• Antimicrobial, synergistic and autophagic effects of medicines for Malaria venture pathogen box compounds on resistant strains of Mycobacterium tuberculosis and Neisseria gonorrhoeae 

  Mensah, Eric (University of Pretoria, 2023)

  Antimicrobial resistance in Mycobacterium tuberculosis and Neisseria gonorrhoeae is emerging globally. Due to the limited treatment options, the World Health Organization has designated M. tuberculosis and N. gonorrhoeae ...
• Genotypic profiles of emerging multidrug-resistant Staphylococcus capitis isolates from an ongoing outbreak in critically ill patients 

  Mynhardt, Barend J. (University of Pretoria, 2023)

  An increasing number of linezolid resistant (LZR), multidrug-resistant (MDR) Staphylococcus capitis infections have been observed in private hospitals in the greater Gauteng area since 2014. The aim of this study was to ...
• Molecular characterisation of β-lactamase producing Klebsiella pneumoniae isolates 

  De Jesus, Marissa Batista (University of Pretoria, 2015)

  Genetic typing of Klebsiella pneumoniae is used for epidemiological referencing. In the clinical setting it can be useful in outbreak investigations, understanding transmission and managing hospital infections. Multi-drug ...
• Molecular epidemiology and mechanisms of colistin and carbapenem resistance in Enterobacteriaceae from clinical isolates, the environment and porcine samples in Pretoria, South Africa 

  Bogoshi, Dineo (University of Pretoria, 2020)

  Introduction: Carbapenems and colistin are the last-line antibiotics for treating Gram-negative bacterial infections. However, increasing reports of resistance to these antibiotics is being reported in clinical settings, ...
• Phenotypic and genotypic characterization of isoniazid resistance mutations in Mycobacterium tuberculosis isolates from new and previously treated patients in the Tshwane region 

  Sinthumule, Ndivhudzannyi Peace (University of Pretoria, 2020)

  Background: Isoniazid (INH) is one of the most potent anti-tuberculosis (TB) drugs and a key component of the multi-drug regimen for the treatment of TB. Tuberculosis cases with initial INH resistance are more at risk ...
• Evaluation of single nucleotide polymorphisms in virulence genes of Mycobacterium tuberculosis as markers of lineages and sub-lineages in Tshwane region 

  Matodzi, Unarine (University of Pretoria, 2020)

  Tuberculosis (TB) is one of the top ten leading causes of death worldwide with millions of new TB cases reported every year. Understanding the genetic diversity of Mycobacterium tuberculosis (M. tuberculosis) is very ...
• Genotypic and phenotypic diversity of Mycobacterium tuberculosis strains in patients with concomitant pulmonary and extra-pulmonary tuberculosis 

  Sibandze, Busizwe Busizwe (University of Pretoria, 2019)

  future, more robust or higher-resolution genomic typing tools, such as target Next Generation Sequencing (t-NGS) or metagenomic analysis are recommended to improve our understanding of the complexity of infections and for ...
• The association between genital mycoplasmas and bacterial vaginosis in pregnant women with or without genital symptoms 

  Redelinghuys, Mathys J. (University of Pretoria, 2014)

  Bacterial vaginosis (BV) and genital mycoplasmas are infections of the reproductive tract that play important roles in maternal and foetal health. Genital mycoplasmas include Mycoplasma genitalium, M. hominis, Ureaplasma ...
• Genetic diversity of methicillin resistant Staphylococcus aureus strains in the Pretoria region in South Africa 

  Salawu, Adeola Mujidat (University of Pretoria, 2014)

  Staphylococcus aureus (S. aureus) is one of the leading causes of human diseases in hospital and community settings. Methicillin resistant Staphylococcus aureus (MRSA) has emerged as a significant problem worldwide, resisting ...
• Trichomonas vaginalis and bacterial co-infections identified in reproductive age women 

  Sethowa, Jonas Tshoene (University of Pretoria, 2017)

