Browsing Medical Oncology by Issue Date

Now showing items 1-20 of 74

The effect of metal based complexes on the survival of aerobic and hypoxic chinese hamster ovary cells, in vitro.

Falzone, Nadia (University of Pretoria, 2007-03-03)

It is well established that many solid tumours are heterogeneous with respect to oxygenation, and contain regions of hypoxic cells, which due to their inherent resistance to ionizing radiation, limit the success of ...
A comparison of radiotherapy techniques for the irradiation of the whole scalp

Viviers, Emma Victoria (University of Pretoria, 2010)

No abstract available.
Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia

Saglio, Giuseppe; Kim, Dong-Wook; Issaragrisil, Surapol; Le Coutre, Philipp; Etienne, Gabriel; Lobo, Clarisse; Pasquini, Ricardo; Clark, Richard E.; Hochhaus, Andreas; Hughes, Timothy P.; Gallagher, Neil; Hoenekopp, Albert; Dong, Mei; Haque, Ariful; Larson, Richard A. (Massachusetts Medical Society, 2010-06)

BACKGROUND: Nilotinib has been shown to be a more potent inhibitor of BCR-ABL than imatinib. We evaluated the efficacy and safety of nilotinib, as compared with imatinib, in patients with newly diagnosed Philadelphia ...
Quality of life in patients with metastatic breast cancer : A South African perspective

Mertz, Magaretha Susara (University of Pretoria, 2010-10-06)

Please read the abstract in the section 00front of this document
Recommendations for the management of adult chronic myeloid leukaemia in South Africa

Louw, V.J.; Dreosti, Lydia M.; Ruff, P.; Jogessar, V.; Moodley, D.; Novitzky, N.; Patel, M.; Schmidt, A.; Willem, Pascale (Health and Medical Publishing Group, 2011-11)

INTRODUCTION: Chronic myeloid leukaemia (CML) is a chronic myeloproliferative disorder characterised by a chromosomal translocation between the long arms of chromosomes 9 and 12 resulting in the formation of the BCR-ABL ...
Guideline for the treatment of myelodysplastic syndromes (MDS) in South Africa

Louw, V.J.; Bassa, F.; Chan, S.W.; Dreosti, Lydia M.; Du Toit, M.; Ferreira, M.; Gartrell, K.; Gunther, K.; Jogessar, V.; Littleton, N.; Mahlangu, J.; McDonald, A.; Patel, M.; Pool, Roger; Ruff, P.; Schmidt, A.; Sissolak, G.; Swart, Andre; Verburgh, E.; Webb, M.J. (Health and Medical Publishing Group, 2011-12)

INTRODUCTION: Myelodysplastic syndromes (MDS) encompass a heterogeneous group of clonal haematopoietic disorders characterised by chronic and progressive cytopenias resulting from ineffective haematopoiesis. Treatment ...
Venous thrombosis in the patient with cancer

Wessels, Pieter Frederik (Open Journals Systems, 2012)

The relationship between cancer and thrombosis has been known for many years. Thrombotic risk is increased in the patient with cancer, and the diagnosis of venous thromboembolism at the time that a malignancy presents ...
Comparing target volumes used in radiotherapy planning based on CT and PET/CT lung scans with and without respiratory gating applied

Du Plessis, Tamarisk (University of Pretoria, 2012)

A study was done at Steve Biko Academic hospital to determine the influence that respiratory gating will have on target volumes used in radiotherapy treatment planning. The primary objective was to compare target volumes ...
Anticoagulation therapy in diabetic patients

Wessels, Pieter Frederik (Clinics Cardiv, 2012-03)

Diabetic patients have a high risk of developing arterial disease (coronary artery, cerebrovascular and peripheral arterial disease) and are therefore often given antiplatelet therapy. Although only retrospective studies ...
Venous thromboembolism : prophylactic and therapeutic practice guideline

Jacobson, B.F.; Louw, S.; Buller, H.; Mer, M.; De Jong, P.R.; Rowji, P.; Schapkaitz, E.; Adler, D.; Beeton, A.; Hsu, H-C.; Wessels, Pieter Frederik; Haas, S. (Health and Medical Publishing Group, 2013-04)

BACKGROUND: Pharmacological prophylactic anticoagulation in many countries, including South Africa, is under-prescribed. This has resulted in unacceptable rates of morbidity and mortality. METHOD: The Southern African ...
Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO) : survival outcomes of a randomised, open-label, multicentre, phase 3 trial and their association with pathological complete response

De Azambuja, Evandro; Holmes, Andrew P.; Piccart-Gebhart, Martine; Holmes, Eileen; Di Cosimo, Serena; Swaby, Ramona; Untch, Michael; Jackisch, Christian; Lang, Istvan; Smith, Ian; Boyle, Frances; Xu, Binghe; Barrios, Carlos H.; Perez, Edith A.; Azim Jr., Hatem A.; Kim, Sung-Bae; Kuemmel, Sherko; Huang, Chiun-Sheng; Vuylsteke, Peter; Hsieh, Ruey-Kuen; Gorbunova, Vera; Eniu, Alexandru; Dreosti, Lydia M.; Tavartkiladze, Natalia; Gelber, Richard D.; Eidtmann, Holger; Baselga, José (Elsevier, 2014-09)

BACKGROUND : We investigated whether the increase in pathological complete response (pCR) rates with neoadjuvant combination of lapatinib and trastuzumab in addition to weekly paclitaxel would translate into improved survival ...
Mortality amongst patients with influenza - associated severe acute respiratory illness, South Africa, 2009-2013

