Novel 3-trifluoromethyl-1,2,4-oxadiazole analogues of astemizole with multi-stage antiplasmodium activity and in vivo efficacy in a Plasmodium berghei mouse malaria infection model
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| dc.contributor.author | Mambwe, Dickson
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| dc.contributor.author | Korkor, Constance M.
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| dc.contributor.author | Mabhula, Amanda
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| dc.contributor.author | Ngqumba, Zama
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| dc.contributor.author | Cloete, Cleavon
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| dc.contributor.author | Kumar, Malkeet
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| dc.contributor.author | Barros, Paula Ladeia
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| dc.contributor.author | Leshabane, Meta Kgaogelo
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| dc.contributor.author | Coertzen, Dina
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| dc.contributor.author | Taylor, Dale
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| dc.contributor.author | Gibhard, Liezl
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| dc.contributor.author | Njoroge, Mathew
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| dc.contributor.author | Lawrence, Nina
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| dc.contributor.author | Reader, Janette
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| dc.contributor.author | Moreira, Diogo Rodrigo
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| dc.contributor.author | Birkholtz, Lyn-Marie
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| dc.contributor.author | Wittlin, Sergio
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| dc.contributor.author | Egan, Timothy J.
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| dc.contributor.author | Chibale, Kelly
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| dc.date.accessioned | 2023-02-24T08:08:34Z | |
| dc.date.issued | 2022-12 | |
| dc.description.abstract | Please read abstract in the article. | en_US |
| dc.description.department | Biochemistry | en_US |
| dc.description.department | Genetics | en_US |
| dc.description.department | Microbiology and Plant Pathology | en_US |
| dc.description.department | UP Centre for Sustainable Malaria Control (UP CSMC) | en_US |
| dc.description.embargo | 2023-12-12 | |
| dc.description.librarian | hj2023 | en_US |
| dc.description.uri | http://pubs.acs.org/loi/jmcmar | en_US |
| dc.identifier.citation | Mambwe, D., Korkor, C.M., Mabhula, A. et al. 2022, 'Novel 3-trifluoromethyl-1,2,4-oxadiazole analogues of astemizole with multi-stage antiplasmodium activity and in vivo efficacy in a Plasmodium berghei mouse malaria infection model', Journal of Medicinal Chemistry, vol. 65, no. 24, pp. 16695–16715, doi : 10.1021/acs.jmedchem.2c01516. | en_US |
| dc.identifier.issn | 0022-2623 (print) | |
| dc.identifier.issn | 1520-4804 (online) | |
| dc.identifier.other | 10.1021/acs.jmedchem.2c01516 | |
| dc.identifier.uri | https://repository.up.ac.za/handle/2263/89809 | |
| dc.language.iso | en | en_US |
| dc.publisher | American Chemical Society | en_US |
| dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Medicinal Chemistry, © 2022 American Chemical Society after peer review and technical editing by the publisher. [12 months embargo] | en_US |
| dc.subject | Astemizole | en_US |
| dc.subject | Repositioning | en_US |
| dc.subject | Plasmodium falciparum | en_US |
| dc.subject | Plasmodium berghei | en_US |
| dc.subject | Human ether-á-go-go-related gene (hERG) | en_US |
| dc.subject | Live-cell microscopy | en_US |
| dc.title | Novel 3-trifluoromethyl-1,2,4-oxadiazole analogues of astemizole with multi-stage antiplasmodium activity and in vivo efficacy in a Plasmodium berghei mouse malaria infection model | en_US |
| dc.type | Postprint Article | en_US |
