Research Articles (Radiography)

Permanent URI for this collectionhttp://hdl.handle.net/2263/1839

For inquiries regarding this collection or items in the collection, please contact : Susan Scheepers
Tel.: +27 12 354 1433

Browse

Now showing 1 - 20 of 54

Multi-target inhibitor CUDC-101 impairs DNA damage repair and enhances radiation response in triple-negative breast cell line
(MDPI, 2024-11-01) Seane, Elsie Neo; Nair, Shankari; Vandevoorde, Charlot; Bisio, Alessandra; Joubert, Anna Margaretha; annie.joubert@up.ac.za
BACKGROUND : Since the discovery that Histone deacetylase inhibitors (HDCAi) could enhance radiation response, a number of HDACi, mainly pan-HDAC inhibitors, have been studied either as monotherapy or in combination with X-ray irradiation or chemotherapeutic drugs in the management of breast cancer. However, studies on the combination of HDACi and proton radiation remain limited. CUDC-101 is a multitarget inhibitor of Histone deacetylases (HDACs), epidermal growth factor receptor (EGFR), and human epidermal growth factor receptor 2 (HER-2). In this paper, the effectiveness of CUDC-101 in enhancing radiation response to both proton and X-ray irradiation was studied. METHODS : MCF-7, MDA-MB-231, and MCF-10A cell lines were pre-treated with CUDC- 101 and exposed to 148 MeV protons, and X-rays were used as reference radiation. Colony survival, γ-H2AX foci, apoptosis, and cell cycle analysis assays were performed. RESULTS : γ-H2AX foci assays showed increased sensitivity to CUDC-101 in the MDA-MB-231 cell line compared to the MCF-7 cell line. In both cell lines, induction of apoptosis was enhanced in CUDC-101 pre-treated cells compared to radiation (protons or X-rays) alone. Increased apoptosis was also noted in CUDC-101 pre-treated cells in the MCF-10A cell line. Cell cycle analysis showed increased G2/M arrest by CUDC-101 mono-treatment as well as combination of CUDC-101 and X-ray irradiation in the MDA-MB-231 cell line. CONCLUSIONS : CUDC-101 effectively enhances response to both proton and X-ray irradiation, in the triple-negative MDA-MB-231 cell line. This enhancement was most notable when CUDC-101 was combined with proton irradiation. This study highlights that CUDC-101 holds potential in the management of triple-negative breast cancer as monotherapy or in combination with protons or X-ray irradiation.
Mechanistic sequence of histone deacetylase inhibitors and radiation treatment : an overview
(MDPI, 2024-05-08) Seane, Elsie Neo; Nair, Shankari; Vandevoorde, Charlot; Joubert, Anna Margaretha; annie.joubert@up.ac.za
Histone deacetylases inhibitors (HDACis) have shown promising therapeutic outcomes in haematological malignancies such as leukaemia, multiple myeloma, and lymphoma, with disappointing results in solid tumours when used as monotherapy. As a result, combination therapies either with radiation or other deoxyribonucleic acid (DNA) damaging agents have been suggested as ideal strategy to improve their efficacy in solid tumours. Numerous in vitro and in vivo studies have demonstrated that HDACis can sensitise malignant cells to both electromagnetic and particle types of radiation by inhibiting DNA damage repair. Although the radiosensitising ability of HDACis has been reported as early as the 1990s, the mechanisms of radiosensitisation are yet to be fully understood. This review brings forth the various protocols used to sequence the administration of radiation and HDACi treatments in the different studies. The possible contribution of these various protocols to the ambiguity that surrounds the mechanisms of radiosensitisation is also highlighted.
