Abstract:
BACKGROUND. Despite enormous strides in preventing hepatitis B virus (HBV) infection, perinatal transmission still contributes significantly
to HBV epidemiology worldwide; this could account for approximately 50% of chronically infected individuals.
OBJECTIVE. To assess the need for HBV screening in antenatal clinics in the HIV/AIDS era.
METHODS. This was a retrospective study conducted at the antenatal clinic of 1 Military Hospital, Tshwane, South Africa. Laboratory data
for HBV, HIV and CD4 count were obtained and analysed for the period January 2008 - December 2013.
RESULTS. A total of 2 513 patients’ results were retrieved and 2 368 patients were enrolled as both their HBV and HIV serology results were
available. The mean age of participants was 29 years (range 14 - 46). HIV prevalence in this study was 20.5% (95% confidence interval
(CI) 0.189 - 0.222). The median CD4 count in HIV-infected patients was 522 cells/μL (interquartile range 370 - 711). There was an overall
HBV prevalence of 0.8% (95% CI 0.005 - 0.011). The hepatitis B surface antigen (HBsAg) prevalence was significantly higher (2.1%) among
HIV co-infected compared with HIV-uninfected patients (0.4%) (p=0.0001). Hepatitis e antigen (HBeAg) positivity was 30% in the HIV
co-infected compared with 37.6% in the HIV-uninfected individuals (p=0.7400).
CONCLUSION. This study showed a significantly higher HBV prevalence in HIV-infected compared with HIV-uninfected patients. The
comparable HBeAg prevalence between the two groups indicates that both were at an increased risk of vertical transmission, therefore
demonstrating a need for antenatal screening for HBV. Since antenatal screening is often not affordable in low-income countries,
administration of HBV vaccine at birth is needed for prevention of vertical transmission.
