A biomimetic approach to the synthesis of a mycolic acid motif

Driver, Kathy (Cathryn Helena Stanford); Balogun, Mohammed Olusegun; Toschi, Gianna; Verschoor, J.A. (Jan Adrianus), 1953-; Baird, Mark S.; Pilcher, Lynne A.

Please note that UPSpace will be unavailable from Friday, 2 May at 18:00 (South African Time) until Sunday, 4 May at 20:00 due to scheduled system upgrades. We apologise for any inconvenience this may cause and appreciate your understanding.

A biomimetic approach to the synthesis of a mycolic acid motif

Driver, Kathy (Cathryn Helena Stanford); Balogun, Mohammed Olusegun; Toschi, Gianna; Verschoor, J.A. (Jan Adrianus), 1953-; Baird, Mark S.; Pilcher, Lynne A.

URI: http://hdl.handle.net/2263/12794

Date: 2010-02

Abstract:

A new method for the stereoselective synthesis of the (R,R)-b-hydroxy-a-alkyl fatty acid fragment of mycolic acids, via an asymmetric anti-aldol reaction is reported. The ‘mycolic acid motif’ fragment was prepared in three steps and >98% ee.

Show full item record