Pharmacology: Recent submissions

Now showing items 1-20 of 419

Evaluating blood-brain barrier permeability, cytotoxicity, and activity of potential acetylcholinesterase inhibitors : in vitro and in silico study

Maboko, Lerato Mamabote; Theron, A.; Panayides, J._L.; Cordier, Werner; Fisher, D.; Steenkamp, Vanessa (Wiley, 2024-12)

Acetylcholinesterase inhibitors (AChEIs) remain the first-line treatment for Alzheimer's disease. However, these drugs are largely symptomatic and often associated with adverse effects. This study aimed to evaluate novel ...
Pilot study to evaluate patients' understanding of key terms and aspects of antimicrobial use in a rural province in South Africa : findings and implications

Sono, Tiyani Milta; Mboweni, Veronica; Jelic, Ana Golic; Campbell, Stephen M.; Markovic-Pekovic, Vanda; Ramdas, Nishana; Schellack, Natalie; Kumar, Santosh; Godman, Brian; Meyer, Johanna C. (Wolters Kluwer Medknow Publications, 2025-01)

INTRODUCTION : Antimicrobial resistance (AMR) is a global concern, necessitating the understanding of utilisation patterns and their rationale. Pilot studies have been conducted in a rural province in South Africa to ...
The role of patients with addressing inappropriate dispensing of antibiotics without a prescription especially in developing countries

Sono, Tiyani Milta; Schellack, Natalie; Godman, Brian (Wolters Kluwer Medknow Publications, 2025-01)

Antimicrobial resistance (AMR) is a growing global concern, significantly impacting on morbidity, mortality and healthcare costs, especially in low- and middle-income countries (LMICs).
Antimicrobial therapeutic drug monitoring in critically ill adult patients : an international perspective on access, utilisation, and barriers

Williams, Paul G.; Cotta, Menino Osbert; Tabah, Alexis; Sandaradura, Indy; Kanji, Salmaan; Scheetz, Marc H.; Imani, Sahand; Elhadi, Muhammed; Pardos, Sònia L.; Schellack, Natalie; Sanches, Cristina; Timsit, Jean‑Francois; Xie, Jiao; Farkas, Andras; Wilks, Kathryn; Roberts, Jason A. (Elsevier, 2024-08)

BACKGROUND: Therapeutic drug monitoring (TDM) is an effective method for individualising antimicrobial therapy in critically ill patients. The 2021 ADMIN-intensive care unit survey studied a wide range of intensive care ...
Sodium, potassium-adenosine triphosphatase as a potential target of the anti-tuberculosis agents, clofazimine and bedaquiline

Mmakola, Khomotso Madimetsa Shelboy; Balmith, Marissa [; Steel, Helen C.; Said, Mohamed; Potjo, Moliehi; Van der Mescht, Mieke Adri; Hlatshwayo, Nomsa; Meyer, Pieter Willem Adriaan; Tintinger, Gregory Ronald; Anderson, Ronald; Cholo, Moloko C. (MDPI, 2024-12-04)

Multidrug-resistant tuberculosis (MDR-TB) patients are treated with a standardised, short World Health Organization (WHO) regimen which includes clofazimine (CFZ) and bedaquiline (BDQ) antibiotics. These two antibiotics ...
South African dietitians' knowledge and perceptions of food-drug interactions and factors affecting it

Megaw, Christie; Olivier, Natascha; Cordier, Werner (Wiley, 2025-02)

BACKGROUND : Dietitians ensure that patients receive tailored medical nutrition therapy to integrate with pharmacotherapy safely. Dietitians require a pharmacological understanding to prevent detrimental food-drug interactions ...
Glioblastoma cells alter brain endothelial cell homeostasis and tight junction protein expression in vitro

Mokoena, Xolisile; Mabeta, Peaceful Lucy; Cordier, Werner; Flepisi, Brian Thabile (Springer, 2025-01)

BACKGROUND : Glioblastoma (GBM) is an aggressive therapy-resistant brain tumour that may impacts the integrity of the blood–brain barrier (BBB). The BBB is a protective barrier of the central nervous system formed mainly ...
An ethnobotanical survey and pharmacological and toxicity review of medicinal plants used in the management of obesity in the North Central Zone of Nigeria

Anyanwu, Gabriel O.; Anzaku, Dorathy; Bulus, Yanga J.; Girgi, Jemimah N.; Donwell, Chinda C.; Ihuma, Jerome O.; Onyeneke, Eusebius C.; Bermano, Giovanna; Steenkamp, Vanessa (Wiley, 2025-02)

INTRODUCTION : Obesity is increasing worldwide. Due to the unavailability of affordable obesity drugs in most parts of Nigeria, many overweight and obese people rely on medicinal plants to manage obesity. Thus, the aim of ...
Transitioning to quick response codes for patient information leaflet delivery

Singh, Githa; Brand, S.J. (Sarel); Steenkamp, Vanessa (Elsevier, 2025-03)

BACKGROUND : The inclusion of a patient information leaflet (PIL) in medicine packaging is a legal requirement in most countries. OBJECTIVE : To evaluate the feasibility of using quick response (QR) codes for electronic ...
Knowledge, attitudes, motivations and expectations regarding antimicrobial use among community members seeking care at the primary healthcare level : a scoping review protocol

Ramdas, Nishana; Meyer, Johanna C.; Schellack, Natalie; Godman, Brian; Turawa, Eunice Bolanle; Campbell, Stephen M. (BMJ Publishing Group, 2025-02)

