Comparison of structures and cytotoxicity of mupirocin and batumin against melanoma and several other cancer cell lines

Reva, Oleg N.; Rademan, Sunelle; Visagie, M.H. (Michelle Helen); Lebelo, M.T. (Maphuti); Gwangwa, Mokgadi Violet; Klochko, Vitalii V.; Joubert, Anna Margaretha; Lall, Namrita

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Comparison of structures and cytotoxicity of mupirocin and batumin against melanoma and several other cancer cell lines

Reva, Oleg N.; Rademan, Sunelle; Visagie, M.H. (Michelle Helen); Lebelo, M.T. (Maphuti); Gwangwa, Mokgadi Violet; Klochko, Vitalii V.; Joubert, Anna Margaretha; Lall, Namrita

URI: http://hdl.handle.net/2263/70250

Date: 2019

Abstract:

AIM : To determine the computer-predicted anticancer activity of mupirocin and to compare its activities with those determined for another polyene antibiotic, batumin. MATERIALS AND METHODS : Molecular docking, cytotoxicity assays, cell microscopy and cell cycle progression were studied in cancer and nontumorigenic cell lines. RESULTS AND CONCLUSION : Cytotoxicity of mupirocin against several cancerous cell lines was detected with the highest one (IC50 = 5.4 μg/ml) against melanoma cell line. The profile of cytotoxicity of mupirocin was similar to that reported for batumin. Nevertheless, the morphology of cells treated with these antibiotics and alterations in cell cycle progression suggested possible dissimilarity in their mechanisms of action. Selective cytotoxicity of mupirocin against melanoma cells potentiates further studies to discover nontoxic drugs for melanoma prevention.

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