Browsing Obstetrics and Gynaecology by UP Author "Hull, Rodney"

Browsing Obstetrics and Gynaecology by UP Author "Hull, Rodney"

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  • Artificial intelligence (AI) and big data in cancer and precision oncology 
    Dlamini, Zodwa; Francies, Flavia Zita; Hull, Rodney; Marima, Rahaba (Elsevier, 2020)
    Artificial intelligence (AI) and machine learning have significantly influenced many facets of the healthcare sector. Advancement in technology has paved the way for analysis of big datasets in a cost- and time-effective ...
  • The catastrophic HPV/HIV dual viral oncogenomics in concert with dysregulated alternative splicing in cervical cancer 
    Marima, Rahaba; Hull, Rodney; Lolas, Georgios; Syrigos, Konstantinos N.; Kgoebane-Maseko, Minah; Kaufmann, Andreas Martin; Dlamini, Zodwa (MDPI Publishing, 2021-09-18)
    Cervical cancer is a public health problem and has devastating effects in low-to-middle income countries (LTMICs) such as the sub-Saharan African (SSA) countries. Infection by the human papillomavirus (HPV) is the main ...
  • Cervical cancer in low and middle‑income countries 
    Hull, Rodney; Mbele, Mzwandile; Makhafola, Tshepiso Jan; Hicks, Chindo; Wang, Shao Ming; Reis, Rui Manuels; Mehrotra, Ravi; Mkhize-Kwitshana, Zilungile; Kibiki, Gibson; Bates, David O.; Dlamini, Zodwa (Spandidos, 2020)
    Cervical cancer is a malignant tumour that occurs in the cervix and is classified into two histological types, adenocarcinoma and squamous cell carcinoma (SCC); SCC is more common and accounts for 70% of all cases. In 2018 ...
  • Expression analysis of RbBP6 in human cancers : a prospective biomarker 
    Mbita, Zukile; Hull, Rodney; Mbele, Mzwandile; Makhafola, Tshepiso Jan; Dlamini, Zodwa (Lippincott, Williams and Wilkins, 2019-09)
    Retinoblastoma binding protein 6 (RBBP6) is a cancer-related protein that has been implicated in the regulation of cell cycle and apoptosis. RBBP6 isoform 1 has been demonstrated to interact with two tumour suppressors, ...
  • HIV-associated cancer biomarkers : a requirement for early diagnosis 
    Dlamini, Zodwa; Mbele, Mzwandile; Makhafola, Tshepiso J.; Hull, Rodney; Marima, Rahaba (MDPI Publishing, 2021-07-29)
    Globally, HIV/AIDS and cancer are increasingly public health problems and continue to exist as comorbidities. The sub-Saharan African region has the largest number of HIV infections. Malignancies previously associated ...
  • Long non-coding RNAs (LncRNAs), viral oncogenomics, and aberrant splicing events : therapeutics implications 
    Hull, Rodney; Mbita, Zukile; Dlamini, Zodwa (e-Century Publishing, 2021-03-15)
    It has been estimated that worldwide up to 10% of all human cancers are the result of viral infection, with 7.2% of all cancers in the developed world have a viral aetiology. In contrast, 22.9% of infections in the developing ...
  • A multinational review : oesophageal cancer in low to middle-income countries 
    Hull, Rodney; Mbele, Mzwandile; Makhafola, Tshepiso Jan; Hicks, Chindo; Wang, Shao Ming; Reis, Rui Manuels; Mehrotra, Ravi; Mkhize-Kwitshana, Zilungile; Hussain, Showket; Kibiki, Gibson; Bates, David O.; Dlamini, Zodwa (Spandidos, 2020-10)
    Oesophageal cancer (OC) is an aggressive neoplasm that manifests in the gastrointestinal tract and is the result of numerous factors that can contribute to the development of the disease. These may include old age, nutritional ...
  • RBBP6 interactome : RBBP6 isoform 3/DWNN and Nek6 interaction is critical for cell cycle regulation and may play a role in carcinogenesis 
    Mbita, Zukile; Hull, Rodney; Mokoena, Fortunate; Lai, Chin-Hung; Dlamini, Zodwa (Elsevier, 2021)
    RBBP6 is a multidomain protein, with four splice variants translated into four functional isoforms. RBBP6 isoform 1 has been reported to interact with TP53 and pRb as well as with proteins that regulate transcriptional ...
  • Regulation of alternative splicing in obesity-induced hypertension 
    Dlamini, Zodwa; Hull, Rodney; Makhafola, Tshepiso Jan; Mbele, Mzwandile (Dove Medical Press, 2019)
    Obesity is the result of genetics which predisposes an individual to obesity and environmental factors, resulting in excessive weight gain. A well-established linear relationship exists between hypertension and obesity. ...