Persistently elevated expression of systemic, soluble co-inhibitory immune checkpoint molecules in people living with HIV before and one year after antiretroviral therapy
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Date
Authors
Labuschagne Naidoo, Robyn-Brooke
Steel, Helen C.
Theron, Annette J.
Anderson, Ronald
Tintinger, Gregory Ronald
Rossouw, Theresa M.
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
Please read abstract in article.
Description
DATA AVAILABILITY STATEMENT: The data that support the findings of this study are available from the
corresponding author upon reasonable request.
SUPPORTING INFORMATION: TABLE S1: Comparison of soluble immune checkpoint levels between female and male PLWH before ART; TABLE S2: Comparison of soluble immune checkpoint levels between female and male PLWH after 12 months of ART; TABLE S3: Comparison of the change in soluble immune checkpoint levels before and after 12 months of ART between tobacco-users and non-users; TABLE S4: Correlations between age and soluble immune checkpoint molecules before treatment in PLWH.
SUPPORTING INFORMATION: TABLE S1: Comparison of soluble immune checkpoint levels between female and male PLWH before ART; TABLE S2: Comparison of soluble immune checkpoint levels between female and male PLWH after 12 months of ART; TABLE S3: Comparison of the change in soluble immune checkpoint levels before and after 12 months of ART between tobacco-users and non-users; TABLE S4: Correlations between age and soluble immune checkpoint molecules before treatment in PLWH.
Keywords
Antiretroviral treatment, Co-inhibitory immune checkpoints, CTLA-4, LAG-3, PD-1, PD-L1, TIM-3, SDG-03: Good health and well-being, SDG-09: Industry, innovation and infrastructure, Antiretroviral therapy (ART), Human immunodeficiency virus (HIV)
Sustainable Development Goals
SDG-03:Good heatlh and well-being
SDG-09: Industry, innovation and infrastructure
SDG-09: Industry, innovation and infrastructure
Citation
Labuschagne Naidoo, R.-B.;
Steel, H.C.; Theron, A.J.; Anderson, R.;
Tintinger, G.R.; Rossouw, T.M.
Persistently Elevated Expression of
Systemic, Soluble Co-Inhibitory
Immune Checkpoint Molecules in
People Living with HIV before and
One Year after Antiretroviral Therapy.
Pathogens 2024, 13, 540. https://doi.org/10.3390/pathogens13070540.