The ascorbate-glutathione cycle coming of age
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Date
Authors
Foyer, Christine H.
Kunert, Karl J.
Journal Title
Journal ISSN
Volume Title
Publisher
Oxford University Press
Abstract
Concepts regarding the operation of the ascorbate–glutathione cycle and the associated water/water cycle in the
processing of metabolically generated hydrogen peroxide and other forms of reactive oxygen species (ROS) are
well established in the literature. However, our knowledge of the functions of these cycles and their component
enzymes continues to grow and evolve. Recent insights include participation in the intrinsic environmental and developmental
signalling pathways that regulate plant growth, development, and defence. In addition to ROS processing,
the enzymes of the two cycles not only support the functions of ascorbate and glutathione, they also have ‘moonlighting’
functions. They are subject to post-translational modifications and have an extensive interactome, particularly
with other signalling proteins. In this assessment of current knowledge, we highlight the central position of the ascorbate–
glutathione cycle in the network of cellular redox systems that underpin the energy-sensitive communication
within the different cellular compartments and integrate plant signalling pathways.
Description
DATA AVAILABILITY : This manuscript does not contain original data
Keywords
Foyer–Halliwell–Asada cycle, Hydrogen peroxide, Photosynthesis, Redox signalling, ROS Wave, Superoxide, Stress acclimation, Reactive oxygen species (ROS), SDG-15: Life on land
Sustainable Development Goals
SDG-15:Life on land
Citation
Foyer, C.H. & Kunert, K. 2024, 'The ascorbate–glutathione cycle coming of age', Journal of Experimental Botany, vol. 75, no. 9, pp. 2682-2699.
https://DOI.org/10.1093/jxb/erae023.