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Browsing by UP Author "Pepper, Michael Sean"
Now showing items 1-20 of 176
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Pepper, Michael Sean (Health and Medical Publishing Group, 2020-12)In an ideal world, universal access to healthcare should be achievable; all COVID-19 patients should have access to therapies that improve outcomes. These include existing, repurposed and novel therapies. Novel therapies ...
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Ambele, Melvin Anyasi; Dhanraj, Priyanka; Giles, Rachel; Pepper, Michael Sean (MDPI Publishing, 2020-06-16)The formation of adipocytes during embryogenesis has been largely understudied. However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem cells which migrate from the mesoderm to their anatomical ...
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Nembaware, Victoria; African Genomic Medicine Training Initiative; Mulder, Nicola (Frontiers Media, 2019-12-20)The potential of genomic medicine in improving the quality of healthcare both at population and individual-level is well-recognized globally. However, successful adoption of genetic and genomic evidence into clinical ...
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Mabeta, Peaceful Lucy; Pepper, Michael Sean (Elsevier, 2015-02)Herein, we describe the effects of Taxol on endothelioma cell growth and migration in vitro and on vascular tumor growth in vivo. The effects of Taxol on endothelioma cell growth were determined using the crystal violet ...
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Ambele, Melvin Anyasi; Van Zyl, Andre; Pepper, Michael Sean; Van Heerden, Marlene B.; Van Heerden, Willem Francois Petrus (Frontiers Media, 2020-04-30)The lack of clinical biomarkers for head and neck cancer subtypes limits early diagnosis and monitoring of disease progression. This study investigates genetic alterations in clinically identical tumor, tumor-adjacent ...
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Kappala, S.S.; Alessandrini, Marco; Matlhako, T.; Beltchev, E.; Pool, Roger; Pepper, Michael Sean (Hindawi Publishing Corporation, 2017-11-07)Acute myeloid leukemia (AML) is characterized by proliferation of the myeloid lineage and accumulation of immature hematopoietic cells in the bone marrow and is typified by marked heterogeneity both in response to treatment ...
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Nothling-Slabbert, Melodie; Maister, B.; Botes, M.; Pepper, Michael Sean (Institute for Foreign and Comparative Law, UNISA, 2011)The article examines the application of the Consumer Protection Act 68 of 2008 in the health care context. Issues specifically considered are the introduction of no-fault liability and how this new development impacts on ...
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Pepper, Michael Sean; Dandara, Collet; De Vries, Jantina; Dhai, Amaboo; Labuschaigne, Melodie; Mnyongani, Freddy; Moodley, Keymanthri; Olckers, Antonel; Pope, Anne; Ramesar, Raj; Ramsay, Michele; Soodyall, Himla; Towers, Wayne (Academy of Science of South Africa, 2018-11-27)South Africa is home to one of the most genetically diverse populations in the world, which, combined with its high disease burden and high-quality infrastructure, makes our country a prime location for conducting genetics ...
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Jordaan, Donrich Willem; Woodrow, Christopher; Pepper, Michael Sean (Juta Law, 2009)Stem cell banking is a complex and controversial subject. There are currently three private stem cell banks in South Africa. At present, South Africa does not have a public stem cell bank. The de facto legal vacuum in which ...
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Barriers to implementing clinical pharmacogenetics testing in sub-Saharan Africa. A critical review Tata, Emiliene B.; Ambele, Melvin Anyasi; Pepper, Michael Sean (MDPI Publishing, 2020-08-26)Clinical research in high-income countries is increasingly demonstrating the coste ectiveness of clinical pharmacogenetic (PGx) testing in reducing the incidence of adverse drug reactions and improving overall patient ...
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Taylor, Janet; Anyango, Joseph Ochieng; Potgieter, Marnie; Kallmeyer, Karlien; Naidoo, Vinny; Pepper, Michael Sean; Taylor, J.R.N. (John Reginald Nuttall) (Wiley, 2015-08)Kafirin, the sorghum prolamin protein, like its maize homologue zein, can be made into micropatticles and films and potentially used as a biomaterial. Zein has good bio- and cytocompatibility. Kafirin could be advantageous ...