  Sexually transmitted infections (STIs) continue to be a significant public health problem with an increased burden on women of reproductive age. These infections can be transmitted between humans by means of sexual ...
• Evaluation of Mycobacterium tuberculosis clinical isolates with discordant rifampicin genotypic and phenotypic susceptibility testing results from Pretoria South Africa 

  Marubini, Elelwani Elliot (University of Pretoria, 2016)

  Background. In recent years, there has been an alarming increase in cases of multidrug-resistant tuberculosis (MDR-TB), and also extensively drug-resistant tuberculosis (XDR-TB). The emergence of these forms of tuberculosis ...
• Association of Mycobacterium tuberculosis genotypes and treatment outcome in pulmonary tuberculosis patients in Tshwane Metropolitan area 

  Matukane, Siphiwe Ruthy (University of Pretoria, 2015)

  Tuberculosis (TB) is a major cause of death worldwide, especially in Asia and Africa. Genotyping methods such as insertion sequence 6110-restriction fragment length polymorphism (IS6110-RFLP), spoligotyping and mycobacterial ...
• The antimicrobial effect of colistin methanesulfonate (polymyxin E) on Mycobacterium tuberculosis in vitro 

  Van Breda, Shane Vontelin (University of Pretoria, 2016)

  Polymyxins have previously been described to have activity against M. tuberculosis (M. tb), but further research was abandoned due to systemic toxicity concerns to achieve the required MIC. Colistin methanesulfonate (CMS), ...
• Innovative approaches to tuberculosis diagnosis with emphasis on nucleic acid amplification tests in a resource constrained high burden tuberculosis setting 

  Omar, Shaheed Vally (University of Pretoria, 2015)

  The global control of tuberculosis (TB) is currently hindered by the low sensitivity of microscopy and the prolonged time-to-result of culture. Recent technical progress has improved both diagnostic accuracy and turnaround, ...
• Phenotypic and genotypic susceptibility testing of Mycobacterium tuberculosis cultures from Tshwane Metropolitan area 

  Atanda, Oluwasegun Olayinka (University of Pretoria, 2015)
• Characterisation and detection of Mycobacterium tuberculosis in pleural biopsies using Proteomics and Molecular techniques 

  Mohlabeng, Mokgadi Ruth (University of Pretoria, 2014)

  Tuberculosis (TB) remains a major global health problem. In 2012, an estimated 8.6 million people developed TB and 1.3 million died from the disease (including 320 000 deaths among HIV-positive people). All countries are ...
• Phenotypic and molecular antifungal susceptibility testing of yeast isolates from Pretoria 

  Hnaya, Maren (University of Pretoria, 2013)

  Antifungal drug resistance is a growing problem. Several mechanisms contribute to the development of resistance to antifungal agents. In South Africa, little is known about the antifungal susceptibility of local yeast ...
• Genetic relatedness of Mycobacterium tuberculosis strains obtained from Kalafong Hospital in Pretoria using Spoligotyping and MIRU-VNTR typing 

  Bulane, Atang (University of Pretoria, 2012-12-14)

  Every year close to 9 million people contract tuberculosis (TB) and approximately 2 million die from the disease. The highest number of TB cases is in Asia while Africa has the highest incidence rates due to high rates ...
• Ausceptibility testing and resistance mechanisms to second-line agents against Mycobacterium tuberculosis in Pretoria, South Africa 

  Said, H.M. (Halima Mohammed) (University of Pretoria, 2012-10-01)

  Multidrug-resistant (MDR) and extensively drug-resistant tuberculosis (XDR-TB) is a serious problem in South Africa. Standardised and accurate drug susceptibility testing for first-line and second-line anti-TB drugs are ...
• Detection and characterization of ESBL positive Klebsiella pneumoniae clinical isolates 

  Manenzhe, Gumanzi Isaac (University of Pretoria, 2012-08-14)

  Klebsiella pneumoniae is an important nosocomial pathogen that has the potential to cause severe morbidity and mortality, particularly in intensive care units, as well as in medical and surgical wards. In recent years, ...

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