INTRODUCTION : Inappropriate antibiotic use in (primary healthcare, PHC) settings fuels antimicrobial resistance (AMR), threatens patient safety and burdens healthcare systems. Patients’ knowledge, attitudes, motivations ...
Knowledge, attitudes, motivations, expectations, and systemic factors regarding antimicrobial use amongst community members seeking care at the primary healthcare level: a scoping review

Ramdas, Nishana; Meyer, Johanna C.; Schellack, Natalie; Godman, Brian; Turawa, Eunice; Campbell, Stephen M. (MDPI, 2025-01)

BACKGROUND/OBJECTIVES : Antimicrobial resistance (AMR) is a major global health challenge, particularly in low- and middle-income countries (LMICs). Understanding the knowledge, attitudes, motivations, and expectations of ...
The malaria burden : a South African perspective

Balmith, Marissa; Basson, Charlize; Brand, Sarel Jacobus (Wiley, 2024-02-23)

Malaria is a deadly disease caused by protozoan pathogens of the Plasmodium parasite. Transmission to humans occurs through the bite of an infected female Anopheles mosquito. According to the World Health Organization ...
Mapping evidence on the regulations affecting accessibility, availability and management of snake antivenom globally : a scoping review protocol

Majeed, Ramsha; Bester, Janette; Kgarosi, Kabelo; Strydom, Morné (BMJ Publishing Group, 2024-12)

INTRODUCTION: Snakebite envenomation has been declared a neglected tropical disease by the WHO since 2017. The disease is endemic in affected areas due to the lack of availability and access to antivenom, despite it being ...
Use of osteogenic bone matrix in patients with traumatic long bone defects : an open label, single center study

Murdoch, Marshall; Wittstock, Craig; Psaras, George; Widgerow, Alan; Lukhele, Mkhululi; Ramokgopa, Mmampapatla Thomas; Snyman, Jacques; Hutchings, Jane; Marcos, Elizabeth; Grisillo Biscardi, Anna; Cromarty, A.D.; Zheng, Xu; Duneas, Nicolaas; Govender, Shunmugam (Elsevier, 2025-02)

BACKGROUND : Osteogenic Bone Matrix (Altis™ OBM) is a tissue-engineered, porcine-derived demineralized bone matrix prepared using a humanization processing technology that confers biocompatibility and improved osteoinductivity. ...
Evaluation of Taraxacum officinale phytoconstituents as potential JNK1 inhibitors : perspectives from ADMET, molecular docking, molecular dynamics, and density functional theory

Sosibo, Sphelele C.; Kruger, Hendrik G.; Nxumalo, Wonder Praise-God; Zondi, Zimbili (Elsevier, 2024-12)

The impact of activated c-Jun N-terminal kinase isoform JNK1 chemical pathways in insulin biosynthesis poses a potential health risk of glucose intolerance. Blocking the activity of JNK1 is a promising route for the design ...
Insomnia : what is currently available

Marais, Andre; Osuch, Elzbieta (Medpharm Publications, 2023)

Insomnia is an important public health burden and is the most ubiquitous sleep disorder in the general population, requiring accurate diagnosis and effective treatment. Sleep hygiene and cognitive behavioural therapy form ...
Prevalence of chronic kidney disease and associated risk factors among people living with HIV in a rural population of Limpopo province, South Africa

Choshi, Joel; Flepisi, Brian Thabile; Mabhida, Sihle E.; Sekgala, Machoene Derrick; Mokoena, Haskly; Nkambule, Bongani B.; Ndwandwe, Duduzile; Mchiza, Zandile J.; Nqebelele, Unati; Kengne, Andre P.; Dludla, Phiwayinkosi V.; Hanser, Sidney (Frontiers Media, 2024-07)

BACKGROUND: Limited evidence informs on the prevalence of chronic kidney disease (CKD) in people living with HIV (PLWH) in South Africa. Thus, this study aimed to determine the prevalence of CKD and its associated risk ...
An evaluation of knowledge and perception of pharmacology in undergraduate oral hygiene students and recent graduates at a single higher institution in Pretoria

Balmith, Marissa; Cordier, Werner; Bhayat, Ahmed; Basson, Charlize; Morule, Mpho; Schellack, Natalie (Wiley, 2024-11)

INTRODUCTION : Pharmacology is an increasingly important area of study for oral hygienists, as it provides the scientific basis for safe and effective oral healthcare. However, a lack of fundamental understanding of the ...
Evolution of drug development and regulatory affairs: the demonstrated power of artificial intelligence

Nene, Linda; Flepisi, Brian Thabile; Brand, Sarel Jacobus; Basson, Charlize; Balmith, Marissa (Elsevier, 2024-08)

PURPOSE : Artificial intelligence (AI) refers to technology capable of mimicking human cognitive functions and has important applications across all sectors and industries, including drug development. This has considerable ...
Off-label and unlicenced medicine use among hospitalised children in South Africa : practice and policy implications

Mathevula, Hlayiseka; Schellack, Natalie; Orubu, Samuel; Godman, Brian; Matlala, Moliehi (MDPI, 2023-12)

BACKGROUND : Information regarding off-label and unlicensed medicine use among South African children is limited. This is a concern as the prescribing of off-label and unlicensed medicines can lead to issues of effectiveness ...

Now showing items 1-20 of 419

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