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Browsing Biochemistry by Type "Postprint Article"
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Harmse, Rozanne; Coertzen, Dina; Wong, Ho Ning; Smit, Frans J.; Van der Watt, Mariette Elizabeth; Reader, Janette; Nondaba, Sindisiwe; Birkholtz, Lyn-Marie; Haynes, Richard K.; N'Da, David D.
(Wiley, 2017-12)
Dihydroartemisinin (DHA), either used in its own right or as the active drug generated in vivo from the other artemisinins in current clinical use—artemether and artesunate—induces quiescence in ring‐stage parasites of ...
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Wall, Gayle V.; Wright, Isabella M.; Barnardo, Carin; Erasmus, Baltus J.; Van Staden, Vida; Potgieter, A. Christiaan
(Elsevier, 2021-06)
African horse sickness virus (AHSV) non-structural protein NS4 is a nucleocytoplasmic protein that is expressed in the heart, lung, and spleen of infected horses, binds dsDNA, and colocalizes with promyelocytic leukemia ...
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Krivak-Tetley, Flora E.; Lantschner, M. Victoria; Lombardero, Maria J.; Garnas, Jeffrey R.; Hurley, Brett Phillip; Villacide, Jose M.; Slippers, Bernard; Corley, Juan C.; Liebhold, Andrew M.; Ayres, Matthew P.
(Elsevier, 2021-03)
Invasive insects and pathogens are prominent tree mortality agents in forests around the world, and the magnitude of their impacts is increasing. Comparative studies across multiple populations can be helpful for the ...
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Sayari, Mohammad; Van der Nest, Magrieta Aletta; Steenkamp, Emma Theodora; Adegeye, O.O.; Marincowitz, Seonju; Wingfield, Brenda D.
(Elsevier, 2019-09)
Functional association between genomic loci and specific biological traits remains lacking in many fungi, including the African tree pathogen Ceratocystis albifundus. This is mainly because of the absence of suitable ...
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Van der Westhuizen, Magdalien; Steenkamp, Lucia; Steenkamp, Paul; Apostolides, Zeno
(Taylor & Francis, 2016-03)
The principal pigments present in black tea, theaflavins (TF), have been indicated to be of potential clinical significance in various fields of research which has been hampered by the very low levels of TFs from black tea ...
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Bekker, Shani; Burger, Pieter Buys; Van Staden, Vida
(Elsevier, 2017-03)
VP7 is the major core protein of orbiviruses and is essential for virion assembly. African horse sickness virus (AHSV) VP7 self-assembles into highly insoluble crystalline particles – an attribute that may be related to ...
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Niemand, Jandeli; Burger, Pieter Buys; Verlinden, Bianca K.; Reader, Janette; Joubert, Annie M.; Kaiser, Annette; Louw, Abraham Izak; Kirk, Kiaran; Phanstiel IV, Otto; Birkholtz, Lyn-Marie
(American Society for Microbiology, 2013-06)
Anthracene-polyamine conjugates inhibit the in vitro proliferation of the
intraerythrocytic human malaria parasite, Plasmodium falciparum, with IC50 values in
the nM-μM range. The compounds are taken up into the ...
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Miller, Susan M.; Moeller, Carl-Heinz; Harper, Cindy Kim; Bloomer, Paulette
(Springer, 2020-08)
Hybridisation caused by anthropogenic movements of animals is a conservation concern. Black-faced impala (Aepyceros melampus petersi) are endemic to north-western Namibia and south-western Angola and are geographically ...
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Malan, Melissa; Serem, June Cheptoo; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques
(Wiley, 2016-01)
Antimicrobial peptides (AMPs) are small, cationic peptides that possess a large spectrum of bioactivities, including antimicrobial, anti-inflammatory and antioxidant activities. Several AMPs are known to inhibit ...
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Pereira, Andreia S.P.; Bester, Megan Jean; Soundy, Puffy; Apostolides, Zeno
(Taylor and Francis, 2016-09)
CONTEXT : Pelargonium sidoides DC (Geraniaceae) is an important medicinal plant indigenous to South Africa and Lesotho. Previous studies have shown root extracts rich in polyphenolic compounds with antibacterial, antiviral ...
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Baloyi, Itumeleng Tsebang; Cosa, Sekelwa; Combrinck, Sandra; Leonard, Carmen M.; Viljoen, Alvaro M.