A reflective thematic analysis into the perceptions of pregnant radiographers regarding the usefulness of the Pregidose mobile app to enhance fetal dosimetry and well-being : qualitative exploration
(JMIR Publications, 2024) Essop, Hafsa; Kekana, R.M. (Mable); Brosens, Jacques; Smuts, Hanlie
BACKGROUND : Pregnancy apps are widely used by pregnant women, who benefit from self-tracking features to support their health goals. Pregnant radiographers are considered a high-risk group of health workers practicing in ionizing radiation environments. Radiation exposure above threshold limits can cause harmful genetic effects on a fetus. Accordingly, pregnant radiographers are required to wear special fetal dosimeters, which provide real-time readings of radiation dose exposure to the fetus. Pregnant radiographers have the responsibility to self-track their fetal doses to ensure that the threshold limit of 1 mGy is not exceeded. The traditional method used to track doses includes a written log of doses in a notebook. Thus, PregiDose, a unique offering in the context of pregnancy apps, was developed to enhance fetal dose tracking and monitoring using technological methods. OBJECTIVE : This study aims to describe the users’ perceptions of the app’s usefulness using PregiDose in a natural setting. METHODS : The overarching framework adopted for the study was a design science research (DSR) methodology encompassing five steps, namely (1) problem awareness, (2) suggestion, (3) development, (4) evaluation, and (5) conclusion. This paper presents the evaluation step of DSR. DSR step 4 included a qualitative approach to explore users’ perceptions regarding the app. Data were collected using a semistructured interview guide. Open-ended questions were guided by the app’s core features, namely dose tracking, education, and wellness. In total, 17 pregnant radiographers in South Africa enrolled to use the app, 9 (53%) engaged with the app, and 4 (24%) agreed to participate in the feedback interviews. The data were collected from October 2023 to March 2024 and analyzed using a reflective thematic data analysis method. RESULTS : Three overarching themes emerged from the data, namely (1) usefulness of PregiDose, (2) barriers to PregiDose adoption and use, and (3) recommendations for the advancement of PregiDose. Users labeled the app’s usefulness as positive and perceived it as a modern approach to traditional dose-tracking methods. They perceived the graph output of the dose-tracking feature to be useful for viewing their accumulative doses. They did not fully engage with the journaling feature, indicating that it was a personal preference and not a practice they would usually engage in. Physiological barriers, such as fatigue and “pregnancy brain,” were contributors to decreased engagement. Finally, because of the demanding workload and fast-paced nature of the radiography department, users recommended the automation of fetal dosimetry through the Internet of Things. CONCLUSIONS : PregiDose is an occupational health and safety mobile app developed for pregnant radiographers through a DSR approach. The app offers a modern method of dose tracking consistent with technological advancements in the context of self-tracking. However, future implementation would require using Internet of Things to make fetal dose tracking more effective.
Ionising radiation exposure-induced regulation of selected biomarkers and their impact in cancer and treatment
(Frontiers Media, 2024-10) Mzizi, Yonwaba; Mbambara, Saidon; Moetlhoa, Boitumelo; Mahapane, Johncy; Mdanda, Sipho; Sathekge, Mike Machaba; Kgatle, Mankgopo
Ionising radiation (IR) is a form of energy that travels as electromagnetic waves or particles. While it is vital in medical and occupational health settings, IR can also damage DNA, leading to mutations, chromosomal aberrations, and transcriptional changes that disrupt the functions of certain cell regulators, genes, and transcription factors. These disruptions can alter functions critical for cancer development, progression, and treatment response. Additionally, IR can affect various cellular proteins and their regulators within different cell signalling pathways, resulting in physiological changes that may promote cancer development, progression, and resistance to treatment. Understanding these impacts is crucial for developing strategies to mitigate the harmful effects of IR exposure and improve cancer treatment outcomes. This review focuses on specific genes and protein biomarkers regulated in response to chronic IR exposure, and how their regulation impacts disease onset, progression, and treatment response.
Summiting success : navigating the educational landscape
(Elsevier, 2024-12) Kruger, Zanelle; z.kruger@up.ac.za
Radiography education is ever-changing. The educational landscape is marked by constant technological shifts and formidable challenges, for example hybrid learning platforms and integration of artificial intelligence. The demand for adaptable clinical and academic professionals has never been more pressing. In a field where, traditional teaching methods fall short, it's important for students to be critical thinkers who can seamlessly navigate the rapidly changing terrain is paramount. Welcome to the forefront of radiography education, where innovation meets necessity, and where I've crafted a metaphorical compass to guide academics and students through this dynamic educational landscape – my educational practice metaphor.
