First report of blaIMP-14 on a plasmid harboring multiple drug resistance genes in Escherichia coli sequence type 131

Stoesser, Nicole; Sheppard, Anna E.; Peirano, Gisele; Sebra, Robert; Lynch, Tarah; Anson, Luke; Kasarskis, Andrew; Motyl, Mary R.; Crook, Derrick W.; Pitout, Johann D.D.

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First report of blaIMP-14 on a plasmid harboring multiple drug resistance genes in Escherichia coli sequence type 131

Stoesser, Nicole; Sheppard, Anna E.; Peirano, Gisele; Sebra, Robert; Lynch, Tarah; Anson, Luke; Kasarskis, Andrew; Motyl, Mary R.; Crook, Derrick W.; Pitout, Johann D.D.

URI: http://hdl.handle.net/2263/53392

Date: 2016-08

Abstract:

The blaIMP-14 carbapenem resistance gene has largely previously been observed in Pseudomonas aeruginosa and Acinetobacter spp. As part of global surveillance and sequencing of carbapenem-resistant E. coli, we identified an ST131 strain harboring blaIMP-14 within a class 1 integron, itself nested within a ~54kb multi-drug resistance region on an epidemic IncA/C2 plasmid. The emergence of blaIMP-14 in this context in the ST131 lineage is of potential clinical concern.

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