(Elsevier, 2019-05)
Urinary tract infections (UTIs) primarily affect women and have increasingly become a serious health problem globally. These infections are largely attributed to the quorum sensing (QS)-dependent ability of pathogens to ...
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Du Rand, Esther Elizabeth; Stutzer, Christian; Human, Hannelie; Pirk, Christian Walter Werner; Nicolson, Sue W.
(Springer, 2020-02)
Nutritional stress due to habitat transformation and loss is one of several factors contributing to current declines in global bee populations. Bees obtain protein from pollen, which in honeybees is consumed and digested ...
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Dziwornu, Godwin Akpeko; Coertzen, Dina; Leshabane, Meta Kgaogelo; Korkor, Constance M.; Cloete, Cleavon K.; Njoroge, Mathew; Gibhard, Liezl; Lawrence, Nina; Reader, Janette; Van der Watt, Mariette Elizabeth; Wittlin, Sergio; Birkholtz, Lyn-Marie; Chibale, Kelly
(American Chemical Society, 2021-04)
A novel series of antimalarial benzimidazole derivatives incorporating phenolic Mannich base side chains at the C2 position, which possess dual asexual blood and sexual stage activities, is presented. Structure–activity ...
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Ahenkorah, Stephen; Coertzen, Dina; Tong, Jie Xin; Fridianto, Kevin; Wittlin, Sergio; Birkholtz, Lyn-Marie; Tan, Kevin S.W.; Lam, Yulin; Go, Mei-Lin; Haynes, Richard K.
(American Chemical Society, 2020)
Please read abstract in the article.
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Van Breda, Shane Vontelin; Buys, Antoinette; Apostolides, Zeno; Nardell, Edward Anthony; Stoltz, Anton Carel
(Elsevier, 2015-07)
Polymyxins have previously been described to have activity against M. tuberculosis
(MTB), but further research was abandoned due to systemic toxicity concerns to
achieve the required MIC. Colistin methanesulfonate (CMS), ...
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Pardau, Madelein D.; Pereira, Andreia S.P.; Apostolides, Zeno; Serem, June Cheptoo; Bester, Megan Jean
(Royal Society of Chemistry, 2017-12)
Ilex guayusa tea preparations are now commercially available as Runa tea. Little is known regarding the antioxidant and anti-inflammatory bioactivities of this tea. The I. guayusa teas had a total polyphenolic content ...
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Archer, C. Ruth; Kohler, Angela; Pirk, Christian Walter Werner; Oosthuizen, Vinette; Apostolides, Zeno; Nicolson, Sue W.
(Elsevier, 2014-12)
Over-consuming amino acids is associated with reduced survival in many species, including honeybees.
The mechanisms responsible for this are unclear but one possibility is that excessive intake of amino
acids increases ...
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Coertzen, Dina; Reader, Janette; Van der Watt, Mariette Elizabeth; Nondaba, Sindisiwe; Gibhard, Liezl; Wiesner, Lubbe; Smith, Peter; D'Alessandro, Sarah; Taramelli, Donatella; Wong, Ho Ning; Du Preez, Jan L.; Wu, Ronald Wai Keung; Birkholtz, Lyn-Marie; Haynes, Richard K.
(American Society for Microbiology, 2018-08)
The emergence of resistance towards artemisinin combination therapies (ACTs) by the malaria parasite Plasmodium falciparum has the potential to severely compromise malaria control. Therefore, development of new artemisinins ...
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Fang, Zhuo; Van der Merwe, Ruben Gerhard; Warren, Robin M.; Schubert, Wolf-Dieter; Gey van Pittius, Nicolaas C.
(Elsevier, 2015-03)
Tuberculosis threatens human health nowhere more than in developing countries with large malnourished
and/or immune-compromised (e.g. HIV infected) populations. The etiological agent, Mycobacterium
tuberculosis (Mtb), ...
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Malebe, Pelly Masixolise; Mphangwe, N.I.K.; Myburg, Alexander Andrew; Apostolides, Zeno
(Springer, 2019-06)
Tea is the world’s most consumed beverage, next to water. This makes it an economically important crop. However, the genetic relationship between the cultivars at the Tea Research Foundation of Central Africa (TRFCA) have ...