Co-designing of a prototype mobile application for fetal radiation dose monitoring among pregnant radiographers using a design thinking approach
(Sage, 2024-10) Essop, Hafsa; Kekana, Ramadimetja; Smuts, Hanlie; hafsa.essop@up.ac.za
This study aimed to develop a prototype mobile application to enhance fetal dosimetry among pregnant radiographers in #### through a design thinking approach. Eleven participants were recruited to engage in a participatory design workshop, which encompassed five stages: Empathise, Ideate, Define, Prototype and Test. The participants were divided into two teams. Qualitative datasets from the workshop included field notes and FIGMA screens. The data were analysed through thematic analysis, from which three major themes emerged: (1) Unsafe working environments for pregnant radiographers, (2) The need for enhanced fetal radiation dose monitoring by pregnant radiographers as an occupational health and safety requirement, and (3) Co-designing of the prototype mobile application, PregiDose. The participants contributed towards a prototype mobile application which addressed challenges experienced in the real-life setting. Hence, the prototype can be used as an effective framework by which to guide the development of the final artefact.
Staff perspectives on transformational needs at a South African higher education institution
(Wiley, 2024-10) Magida, Nontembiso; Yazbek, Mariatha; Thambura, Julius Muchui; nontembiso.magida@up.ac.za
Transformation reflects the government's engagement and policies in restructuring higher education to cultivate the country's communal economy. Higher education is challenged in providing tertiary education to students from diverse environments, and staff transformation is needed. This cross-sectional study establishes the staff's perception of transformation in the School of Healthcare Sciences of a selected South African university. Staff were purposively sampled and were surveyed using an electronic questionnaire. The survey included aspects of equity, transformation, management, recognition, the social environment, the physical environment and general satisfaction. Demographic variables, including the perspective on transformation in the institution, the student body and transformation management, were descriptively analysed. Most staff members perceived the university as committed to transformation despite racial tensions and past injustices. Over two-thirds of the staff support the university's goal of increasing a diverse student body. Additionally, the management is comfortable with diversity and demonstrates equity for all. The implementation of transformation was actively considered and aligned with policies.
Fetal dosimeter access, usage, and training among pregnant radiographers in South Africa
(Elsevier, 2023-10) Essop, Hafsa; Kekana, Mable; Smuts, Hanlie; Masenge, Andries; hafsa.essop@up.ac.za
BACKGROUND : Pregnant radiographers require more stringent occupational safety monitoring through fetal dosimetry because of the sensitivity of their fetuses’ cells to radiation. This study aims to describe fetal dosimetry among pregnant radiographers as regards access, usage, and training. METHODS : Quantitative data were collected using an electronic national survey. The study collected 89 responses from pregnant and previously pregnant radiographers in South Africa between January 2021 and April 2021. FINDINGS : The responses revealed that 53.9% (n ¼ 48) of participants had never been issued with a fetal dosimeter. This situation was mostly attributed to the employer and financial constraints (n ¼ 29). Of those with access to fetal dosimeters, 46.1% (n ¼ 41), only 56% (n ¼ 28) indicated that they always wore it. An alarming 52% (n ¼ 26) never consistently recorded fetal doses. DISCUSSION : Most pregnant South African radiographers do not have access to fetal dosimeters.Many of them remain noncompliant, which might be attributed to a lack of training and knowledge about the device.
