hERG, Plasmodium life cycle, and cross resistance profiling of new azabenzimidazole analogues of astemizole

dc.contributor.authorMambwe, Dickson
dc.contributor.authorCoertzen, Dina
dc.contributor.authorLeshabane, Meta Kgaogelo
dc.contributor.authorMulubwa, Mwila
dc.contributor.authorNjoroge, Mathew
dc.contributor.authorGibhard, Liezl
dc.contributor.authorGirling, Gareth
dc.contributor.authorWicht, Kathryn J.
dc.contributor.authorLee, Marcus C.S.
dc.contributor.authorWittlin, Sergio
dc.contributor.authorMoreira, Diogo Rodrigo Magalhaes
dc.contributor.authorBirkholtz, Lyn-Marie
dc.contributor.authorChibale, Kelly
dc.date.accessioned2024-07-25T07:10:15Z
dc.date.available2024-07-25T07:10:15Z
dc.date.issued2024-03
dc.descriptionSUPPLEMENTARY INFORMATION : Experimental procedures and characterization data of synthetic intermediates (5a–5f, 6a–6f, 13, and 15) and target compounds (7–12 and 15); biochemical assay protocols, including solubility and cross-resistance studies; H NMR spectra of representative target compounds.en_US
dc.description.abstractPlease read abstract in the article.en_US
dc.description.departmentBiochemistryen_US
dc.description.departmentGeneticsen_US
dc.description.departmentMicrobiology and Plant Pathologyen_US
dc.description.departmentUP Centre for Sustainable Malaria Control (UP CSMC)en_US
dc.description.librarianhj2024en_US
dc.description.sdgSDG-03:Good heatlh and well-beingen_US
dc.description.sponsorshipThe University of Cape Town (UCT), South African Medical Research Council, the South African Research Chairs Initiative (SARChI) of the Department of Science and Innovation (DSI) administered through the South African National Research Foundation (NRF), the Brazilian National Council for Scientific and Technological Development, Proep-Fiocruz Program (Brazil), the Neville Isdell Chair in African-centric Drug Discovery and Development, and Neville Isdell for generously funding the Chair.en_US
dc.description.urihttp://pubs.acs.org/journal/amclcten_US
dc.identifier.citationMambwe, D., Coertzen, D., Leshabane, M. et al. 2024, 'hERG, Plasmodium life cycle, and cross resistance profiling of new azabenzimidazole analogues of astemizole', ACS Medicinal Chemistry Letters, vol. 15, no. 4, pp. 463-469, doi : 10.1021/acsmedchemlett.3c00496.en_US
dc.identifier.issn1948-5875 (print)
dc.identifier.other10.1021/acsmedchemlett.3c00496
dc.identifier.urihttp://hdl.handle.net/2263/97228
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.rights© 2024 The Authors. Published by American Chemical Society. This article is licensed under CC-BY 4.0.en_US
dc.subjectAstemizoleen_US
dc.subjectPlasmodium falciparumen_US
dc.subjectPlasmodium bergheien_US
dc.subjectRepositioningen_US
dc.subjectHuman ether-á-go-go-related gene (hERG)en_US
dc.subjectGametocytocidalen_US
dc.subjectLiver-stage activityen_US
dc.subjectResistance phenotypesen_US
dc.subjectSDG-03: Good health and well-beingen_US
dc.titlehERG, Plasmodium life cycle, and cross resistance profiling of new azabenzimidazole analogues of astemizoleen_US
dc.typeArticleen_US

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