Please note that UPSpace will be unavailable from Friday, 2 May at 18:00 (South African Time) until Sunday, 4 May at 20:00 due to scheduled system upgrades. We apologise for any inconvenience this may cause and appreciate your understanding.
dc.contributor.author | Demetriou, Demetra Danielle![]() |
|
dc.contributor.author | Lockhat, Zarina I.![]() |
|
dc.contributor.author | Brzozowski, Luke![]() |
|
dc.contributor.author | Saini, Kamal S.![]() |
|
dc.contributor.author | Dlamini, Zodwa![]() |
|
dc.contributor.author | Hull, Rodney![]() |
|
dc.date.accessioned | 2024-11-13T05:47:33Z | |
dc.date.available | 2024-11-13T05:47:33Z | |
dc.date.issued | 2024-03 | |
dc.description | This article belongs to the Special Issue titled 'Imaging in Breast Cancer Diagnosis and Treatment'. | en_US |
dc.description.abstract | Despite significant progress in the prevention, screening, diagnosis, prognosis, and therapy of breast cancer (BC), it remains a highly prevalent and life-threatening disease affecting millions worldwide. Molecular subtyping of BC is crucial for predictive and prognostic purposes due to the diverse clinical behaviors observed across various types. The molecular heterogeneity of BC poses uncertainties in its impact on diagnosis, prognosis, and treatment. Numerous studies have highlighted genetic and environmental differences between patients from different geographic regions, emphasizing the need for localized research. International studies have revealed that patients with African heritage are often diagnosed at a more advanced stage and exhibit poorer responses to treatment and lower survival rates. Despite these global findings, there is a dearth of in-depth studies focusing on communities in the African region. Early diagnosis and timely treatment are paramount to improving survival rates. In this context, radiogenomics emerges as a promising field within precision medicine. By associating genetic patterns with image attributes or features, radiogenomics has the potential to significantly improve early detection, prognosis, and diagnosis. It can provide valuable insights into potential treatment options and predict the likelihood of survival, progression, and relapse. Radiogenomics allows for visual features and genetic marker linkage that promises to eliminate the need for biopsy and sequencing. The application of radiogenomics not only contributes to advancing precision oncology and individualized patient treatment but also streamlines clinical workflows. This review aims to delve into the theoretical underpinnings of radiogenomics and explore its practical applications in the diagnosis, management, and treatment of BC and to put radiogenomics on a path towards fully integrated diagnostics. | en_US |
dc.description.department | Medical Oncology | en_US |
dc.description.department | Radiology | en_US |
dc.description.sdg | SDG-03:Good heatlh and well-being | en_US |
dc.description.sponsorship | The South African Medical Research Council (SAMRC) and the National Research Foundation (NRF). | en_US |
dc.description.uri | https://www.mdpi.com/journal/cancers | en_US |
dc.identifier.citation | Demetriou, D.; Lockhat, Z.; Brzozowski, L.; Saini, K.S.; Dlamini, Z.; Hull, R. The Convergence of Radiology and Genomics: Advancing Breast Cancer Diagnosis with Radiogenomics. Cancers 2024, 16, 1076. https://doi.org/10.3390/cancers16051076. | en_US |
dc.identifier.issn | 2072-6694 (online) | |
dc.identifier.other | 10.3390/cancers16051076 | |
dc.identifier.uri | http://hdl.handle.net/2263/99033 | |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.rights | © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | en_US |
dc.subject | Breast cancer | en_US |
dc.subject | Prognosis | en_US |
dc.subject | Molecular heterogeneity | en_US |
dc.subject | Radiogenomics | en_US |
dc.subject | Precision medicine | en_US |
dc.subject | Early diagnosis | en_US |
dc.subject | Treatment options | en_US |
dc.subject | Clinical behaviors | en_US |
dc.subject | Localized research | en_US |
dc.subject | Global disparities | en_US |
dc.subject | SDG-03: Good health and well-being | en_US |
dc.title | The convergence of radiology and genomics : advancing breast cancer diagnosis with radiogenomics | en_US |
dc.type | Article | en_US |