July 2021 civil unrest : South African diagnostic radiography students’ experiences
(AOSIS, 2023-08-31) Naidoo, Kathleen; Lewis, Shantel; Essop, Hafsa; Koch, Gerhardus G.V.; Khoza, Thandokuhle E.; Badriparsad, Nicole R.; hafsa.essop@up.ac.za
BACKGROUND : South Africa (SA), in 2021, experienced a wave of civil unrest following political events that led to mass looting and the destruction of property. Civil unrests, among other disruptions, have been seen to cause ripple effects on healthcare education, particularly for radiography students who undergo work integrated learning within hospitals and universities, even during these times of unrest. AIM : This study aimed to explore and describe the undergraduate diagnostic radiography students’ experience of the civil unrest that occurred in SA in 2021. SETTING : The study was conducted across five universities in South Africa, offering the diagnostic radiography programme. METHODS : A qualitative, interpretive phenomenological design was employed as it enabled the researchers to facilitate focus group interviews to gain insight into the lived experiences of the students during this time. RESULTS : Four themes emerged from the study data, namely: (1) Negative effects on students’ emotional and psychological well-being, (2) Academic and clinical support mechanisms during disruptions, (3) The influence of disruptions on clinical training, (4) Recommendations to support students for future disruptions. CONCLUSION : The participants from this study described the negative effects that the civil unrest had on their emotional and mental well-being. There is a need for increased support mechanisms during times of disruptions from universities across South Africa. CONTRIBUTION : The findings highlight the ripple effects that disruptions, such as civil unrests, have on radiography students. This can assist universities to relook at their institutional support structures, in order to enhance the current support given to students across universities in times of disruptions.
Barriers and enablers for implementation of digital-linked diagnostics models at point-of-care in South Africa : stakeholder engagement
(BMC, 2024-02) Moetlhoa, Boitumelo; Nxele, Siphesihle Robin; Maluleke, Kuhlula; Mathebula, Evans Mantiri; Marange, Musa; Chilufya, Maureen; Dzinamarira, Tafadzwa; Duah, Evans; Dzobo, Matthias; Kekana, Mable; Jaya, Ziningi Nobuhle; Thabane, Lehana; Dlangalala, Thobeka Nomzamo; Nyasulu, Peter S.; Hlongwana, Khumbulani; Dlungwane, Thembelihle; Kgatle, Mankgopo; Gxekea, Nobuhle; Mashamba‑Thompson, Tivani Phosa; u22029992@tuks.co.za
The integration of digital technologies holds significant promise in enhancing accessibility to disease diagnosis and treatment at point-of-care (POC) settings. Effective implementation of such interventions necessitates comprehensive stakeholder engagements. This study presents the outcomes of a workshop conducted with key stakeholders, aiming to discern barriers and enablers in implementing digital-connected POC diagnostic models in South Africa. The workshop, a component of the 2022 REASSURED Diagnostics symposium, employed the nominal group technique (NGT) and comprised two phases: Phase 1 focused on identifying barriers, while Phase 2 centered on enablers for the implementation of digital-linked POC diagnostic models. Stakeholders identified limited connectivity, restricted offline functionality, and challenges related to load shedding or rolling electricity blackouts as primary barriers. Conversely, ease of use, subsidies provided by the National Health Insurance, and 24-h assistance emerged as crucial enablers for the implementation of digital-linked POC diagnostic models. The NGT workshop proved to be an effective platform for elucidating key barriers and enablers in implementing digital-linked POC diagnostic models. Subsequent research endeavors should concentrate on identifying optimal strategies for implementing these advanced diagnostic models in underserved populations.
