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Browsing Natural and Agricultural Sciences by Subject "(Bis)urea"

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Discovery of novel alkylated (bis)urea and (bis)thiourea polyamine analogues with potent antimalarial activities

Verlinden, Bianca K.; Niemand, Jandeli; Snyman, Janette; Sharma, Shirv K.; Beattie, Ross J.; Woster, Partick M.; Birkholtz, Lyn-Marie (American Chemical Society, 2011-10)

A series of alkylated (bis)urea and (bis)thiourea polyamine analogues were synthesized and screened for antimalarial activity against chloroquine-sensitive and -resistant strains of Plasmodium falciparum in vitro. All ...
Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites

Verlinden, Bianca K.; De Beer, Marna; Pachaiyappan, Boobalan; Besaans, Ethan Wade; Anday, Warren A.; Reader, Janette; Niemand, Jandeli; Van Biljon, Riette Andele; Guy, Kiplin; Egan, Timothy; Woster, Patrick M.; Birkholtz, Lyn-Marie (Elsevier, 2015-08)

A new series of potent potent aryl/alkylated (bis)urea- and (bis)thiourea polyamine analogues were synthesized and evaluated in vitro for their antiplasmodial activity. Altering the carbon backbone and terminal substituents ...

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Browsing Natural and Agricultural Sciences by Subject "(Bis)urea"

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