• Clinical validation of loop-mediated isothermal amplification for the detection of Escherichia coli sequence type complex 131 

  Peirano, G.; Castellanos, L. Ricardo; Matsumura, Yasufumi; Chaffee, Ryan; Castaneda-Mogollon, Daniel; Pillai, Dylan R.; Pitout, Johann D.D. (American Society for Microbiology, 2024-03)

  The dissemination of Escherichia coli multidrug-resistant (MDR) STc131 is related to its persistence in the human gastrointestinal tract as efficient gut colonizers. Infection and prevention measures are the cornerstones ...
• Low prevalence of Schistosoma haematobium infection in pregnant women in Buffalo City district 

  Peters, Remco P.H.; Mdingi, Mandisa; Jung, Hyunsul; Mukomana, Freedom; Gigi, Ranjana M. S.; Medina‑Marino, Andrew; Klausner, Jeffrey D (AOSIS, 2023-06-15)

  No abstract available.
• The importance of the individual in PrEP uptake : multilevel correlates of PrEP uptake among adolescent girls and young women in Tshwane, South Africa 

  Bonner, Courtney Peasant; Minnis, Alexandra M.; Ndirangu, Jacqueline W.; Browne, Felicia A.; Speizer, Ilene; Nyblade, Laura; Ahmed, Khatija; Wechsberg, Wendee M. (Springer, 2023-12)

  Adolescent girls and young women (AGYW) account for 25% of new HIV infections in South Africa. Pre-exposure prophylaxis (PrEP) is approved by the South African Government, but the factors that promote PrEP uptake among ...
• Incorporating end-users' voices into the development of an implant for HIV prevention : a discrete choice experiment in South Africa and Zimbabwe 

  Browne, Erica N.; Manenzhe, Kgahlisho; Makoni, Wanzirai; Nkomo, Sikhanyisiwe; Mahaka, Imelda; Ahmed, Khatija; Shapley‑Quinn, Mary Kate; Marton, Tozoe; Luecke, Ellen; Johnson, Leah; Van der Straten, Ariane; Minnis, Alexandra M. (BMC, 2023-02-10)

  BACKGROUND : Input from end-users during preclinical phases can support market fit for new HIV prevention technologies. With several long-acting pre-exposure prophylaxis (PrEP) implants in development, we aimed to ...
• Vulvovaginal yeast infections during pregnancy and perinatal outcomes : systematic review and meta-analysis 

  Gigi, Ranjana M. S.; Buitrago‑Garcia, Diana; Taghavi, Katayoun; Dunaiski, Cara‑Mia; Van de Wijgert, Janneke H.H.M.; Peters, Remco P.H.; Low, Nicola (BMC, 2023-03-21)

  BACKGROUND : Vulvovaginal yeast infections in pregnancy are common and can cause extensive inflammation, which could contribute to adverse pregnancy outcomes. Symptomatic yeast infections are likely to cause more ...
• Genital tract infections, the vaginal microbiome and gestational age at birth among pregnant women in South Africa : a cohort study protocol 

  Gigi, Ranjana M. S.; Mdingi, Mandisa M.; Jung, Hyunsul; Claassen-Weitz, Shantelle; Butikofer, Lukas; Klausner, Jeffrey D; Muzny, Christina A.; Taylor, Christopher M.; Van de Wijgert, Janneke H.H.M.; Peters, Remco P.H.; Low, Nicola (BMJ Publishing Group, 2023-12)

  INTRODUCTION : Preterm birth complications are the most common cause of death in children under 5 years. The presence of multiple microorganisms and genital tract inflammation could be the common mechanism driving early ...
• Characterization of Salmonella enterica serovar Isangi from South Africa, 2020–2021 

  Myataza, Asive; Thomas, Juno; Smith, Anthony M. (BMC, 2023-11)

  BACKGROUND : We describe the genotypic characteristics and antimicrobial resistance (AMR) determinants of Salmonella enterica serovar Isangi (Salmonella Isangi) clinical isolates in South Africa from 2020 through ...
• Molecular investigations of Mycobacterium tuberculosis genotypes among baseline and follow-up strains circulating in four regions of Eswatini 

  Dlamini, Talent C.; Mkhize, Brenda T.; Sydney, Clive; Maningi, Nontuthuko E.; Malinga, Lesibana Anthony (BMC, 2023-08-29)

  BACKGROUND : The tuberculosis (TB) epidemic remains a major global health problem and Eswatini is not excluded. Our study investigated the circulating genotypes in Eswatini and compared them at baseline (start of ...
• Population-based genomic surveillance of Pseudomonas aeruginosa causing bloodstream infections in a large Canadian health region 