Checklists for interpreting chest radiographs : a scoping review protocol
(BMC, 2023-08-30) Sethole, Khethiwe Margaret; Mshunqane, Nombeko; Kekana, Mable; margaret.sethole@up.ac.za
INTRODUCTION : What is known about checklists for interpreting chest radiographs? The question will guide the development of the inclusion criteria for the scoping review. Breaking down the scoping review question will allow the evaluation of inclusion and exclusion criteria for the protocol. The eligibility of the proposed research question will be assessed using the Population or Participants, Concept and Context (PCC) framework. BACKGROUND : X-ray reporting can be standardised using checklists. Checklists may reduce the time needed to produce a comprehensive X-ray report and improve the quality and consistency of detecting abnormalities on chest radiographs. This scoping review aims to map the available literature on what is known about checklists for interpreting chest radiographs. METHODS : We will follow the methodological framework for scoping reviews originally described by Arksey and O’Malley. The scoping review will include articles that describe checklists for reducing diagnostic errors, checklists for analysing chest radiographs, checklists for identifying abnormalities on chest radiographs and checklists for reporting chest radiographs in all settings. Search terms are chest radiographs, checklists, and chest X-rays. We will search for peer-reviewed articles and grey literature including dissertations and theses. We will search online databases including Ovid Medline and Ebscohost, to identify articles published in English from 1994 to 2022. The searched articles will undergo two levels of screening, first the title and abstract screening, then a full-text screening by two reviewers. Data from the selected articles will be extracted, using a tested extraction form and charted using the Joanna Briggs Institute guidelines. RESULTS : The results will be collated, summarised and discussed including any limitations of the included articles. The articles will be summarised in a table, as well as narratively. The distribution of studies will be summarised quantitatively and the numerical analysis will provide an overview and identify knowledge gaps. Content analysis will map different checklists available for chest interpretation. DISCUSSION : The results of the scoping review will be used to develop a checklist that will be used by medical doctors in collaboration with radiographers working in settings where there are no radiologists on-site, for interpreting chest radiographs. SYSTEMATIC REVIEW REGISTRATION : Scoping review protocol registered with Open Science Framework on 27 July 2022. Registration https:// doi. org/ 10. 17605/ OSF. IO/ JS5PQ.
Checklists for interpreting chest radiographs : a scoping review
(Elsevier, 2023-12) Sethole, Khethiwe Margaret; Mshunqane, Nombeko; Maluleke, Kuhlula; Kekana, Mable; Mbonambi, Linda; margaret.sethole@up.ac.za
INTRODUCTION : Checklists reduce time to comprehensive radiographic reports, improve quality and consistency of abnormality detection on chest radiographs. AIM : The aim of this review was to examine and survey the scope of published research on checklists for the interpretation of chest radiographs. METHOD : We conducted a search of CINAHL, Scopus, Medline Ovid, Web of Science, ProQuest, and gray literature using search terms: chest radiographs, checklist, and image interpretation. Data were extracted from 16 articles. Data was analyzed numerically and thematically. RESULTS : The selected studies were conducted in the United States (37.5%), the United Kingdom (25%), Australia (12%), South Africa (12%), Turkey (6%), and Israel (6%). The codes were grouped into five categories related to the use of checklists, in chest interpretation. CONCLUSION : In the selected studies, reports showed that there was no checklist for chest interpretation in South Africa and no evidence supporting checklists as an interprofessional communication tool for chest interpretation. The authors of this study recommended a chest interpretation checklist should be developed for use by health care professionals practicing in resource-limited settings where radiologists are not on site.
An investigation into the use of full-body low dose x-rays imaging system in South Africa : radiographer’s perspective
(Elsevier, 2023-09) Thambura, Julius Muchui
INTRODUCTION : A low dose x-rays alias Lodox© statscan was originally developed in South Africa to detect smuggled diamonds in the mines. Later, hospital trauma units began to use it as a screening tool for gross pathology on trauma patients. This imaging system became popular because of its use of low radiation doses and its ability to perform anterior posterior (head to toe image) image in under 13 seconds. Anecdotal evidence confirms that patients were referred for additional regional images on conventional x-ray systems after Lodox imaging. Thus, patients were subjected to additional ionising radiation, long waiting times as well as additional charges for secondary radiological examinations. OBJECTIVE : This research aimed at investigating the extent to which Lodox was used in trauma units (n=28) in South Africa. METHOD : In this descriptive cross-sectional research. researcher invited one radiographer from each of the 28 hospitals in South Africa that were using Lodox. RESULTS : Out of twenty radiographers who responded, it was found that most hospitals were referring patients for additional conventional x-ray images (Figure 1); for example, for chest x-rays. This was done despite the patient having undergone radiological procedures and examinations by the Lodox imaging system that was similar to those performed by conventional x-ray systems. CONCLUSION : Lodox was used for a successful diagnosis Thus, researcher recommends an imaging protocol for Lodox to be developed for guiding the referral of patients after the Lodox scanning has been performed.
