Characterization and phylogenetic analysis of South African HIV-1 subtype C accessory genes

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Characterization and phylogenetic analysis of South African HIV-1 subtype C accessory genes

Scriba, Thomas Jens; Treurnicht, Florette K.; Zeier, Michelle D.; Engelbrecht, Susan; Janse van Rensburg, Estrelita
URI: http://hdl.handle.net/2263/3218
Date: 2001-05

Abstract:

To acquire new knowledge about the genetic diversity and potential impact on vaccine strategies of HIV-1 subtype C in South Africa, we have characterized the vif, vpr, and vpu genes of 15 isolates. Phylogenetic analysis of the genomic fragment encompassing these genes revealed subtype C subclusters, suggesting close relatedness with subtype C strains from other geographic locations and excluded isolation of South African strains. The putative T155 phosphorylation site in the C terminal of Vif was absent in all subtype C sequences. Variation in the predicted amino acid sequences of the three genes further showed strong correlation with other subtype C sequences.

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