  Peirano, Gisele; Matsumara, Yasufumi; Nobrega, Diego; Church, Deirdre; Pitout, Johann D.D. (Springer, 2024-03)

  Please read abstract in the article.
• Potential for maternally administered vaccine for infant group B streptococcus 

  Madhi, Shabir A.; Anderson, Annaliesa S.; Absalon, Judith; Radley, David; Simon, Raphael; Jongihlati, Babalwa; Strehlau, Renate; Van Niekerk, Anika M.; Izu, Alane; Naidoo, Niree; Kwatra, Gaurav; Ramsamy, Yogandree; Said, Mohamed; Jones, Stephanie; Jose, Lisa; Fairlie, Lee; Barnabas, Shaun L.; Newton, Ryan; Munson, Samantha; Jefferies, Zahra; Pavliakova, Danka; Silmon de Monerri, Natalie C.; Gomme, Emily; Perez, John L.; Scott, Daniel A.; Gruber, William C.; Jansen, Kathrin U. (Massachusetts Medical Society, 2023-07)

  BACKGROUND : Natural history studies have correlated serotype-specific anti–capsular polysaccharide (CPS) IgG in newborns with a reduced risk of group B streptococcal disease. A hexavalent CPS–cross-reactive material 197 ...
• Incidence of respiratory syncytial virus-associated lower respiratory tract illness in infants in low- and middle-income regions during the Coronavirus disease 2019 pandemic 

  Fry, Samantha; Chokephaibulkit, Kulkanya; Pallem, Sridevi; Henry, Ouzama; Pu, Yongjia; Akawung, Agnes; Kim, Joon Hyung; Yanni, Emad; Tullio, Antonella Nadia; Aurpibul, Linda; Lee, Christine Mui Fong; Ceballos, Ana; Zaman, Khalequ; Abadia de Regalado, Ivonne; Ahmed, Khatija; Arias Fernandez, Diana Andrea; Taher, Sri Wahyu; Caccavo, Juliana; Coutinho, Conrado Milani; D'Andrea Nores, Ulises; De Leon, Tirza; D'Silva, Emily Christine; De Bernardi, Mara; Dieser, Pablo; Falaschi, Andrea; Flores Acosta, Clara del Carmen; Gentile, Angela; Teo, Ik Hui; Kotze, Sheena; Lopez-Medina, Eduardo; Luca, Ruben; Lucion, Maria Florencia; Mantaring, Jacinto Blas V., III; Marin, Bladimir; Moelo, Malahleha; Mussi-Pinhata, Marisa Marcia; Pinto, Jorge; Puthanakit, Thanyawee; Reyes, Osvaldo; Roa, Maria Fernanda; Rodriguez Brieschke, Maria Teresa; Rodriguez, Camilo Enrique; Rodriguez Nino, Juan Nicolas; Schwarzbold, Alexandre Vargas; Sierra Garcia, Alexandra; Sivapatham, Lavitha; Soon, Ruey; Tinoco, Juan Carlos; Velasquez Penagos, Jesus Arnulfo; Dos Santos, Gael (Oxford University Press, 2023-12)

  BACKGROUND : Incidence data of respiratory syncytial virus–associated lower respiratory tract illness (RSV-LRTI) are sparse in low- and middle-income countries (LMICs). We estimated RSV-LRTI incidence rates (IRs) in infants ...
• A call to standardize the definition and method of assessing women for vaginal discharge syndrome in pregnancy 

  Babalola, Chibuzor M.; Peters, Remco P.H.; Mukomana, Freedom; Mdingi, Mandisa; Gigi, Ranjana M.S.; Muzny, Christina A.; Taylor, Christopher M.; Medina-Marino, Andrew; Klausner, Jeffrey D (Oxford University Press, 2023-04)

  No abstract available.
• Exploring a community's understanding of HIV vaccine-induced seropositivity in a South African research setting 

  Malahleha, M.; Dilraj, A.; Jean, J.; Morar, N.S.; Dietrich, J.J.; Ross, M.; Mbatsane, E.; Keefer, M.C.; Ahmed, Khatija (South African Medical Association, 2023-01)

  BACKGROUND. The high HIV prevalence and incidence in South Africa makes it suitable for recruitment of participants for large-scale HIV preventive vaccine trials. However, fear of vaccine-induced seropositivity (VISP) may ...
• Doxycycline post-exposure prophylaxis for sexually transmitted infections in South Africa 

