Persistently elevated expression of systemic, soluble co-inhibitory immune checkpoint molecules in people living with HIV before and one year after antiretroviral therapy

dc.contributor.authorLabuschagne Naidoo, Robyn-Brooke
dc.contributor.authorSteel, Helen C.
dc.contributor.authorTheron, Annette J.
dc.contributor.authorAnderson, Ronald
dc.contributor.authorTintinger, Gregory Ronald
dc.contributor.authorRossouw, Theresa M.
dc.contributor.emailtheresa.rossouw@up.ac.zaen_US
dc.date.accessioned2025-04-08T13:21:51Z
dc.date.available2025-04-08T13:21:51Z
dc.date.issued2024-06
dc.descriptionDATA AVAILABILITY STATEMENT: The data that support the findings of this study are available from the corresponding author upon reasonable request.en_US
dc.descriptionSUPPORTING INFORMATION: TABLE S1: Comparison of soluble immune checkpoint levels between female and male PLWH before ART; TABLE S2: Comparison of soluble immune checkpoint levels between female and male PLWH after 12 months of ART; TABLE S3: Comparison of the change in soluble immune checkpoint levels before and after 12 months of ART between tobacco-users and non-users; TABLE S4: Correlations between age and soluble immune checkpoint molecules before treatment in PLWH.en_US
dc.description.abstractPlease read abstract in article.en_US
dc.description.departmentImmunologyen_US
dc.description.departmentInternal Medicineen_US
dc.description.sdgSDG-03:Good heatlh and well-beingen_US
dc.description.sdgSDG-09: Industry, innovation and infrastructureen_US
dc.description.urihttps://www.mdpi.com/journal/pathogensen_US
dc.identifier.citationLabuschagne Naidoo, R.-B.; Steel, H.C.; Theron, A.J.; Anderson, R.; Tintinger, G.R.; Rossouw, T.M. Persistently Elevated Expression of Systemic, Soluble Co-Inhibitory Immune Checkpoint Molecules in People Living with HIV before and One Year after Antiretroviral Therapy. Pathogens 2024, 13, 540. https://doi.org/10.3390/pathogens13070540.en_US
dc.identifier.issn2076-0817 (online)
dc.identifier.other10.3390/pathogens13070540
dc.identifier.urihttp://hdl.handle.net/2263/101927
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rights© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).en_US
dc.subjectAntiretroviral treatmenten_US
dc.subjectCo-inhibitory immune checkpointsen_US
dc.subjectCTLA-4en_US
dc.subjectLAG-3en_US
dc.subjectPD-1en_US
dc.subjectPD-L1en_US
dc.subjectTIM-3en_US
dc.subjectSDG-03: Good health and well-beingen_US
dc.subjectSDG-09: Industry, innovation and infrastructureen_US
dc.subjectAntiretroviral therapy (ART)en_US
dc.subjectHuman immunodeficiency virus (HIV)en_US
dc.titlePersistently elevated expression of systemic, soluble co-inhibitory immune checkpoint molecules in people living with HIV before and one year after antiretroviral therapyen_US
dc.typeArticleen_US

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