Cohen, Cheryl; Moyes, Jocelyn; Tempia, Stefano; Groome, Michelle; Walaza, Sibongile; Pretorius, Marthinus W.; Dawood, Halima; Chhagan, Meera; Haffejee, Summaya; Variava, Ebrahim; Kahn, Kathleen; Von Gottberg, Anne; Wolter, Nicole; Cohen, Adam L.; Malope-Kgokong, Babatyi; Venter, Marietjie; Madhi, Shabir A. (Public Library of Science, 2015-03-18)

INTRODUCTION Data on the burden and risk groups for influenza-associated mortality from Africa are limited. We aimed to estimate the incidence and risk-factors for in-hospital influenza-associated severe acute respiratory ...
Combination of everolimus with trastuzumab plus paclitaxel as first-line treatment for patients with HER2-positive advanced breast cancer (BOLERO-1) : a phase 3, randomised, double-blind, multicentre trial

Hurvitz, Sara A.; Andre, Fabrice; Jiang, Zefei; Shao, Zhimin; Mano, Max S.; Neciosup, Silvia P.; Tseng, Ling-Min; Zhang, Qingyuan; Shen, Kunwei; Liu, Donggeng; Dreosti, Lydia M.; Burris, Howard A.; Toi, Masakazu; Buyse, Marc E.; Cabaribere, David; Lindsay, Mary-Ann; Rao, Shantha; Pacaud, Lida Bubuteishvili; Taran, Tetiana; Slamon, Dennis (Elsevier, 2015-07)

BACKGROUND : mTOR inhibition has been shown to reverse trastuzumab resistance from hyperactivated the PIK/AKT/mTOR pathway due to PTEN loss, by sensitizing PTEN-deficient tumors towards trastuzumab. The BOLERO-1 study ...
Randomized phase III trial of consolidation therapy with bortezomib–lenalidomide–Dexamethasone (VRd) vs bortezomib–dexamethasone (Vd) for patients with multiple myeloma who have completed a dexamethasone based induction regimen

Jacobus, S.J.; Rajkumar, S.V.; Weiss, M.; Stewart, A.K.; Stadtmauer, E.A.; Callander, N.S.; Dreosti, Lydia M.; Lacy, M.Q.; Fonseca, R. (Nature Publishing Group, 2016)

Long-awaited results from the the Southwest Oncology Group (SWOG) trial comparing bortezomib–lenalidomide-dexamethasone (VRd) versus lenalidomide-dexamethasone (Rd) as induction treatment for previously untreated multiple ...
Thromboprophylaxis in spinal surgery : a survey of current practice in South Africa

Jacobs, H.W. (Hans); Zondagh, Ian; Wessels, Pieter Frederik (South African Orthopaedic Association, 2017)

BACKGROUND : Patients undergoing spinal surgery are at risk of developing venous thromboembolism (VTE) because of co-morbidities and immobilisation, but the morbidity of bleeding and haematoma formation complicates prophylaxis. ...
Acute megakaryoblastic leukaemia: light microscopy and scanning electron microscopy of blast cells

Masingi, Ntsakisi I.; Laher, Zaheer; Pretorius, Etheresia (Wiley, 2017-03)

A 60-year-old human immunodeficiency virus-positive woman presented with splenomegaly.
Survival of patients with Kaposi’s sarcoma in the South African antiretroviral treatment era : a retrospective cohort study

Sengayi, M.M.; Egger, M.; Dreosti, Lydia M.; Bohlius, J. (Health and Medical Publishing Group, 2017-10)

BACKGROUND : When South Africa (SA) implemented its antiretroviral therapy (ART) programme in 2004, the model for treating HIV-positive Kaposi’s sarcoma (KS) patients shifted from symptomatic palliation to potential ...
Regulation of alternative splicing in obesity-induced hypertension

Dlamini, Zodwa; Hull, Rodney; Makhafola, Tshepiso Jan; Mbele, Mzwandile (Dove Medical Press, 2019)

Obesity is the result of genetics which predisposes an individual to obesity and environmental factors, resulting in excessive weight gain. A well-established linear relationship exists between hypertension and obesity. ...
Possible effects of HIV infection on overall survival of patients diagnosed with acute myeloid leukaemia

Dyer, Greg Bryan (University of Pretoria, 2019)

Background The effects of Human Immunodeficiency Virus (HIV) on the Overall Survival (OS) in patients diagnosed with Acute Myeloid Leukaemia (AML) are not well documented. All studies to date have been with small sample ...
Patient blood management : a solution for South Africa

Thomson, J.; Hofmann, A.; Barrett, C.A.; Beeton, A.; Bellairs, G.R.M.; Boretti, L.; Coetzee, M.J.; Farmer, S.; Gibbs, M.W.; Gombotz, H.H.; Hilton, C.; Kassianides, C.; Louw, V.J.; Lundgren, C.; Mahlangu, J.N.; Noel, C.B.; Rambiritch, V.; Schneider, F.; Verburgh, E.; Wessels, P.-L.; Wessels, Pieter Frederik; Wise, R.; Shander, A. (Health and Medical Publishing Group, 2019-07)

For more than 70 years the default therapy for anaemia and blood loss was mostly transfusion. Accumulating evidence demonstrates a significant dose-dependent relationship between transfusion and adverse outcomes. This and ...

Now showing items 1-20 of 74

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