  Peters, Remco P.H.; McIntyre, James A.; Garrett, N.; Brink, Adrian J.; Celum, Connie L.; Bekker, Linda‑Gail (AOSIS, 2023-09-28)

  South Africa has a large burden of bacterial sexually transmitted infections (STIs) with high rates among men who have sex with men (MSM). Randomised controlled trials have recently demonstrated high effectiveness of ...
• Implementation considerations for a point-of-care Neisseria gonorrhoeae rapid diagnostic test at primary healthcare level in South Africa : a qualitative study 

  De Vos, Lindsey; Daniels, Joseph; Gebengu, Avuyonke; Mazzola, Laura; Gleeson, Birgitta; Blumel, Benjamin; Piton, Jérémie; Mdingi, Mandisa; Gigi, Ranjana M.S.; Ferreyra, Cecilia; Klausner, Jeffrey D.; Peters, Remco P.H. (BMC, 2024-01)

  BACKGROUND : South Africa maintains an integrated health system where syndromic management of sexually transmitted infections (STI) is the standard of care. An estimated 2 million cases of Neisseria gonorrhoeae (N. ...
• Multicountry study of SARS-CoV-2 and associated risk factors among healthcare workers in Cote d’Ivoire, Burkina Faso and South Africa 

  Kribi, Sarah; Toure, Fidele; Mendes, Adriano; Sanou, Soufiane; Some, Arsene; Aminou, Abdoul M.; Belarbi, Essia; Griessel, Rosemary; Hema, Arsene; Kabore, Firmin; Pitzinger, Paul; Strydom, Amy; Vietor, Ann Christin; Traore, Korotimi; Zongo, Arsene; Anoh, Etile A.; Grossegesse, Marica; Hofmann, Natalie; Ouangraoua, Soumeya; Poda, Armel; Kagone, Therese; Schubert, Grit; Eckmanns, Tim; Venter, Marietjie; Leendertz, Fabian; Akoua-Koffi, Chantal; Tomczyk, Sara (Oxford University Press, 2023-03)

  BACKGROUND : Reports on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread across Africa have varied, including among healthcare workers (HCWs). This study assessed the comparative SARS-CoV-2 burden and ...
• A case report of Nocardia asiatica constrictive pericarditis in a patient with Human Immunodeficiency Virus 

  Griessel, Rosemary; Mitton, Barend C.; Rule, Roxanne; Said, Mohamed (Elsevier, 2022-05)

  Nocardiosis commonly affects the respiratory system and is a rare cause of purulent pericarditis. Invasive nocardial infections occur more frequently in patients with immunosuppression. A misdiagnosis as tuberculosis ...
• Antimicrobial resistance patterns of Acinetobacter baumannii and Klebsiella pneumoniae isolated from dogs presented at a veterinary academic hospital in South Africa 

  Sebola, Dikeledi; Oguttu, James W.; Kock, Marleen M.; Qekwana, Daniel Nenene (Veterinary World, 2023-09-17)

  BACKGROUND : Acinetobacter baumannii and Klebsiella pneumoniae are opportunistic bacterial pathogens responsible for hospital-acquired infections in veterinary medicine. Infection with these bacteria always requires urgent ...
• CD4+ T cell responses to Toxoplasma gondii are a double-edged sword 

  El Bissati, Kamal; Krishack, Paulette A.; Zhou, Ying; Weber, Christopher R.; Lykins, Joseph; Jankovic, Dragana; Edelblum, Karen L.; Fraczek, Laura; Grover, Harshita; Chentoufi, Aziz Alami; Singh, Gurminder; Reardon, Catherine; Dubey, J.P.; Reed, Steve; Alexander, Jeff; Sidney, John; Sette, Alessandro; Shastri, Nilabh; McLeod, Rima (MDPI, 2023-09-14)

  CD4+ T cells have been found to play critical roles in the control of both acute and chronic Toxoplasma infection. Previous studies identified a protective role for the Toxoplasma CD4+ T celleliciting peptide AS15 ...
• Emergence of canonical and non-canonical genomic variants following in vitro exposure of clinical Mycobacterium tuberculosis strains to bedaquiline or clofazimine 

  Ismail, Nazir Ahmed; Dippenaar, Anzaan; Warren, R.M.; Peters, Remco P.H.; Omar, Shaheed V. (American Society for Microbiology, 2023-04)

  In Mycobacterium tuberculosis, bedaquiline and clofazimine resistance occurs primarily through Rv0678 variants, a gene encoding a repressor protein that regulates mmpS5/mmpL5 efflux pump gene expression. Despite the shared ...

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