Detection of EBV DNA in oral squamous cell carcinomas in a black African population sample

Janse van Rensburg, Estrelita; Engelbrecht, Susan; Van Heerden, Willem Francois Petrus; Raubenheimer, E.J.; Schoub, Barry D.

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dc.contributor.author	Janse van Rensburg, Estrelita
dc.contributor.author	Engelbrecht, Susan
dc.contributor.author	Van Heerden, Willem Francois Petrus
dc.contributor.author	Raubenheimer, E.J.
dc.contributor.author	Schoub, Barry D.
dc.date.accessioned	2007-07-25T08:25:35Z
dc.date.available	2007-07-25T08:25:35Z
dc.date.issued	1995-05
dc.description	This article was co-written by Prof Janse van Rensburg before she joined the University of Pretoria.	en
dc.description.abstract	The purpose of this study was to determine the presence of Epstein-Barr virus (EBV) DNA in oral squamous cell carcinoma (OSCC) patients from a black African population. Formalin fixed paraffin embedded blocks of OSCC of two randomly selected groups were investigated. Group 1 consisting of 57 blocks containing OSCC with a fragment of normal appearing adjacent/overlying epithelium. Group 2 consisted of 48 blocks containing only OSCC tissue without any normal appearing epithelium. The control group consisted of 38 non-malignant, non-viral associated lesions. A standard polymerase chain reaction (PCR) was used to amplify the Bam HI W-fragment using a nested primer set. EBV DNA was demonstrated in 14/57 (25%) blocks from Group 1, in 13/48 (27%) blocks from Group 2 and in 16/38 (42%) blocks from the control group. No evidence for a direct role of EBV in the process of malignant transformation of intraoral epithelial cells was found in this study.	en
dc.format.extent	8503 bytes
dc.format.mimetype	application/pdf
dc.identifier.citation	Janse van Rensburg, E, Engelbrecht, S, Van Heerden, WFP, Raubenheimer, E & Schoub BD 1995, 'Detection of EBV DNA in oral squamous cell carcinomas in a black African population sample', In Vivo, vol. 9, no. 3, pp. 199-202. [http://www.iiar-anticancer.org/invivo/invivo_index.htm]	en
dc.identifier.issn	0258-851X
dc.identifier.uri	http://hdl.handle.net/2263/3136
dc.language.iso	en	en
dc.publisher	International Institute of Anticancer Research	en
dc.rights	International Institute of Anticancer Research The publisher prohibits open access to the full text of this article.	en
dc.subject.lcsh	Squamous cell carcinoma -- Blacks -- Africa
dc.subject.lcsh	Epstein-Barr virus -- Research -- Blacks -- Africa
dc.title	Detection of EBV DNA in oral squamous cell carcinomas in a black African population sample	en
dc.type	Article	en