The ascorbate-glutathione cycle coming of age

dc.contributor.authorFoyer, Christine H.
dc.contributor.authorKunert, Karl J.
dc.date.accessioned2025-04-15T10:38:15Z
dc.date.available2025-04-15T10:38:15Z
dc.date.issued2024-05-03
dc.descriptionDATA AVAILABILITY : This manuscript does not contain original dataen_US
dc.description.abstractConcepts regarding the operation of the ascorbate–glutathione cycle and the associated water/water cycle in the processing of metabolically generated hydrogen peroxide and other forms of reactive oxygen species (ROS) are well established in the literature. However, our knowledge of the functions of these cycles and their component enzymes continues to grow and evolve. Recent insights include participation in the intrinsic environmental and developmental signalling pathways that regulate plant growth, development, and defence. In addition to ROS processing, the enzymes of the two cycles not only support the functions of ascorbate and glutathione, they also have ‘moonlighting’ functions. They are subject to post-translational modifications and have an extensive interactome, particularly with other signalling proteins. In this assessment of current knowledge, we highlight the central position of the ascorbate– glutathione cycle in the network of cellular redox systems that underpin the energy-sensitive communication within the different cellular compartments and integrate plant signalling pathways.en_US
dc.description.departmentPlant Production and Soil Scienceen_US
dc.description.librarianam2024en_US
dc.description.sdgSDG-15:Life on landen_US
dc.description.sponsorshipThe BBSRC (UK) and NRF SA incentive funding.en_US
dc.description.urihttps://academic.oup.com/jxben_US
dc.identifier.citationFoyer, C.H. & Kunert, K. 2024, 'The ascorbate–glutathione cycle coming of age', Journal of Experimental Botany, vol. 75, no. 9, pp. 2682-2699. https://DOI.org/10.1093/jxb/erae023.en_US
dc.identifier.issn0022-0957 (print)
dc.identifier.issn1460-2431 (online)
dc.identifier.issn10.1093/jxb/erae023
dc.identifier.urihttp://hdl.handle.net/2263/102096
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.rights© The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution License.en_US
dc.subjectFoyer–Halliwell–Asada cycleen_US
dc.subjectHydrogen peroxideen_US
dc.subjectPhotosynthesisen_US
dc.subjectRedox signallingen_US
dc.subjectROS Waveen_US
dc.subjectSuperoxideen_US
dc.subjectStress acclimationen_US
dc.subjectReactive oxygen species (ROS)en_US
dc.subjectSDG-15: Life on landen_US
dc.titleThe ascorbate-glutathione cycle coming of ageen_US
dc.typeArticleen_US

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