A radiological assessment of the prevalence of osteoporosis in male patients seen in a South African Hospital : a retrospective analysis
(Hindawi, 2022-05-04) Siwela, Lebohang; Khan, Nausheen; Mudau, Adziambei; u27027211@tuks.co.za
Developing countries are predicted to bear the burden of osteoporosis in the coming decades. The prevalence of osteoporosis in South African men is unknown, but is thought to be rare. Opportunistic screening for osteoporosis can be performed using quantitative computed tomography (CT) obtained for various clinical indications. We assessed the frequency of osteoporosis in male patients using quantitative computed tomography (CT) obtained for various clinical indications. Data were collected from abdominal and spinal CT scans performed at the radiology department of a provincial tertiary hospital between January 2019 and January 2021. The CT examinations were derived from 507 male patients (mean age, 45±15 years; 83% Black, 0.8% Coloured, 4.1% Indian and 11.2% White). In the CT scans, the region of interest was placed manually at the axial cross-sections of L1 and L3 vertebrae. Using densitometry, we calculated average bone mass density and T and Z scores. We diagnosed osteoporosis in 18.5% (n 94) of our patients. Only 7.9% of patients younger than 50 had osteoporosis, while 35.9% of patients older than 50 years showed signs of osteoporosis. Osteoporosis was more common amongst White male patients (45.6%) and least common in Black male patients (14.4%). Indian patients had the highest prevalence of osteopenia (42.9%). We successfully used CT scans, obtained for various conditions, to identify large numbers of patients with low bone mineral density (BMD). +e prevalence of osteoporosis in this sample is similar to rates reported elsewhere in Africa. Asymptomatic patients at risk of developing insufficiency fractures can be diagnosed and managed early using CT scans, thus preventing unnecessary admissions and reducing osteoporosis-related morbidity and mortality.
Perceptions of radiographers regarding establishing a self-regulatory body for radiation safety in Eswatini
(Elsevier, 2021-05) Dlamini, Lungile; Kekana, R.M. (Mable)
INTRODUCTION : Eswatini remains one of the countries in Southern Africa without a regulating authority for radiation safety in the radiography departments. Quality control (QC) tests and radiation protection practices are unmonitored. This study sought to explore radiographers’ perceptions regarding establishing a self-regulatory body that will formulate, implement and monitor compliance of standardised guidelines for radiation safety. METHODS : A qualitative, exploratory and descriptive research approach was undertaken. Radiographers currently registered and practicing in Eswatini were purposively selected and invited to participate. Data was collected using semi-structured interviews. Audiotapes and field notes were used. Audio taped interviews were transcribed verbatim and then analyzed using qualitative content analysis. RESULTS : Six themes emerged from the analysis of data, namely; a) awareness of the need for QC tests, b) radiation protection and safety in the radiography departments, c) radiographers’ responsibility towards radiation protection, d) education and training in radiation safety for radiographers and other stakeholders, e) support from governmental and management structures and f) the need for the self-regulatory body in the radiography departments. CONCLUSION : The study demonstrated that there is awareness among radiographers in Eswatini that radiation safety practices are necessary in the radiography departments. Continuous education and training were deemed as imperative to improve radiation safety in the radiography departments. There is also support for the idea of establishing the self-regulatory body. IMPLICATIONS FOR PRACTICE : The need for monitoring structures in order to ensure radiation safety in the radiography departments is highlighted in this study. Government officials and hospital management are crucial in ensuring radiation safety in radiography departments.
Magnetic resonance imaging features of dermatofibrosarcoma protuberans : what the surgeon should know : a case series
(South African Medical Association, 2021-06) Sitela, V.; Khan, Nausheen; nausheen.khan@up.ac.za
Dermatofibrosarcoma protuberans (DFSP) is a rare, slow-growing, spindle cell neoplasm with low to intermediate grade malignant potential, commonly found in young and middle-aged adults, more in males than females. DFSP mostly originates in the dermis; rarely, it may be located in the deeper tissues without dermal involvement. Typically, DFSP appears as a multinodular mass, which then spreads into the subcutaneous tissues and muscle; it rarely dedifferentiates to high-grade fibrosarcoma, and more rarely, it may metastasise. We describe magnetic resonance imaging (MRI) features in three female patients with histologically proven DFSP and review the literature.
