Browsing Theses and Dissertations (University of Pretoria) by Subject "X-ray crystallography"

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Biochemical and structural characterization of novel drug targets regulating polyamine biosynthesis in the human malaria parasite, Plasmodium falciparum

Williams, Marni (University of Pretoria, 2011)

Malaria is prevalent in over 100 countries which is populated by half of the world’s population and culminates in approximately one million deaths per annum, 85% of which occurs in sub-Saharan Africa. The combined resistance ...
Structural and inhibition studies of thiamine monosphosphate kinase from Mycobacterium tuberculosis

Dlamini, Lenye Sebenzile (University of Pretoria, 2020)

Vitamin B1 is an indispensable co-factor for various enzymes inter alia in the Krebs cycle, pentose phosphate pathway, nucleotide and amino acid synthesis. Due to its importance in metabolism, proteins involved in the ...

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