequency of time loss after ARill resulting in >1 day lost from training/competition, and symptom duration (days) of ...
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(BioMed Central, 2019-01)BACKGROUND: It remains unclear if ad libitum water drinking, as a hydration strategy, prevents exercise-associated hyponatremia (EAH) during prolonged exercise. The aim of this study was to determine the incidence of EAH ...
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(BioMed Central, 2013-04-11)The most important function of red blood cells (RBCs) is the carrying of oxygen, but they are also involved in inflammatory processes and during coagulation. RBCs are extremely deformable and elastic, as they are exposed ...
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(Pharmacotherapy Group, 2020-05)PURPOSE : To investigate the potential prophylactic effect of S-allyl cysteine (SAC), found in garlic (Allium sativum), against the development of apro-inflammatory status induced by diet in neonatal rats later on in ...
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(AOSIS, 2018-09-11)Pellagra is characterised by dermatological, gastrointestinal and neuropsychiatric manifestations. Millions contracted the disease and hundreds of thousands died between the time it was first recorded until pellagra was ...
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Angiotensin II type 1 receptor antagonists and their combinations in the treatment of hypertension (South African Academy of Family Practice/Primary Care, 2012)No abstract available.
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(South African Academy of Family Practice/Primary Care, 2011-01)No abstract available.
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(SpringerOpen, 2015-12)Cancer is a complex disease since it is adaptive in such a way that it can promote proliferation and invasion by means of an overactive cell cycle and in turn cellular division which is targeted by antimitotic drugs that ...
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(Public Library of Science, 2015-04-13)An unbalanced diet can have adverse effects on health. Long chain polyunsaturated fatty acids (LCPUFAs) have been the focus of research owing to their necessity of inclusion in a healthy diet. However, the effects of ...
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(Elsevier, 2020-01)Bone remodelling in a healthy body is in constant balance, maintaining an adaptive and robust skeletal system. In osteoporosis this balance is disrupted with the rates of osteoclastic bone resorption exceeding osteoblastic bone ...
Now showing items 1-20 of 344