Reply to Datta, “Is static or cidal antibiotic falsifiable?”

Abstract

We would like to thank Dr. Datta for his interest in our article. Dr. Datta wishes to defend the static vs. cidal antibiotic model against “absolutist framing.” He invokes “mono-parametric” assays like “MBC/MIC ratios or…reactive oxygen species generation” to suggest that in vitro static vs. cidal phenomenology may be phenotypically real.

Description

Keywords

Static vs. cidal antibiotic model, Absolutist framing, Mono-parametric, In vitro, Reply

Sustainable Development Goals

SDG-03: Good health and well-being

Citation

Spellberg, B., Wald-Dickler, N., Holtom, P. et al. 2025, 'Reply to Datta, “Is static or cidal antibiotic falsifiable?”', Antimicrobial Agents and Chemotherapy, vol. 69, no. 11, pp. 1-3. https://doi.org/10.1128/aac.01361-25.