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Damerell, Victoria; Ambele, Melvin Anyasi; Salisbury, Shanel; Neumann-Mufweba, Alexis; Durandt, Chrisna; Pepper, Michael Sean; Prince, Sharon (Frontiers Media S.A., 2022-01-25)Sarcomas are highly aggressive cancers of mesenchymal origin whose clinical management is highly complex. This is partly due to a lack of understanding of the molecular mechanisms underpinning the transformation of ...
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Cancer stem cells in head and neck carcinomas : identification and possible therapeutic implications Wolmarans, Elize; Boy, S.C. (Sonja); Nel, Sulette; Mercier, Anne Elisabeth; Pepper, Michael Sean (Springer, 2017-11)The recurrence and/or lack of response of certain tumors to radio- and chemotherapy has been attributed to a small subpopulation of cells termed cancer stem cells (CSCs). CSCs have been identified in many tumors (including ...
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Myburgh, Renier; Hochfeld, Warren Ernst; Dodgen, Tyren Mark; Ker, James A.; Pepper, Michael Sean (Elsevier, 2012-03)Human genetic variation in the form of single nucleotide polymorphisms as well as more complex structural variations such as insertions, deletions and copy number variants, is partially responsible for the clinical ...
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Cell and gene therapies at the forefront of innovative medical care : implications for South Africa Pepper, Michael Sean; Alessandrini, A.; Pope, A.; Van Staden, W.; Green, Robin J. (Health and Medical Publishing Group, 2019-01)The fields of cell and gene therapy are moving rapidly towards providing innovative cures for incurable diseases. A current and highly topical example is immunotherapies involving T-cells that express chimeric antigen ...
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Pepper, Michael Sean (Health and Medical Publishing Group, 2010-05)No abstract available.
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Nakwa, Firdose Lambey; Sepeng, Letlhogonolo; Van Kwawegen, Alison; Thomas, Reenu; Seake, Karabo; Mogajane, Tshiamo; Ntuli, Nandi; Ondongo‑Ezhet, Claude; Kesting, Samantha; Kgwadi, Dikeledi Maureen; Kamanga, Noela Holo Bertha; Coetser, Annaleen; Van Rensburg, Jeanne; Pepper, Michael Sean; Velaphi, Sithembiso C. (BMC, 2023-01-31)BACKGROUND : In randomized clinical trials, therapeutic hypothermia (TH) has been shown to reduce death and/or moderate-to-severe disability in neonates with hypoxic ischemic encephalopathy (HIE) in high-income countries, while ...
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Mercier, Anne Elisabeth; Prudent, Renaud; Pepper, Michael Sean; De Koning, Leanne; Nolte, Elsie; Peronne, Lauralie; Nel, Marcel; Lafanechere, Laurence; Joubert, Annie M. (MDPI, 2021-01-29)The search for novel anti-cancer compounds which can circumvent chemotherapeutic drug resistance and limit systemic toxicity remains a priority. 2-Ethyl-3-O-sulphamoyl-estra-1,3,5(10)15- tetraene-3-ol-17one (ESE-15-one) ...
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Pathak, Arvind P.; Hochfeld, Warren Ernst; Goodman, Simon L.; Pepper, Michael Sean (Springer, 2008)Abundant preclinical and indirect clinical data have for several decades convincingly supported the notion that anti-angiogenesis is an effective strategy for the inhibition of tumor growth. The recent success achieved in ...
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Ambele, Melvin Anyasi; Robinson, Liam; Van Heerden, M.B. (Marlene); Pepper, Michael Sean; Van Heerden, Willem Francois Petrus (Elsevier, 2023-01)Odontogenic keratocysts (OKCs) are common cysts of odontogenic origin that usually occur as a single nonsyndromic cyst in isolation (sporadic) or as syndromic multiple cysts as a manifestation of naevoid basal cell carcinoma ...
Now showing items 1-20 of 176