Single-cell transcriptomics identifies aberrant glomerular angiogenic signalling in the early stages of WT1 kidney disease
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| dc.contributor.author | Chandler, Jennifer C.
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| dc.contributor.author | Jafree, Daniyal J.
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| dc.contributor.author | Malik, Saif
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| dc.contributor.author | Pomeranz, Gideon
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| dc.contributor.author | Ball, Mary
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| dc.contributor.author | Kolatsi-Joannou, Maria
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| dc.contributor.author | Piapi, Alice
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| dc.contributor.author | Mason, William J.
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| dc.contributor.author | Benest, Andrew V.
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| dc.contributor.author | Bates, David O.
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| dc.contributor.author | Letunovska, Aleksandra
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| dc.contributor.author | Al-Saadi, Reem
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| dc.contributor.author | Rabant, Marion
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| dc.contributor.author | Boyer, Olivia
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| dc.contributor.author | Pritchard-Jones, Kathy
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| dc.contributor.author | Winyard, Paul J.
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| dc.contributor.author | Mason, Andrew S.
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| dc.contributor.author | Woolf, Adrian S.
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| dc.contributor.author | Waters, Aoife M.
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| dc.contributor.author | Long, David A.
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| dc.date.accessioned | 2024-10-31T07:28:20Z | |
| dc.date.available | 2024-10-31T07:28:20Z | |
| dc.date.issued | 2024-10 | |
| dc.description | DATA AVAILABILITY STATEMENT : Primary sequencing data reported in this paper are available on NCBI Sequence Read Archive (SRA PRJNA928337). Processed data for scRNA-seq experiments are available on Zenodo at DOI: 10.5281/zenodo.7565867. The codes generated during this study are available at Github repository https://github.com/daniyal-jafree1995/collaborations. All other unique reagents used in this study are available from the corresponding author on reasonable request. | en_US |
| dc.description | SUPPLEMENTARY MATERIALS AND METHODS : FIGURE S1. Supporting data for single-cell RNA seq analyses. FIGURE S2. Characterisation of primary cell lines. FIGURE S3. Isolation of podocytes from scRNA-seq data from additional murine models of glomerular disease for cross-disease comparison. FIGURE S4. Dysregulated genes shown by individual sample for each human glomerular pathology (source Nephroseq). TABLE S1. Differentially expressed genes in glomerular cells in Wt1R394W/+ mice. TABLE S2. Podocyte differentially expressed genes that are conserved across murine glomerular scRNA-seq datasets or unique to Wt1R394W/+. TABLE S3. Podocyte differentially expressed genes classified in ‘GO:0002376 – immune system process’ across murine glomerular scRNA-seq datasets. | en_US |
| dc.description.abstract | Please read abstract in the article. | en_US |
| dc.description.department | Medical Oncology | en_US |
| dc.description.librarian | hj2024 | en_US |
| dc.description.sdg | SDG-03:Good heatlh and well-being | en_US |
| dc.description.sponsorship | LifeArc/Great Ormond Street Children's Charity; Medical Research Centre; Kidney Research UK; British Heart Foundation; Diabetes UK; Wellcome Trust. | en_US |
| dc.description.uri | https://onlinelibrary.wiley.com/journal/10969896 | en_US |
| dc.identifier.citation | Chandler J.C., Jafree D.J., Malik S. et al. 2024, 'Single-cell transcriptomics identifies aberrant glomerular angiogenic signalling in the early stages of WT1 kidney disease', Journal of Pathology, vol. 264, no. 2, pp. 212-227, doi : 10.1002/path.6339. | en_US |
| dc.identifier.issn | 0022-3417 (print) | |
| dc.identifier.issn | 1096-9896 (online) | |
| dc.identifier.other | 10.1002/path.6339 | |
| dc.identifier.uri | http://hdl.handle.net/2263/98857 | |
| dc.language.iso | en | en_US |
| dc.publisher | Wiley | en_US |
| dc.rights | © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. This is an open access article under the terms of the Creative Commons Attribution License. | en_US |
| dc.subject | Vascular endothelial growth factor-A | en_US |
| dc.subject | WT1 glomerulopathy | en_US |
| dc.subject | Wilms tumour 1 (WT1) | en_US |
| dc.subject | Single-cell transcriptomics | en_US |
| dc.subject | Podocyte | en_US |
| dc.subject | Neuropilin-1 | en_US |
| dc.subject | Glomerular endothelium | en_US |
| dc.subject | Childhood glomerular disease | en_US |
| dc.subject | Adrenomedullin | en_US |
| dc.subject | SDG-03: Good health and well-being | en_US |
| dc.title | Single-cell transcriptomics identifies aberrant glomerular angiogenic signalling in the early stages of WT1 kidney disease | en_US |
| dc.type | Article | en_US |