Diagnostic radiographers’ experiences when interacting with the custodians of paediatric patients presenting for general radiographic imaging
(Elsevier, 2021-11) Ketema, S.F.; Kekana, R.M. (Mable); Essop, Hafsa; Msonza, H.W.
INTRODUCTION : Radiographic imaging of children presents several complexities, one of which includes their reliance on an adult to take care of them. Literature reports on investigations that focused on interactions of healthcare professionals with children and their parents or guardians in the healthcare setting, but little is known about radiographers’ interactions with different custodians of paediatric patients. This study sought to explore and describe the experiences of radiographers with the different custodians of paediatric patients and assess how these custodians contribute to the outcomes of radiographic examinations. METHODS : A qualitative, exploratory descriptive design was undertaken. Purposive sampling was used to select 25 radiographers from four health institutions in the Tshwane region of South Africa. Semi-structured interviews, audiotapes and field notes were used to collect data. Qualitative content analysis was used to analyse the transcribed data. RESULTS : The following three themes emerged, namely; a) communication with different custodians, b) a radiographer's role in suspected physical abuse (SPA) and c) radiographers' responsibilities and associated radiation concerns. CONCLUSION : Radiographers experienced different communication and interaction challenges in the imaging department with various custodians of paediatric patients. These impacted service deliveries. The paediatric patient's reaction in the imaging room might further affect the interaction between the radiographer and the custodian. IMPLICATIONS FOR PRACTICE : There is a need for further studies that explore the concerns that radiographers have regarding their limited role in SPA. In addition, the study also adds to increasing awareness of both health professionals and the general public on radiation protection and safety.
Hematologic toxicity profile and efficacy of [225Ac]Ac-PSMA-617 α-radioligand therapy of patients with extensive skeletal metastases of castration-resistant prostate cancer
(Springer, 2022-08) Lawal, Ismaheel Opeyemi; Morgenstern, Alfred; Vorster, Mariza; Knoesen, Otto; Mahapane, Johncy; Hlongwa, Khanyisile N.; Maserumule, Letjie C.; Ndlovu, Honest; Reed, Janet D.; Popoola, Gbenga O.; Mokoala, Kgomotso M.G.; Mdlophane, A.H.; Bruchertseifer, Frank; Sathekge, Mike Machaba; mike.sathekge@up.ac.za
Please read abstract in the article.
[68 Ga]Ga-FAPI versus [18F]F-FDG in malignant melanoma: complementary or counterpoint?
(Springer, 2022-06) Mokoala, Kgomotso M.G.; Emil, Novruzov; Lawal, Ismaheel Opeyemi; Antke, Christina; Giesel, Frederik L.; Sathekge, Mike Machaba; mike.sathekge@up.ac.za
No abstract available.
An overview of the developments and potential applications of Ga-68-labelled PET/CT hypoxia imaging
(Springer, 2021-02) Bresser, Philppa Lynn; Vorster, Mariza; Sathekge, Mike Machaba; pippa.bresser@up.ac.za
Non-invasive imaging of hypoxia plays a role in monitoring the body’s adaptive response or the development of pathology under hypoxic conditions. Various techniques to image hypoxia have been investigated with a shift towards the use of molecular imaging using PET/CT. The role of hypoxia-specific radiopharmaceuticals such as radiolabelled nitroimidazoles is well documented particularly in the oncologic setting. With the increasing utilisation of in-house labelling with a PET benchtop generator, such as the 68Ge/68Ga generator, the use of 68Ga-labelled hypoxic radiopharmaceuticals in the clinical setting is developing. Since hypoxia plays a role in various pathologic states including infectious disease such as TB, there is a need to explore the potential application of 68Ga-labelled hypoxia seeking radiopharmaceuticals beyond oncology. The purpose of this review is to describe the developments of 68Ga-labelled hypoxic radiopharmaceuticals including the various chelators that have been investigated. Further, the role of hypoxia imaging in various pathologies is discussed with particular emphasis on the potential clinical applications of hypoxia PET/CT in TB.

Browse

Recent Submissions