Phenotypic characterisation of bone marrow-derived haematopoietic stem/progenitor cells from HIV-infected individuals

Abstract

Human immunodeficiency virus (HIV-1) infection remains a significant global public health concern, particularly in sub-Saharan Africa where the majority of HIV-1 infections are concentrated. People living with HIV (PLWH) often present with haematological abnormalities including alterations of the bone marrow (BM; dysplasia and cellularity changes) and most commonly cytopenias (anaemia, thrombocytopenia and neutropenia). From these clinical observations it is clear that HIV not only impacts the immune system but also the broader haematopoietic system. The underlying cause of HIV-mediated changes in the haematological system remains complex and multifactorial.