hERG, Plasmodium life cycle, and cross resistance profiling of new azabenzimidazole analogues of astemizole
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Date
Authors
Mambwe, Dickson
Coertzen, Dina
Leshabane, Meta Kgaogelo
Mulubwa, Mwila
Njoroge, Mathew
Gibhard, Liezl
Girling, Gareth
Wicht, Kathryn J.
Lee, Marcus C.S.
Wittlin, Sergio
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
Abstract
Please read abstract in the article.
Description
SUPPLEMENTARY INFORMATION : Experimental procedures and characterization data of synthetic intermediates (5a–5f, 6a–6f, 13, and 15) and target compounds (7–12 and 15); biochemical assay protocols, including solubility and cross-resistance studies; H NMR spectra of representative target compounds.
Keywords
Astemizole, Plasmodium falciparum, Plasmodium berghei, Repositioning, Human ether-á-go-go-related gene (hERG), Gametocytocidal, Liver-stage activity, Resistance phenotypes, SDG-03: Good health and well-being
Sustainable Development Goals
SDG-03:Good heatlh and well-being
Citation
Mambwe, D., Coertzen, D., Leshabane, M. et al. 2024, 'hERG, Plasmodium life cycle, and cross resistance profiling of new azabenzimidazole analogues of astemizole', ACS Medicinal Chemistry Letters, vol. 15, no. 4, pp. 463-469, doi : 10.1021/acsmedchemlett.3c00496.