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Browsing by Author "Mancama, Dalu"
Now showing items 1-7 of 7
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Chetty, Avashnee Shamparkesh; Vargha, Viktoria; Maity, Arjun; Moolman, Francis Sean; Rossouw, C.L. (Claire Louise); Anandjiwala, Rajesh; Boguslavsky, Lydia; Mancama, Dalu; Focke, Walter Wilhelm (Elsevier, 2013)Growing cells on 3D scaffolds is far superior to the conventional 2D monolayer culture method. In this study, a novel 3D thermoresponsive poly(propylene-g-N-isopropylacrylamide) (PP-g-PNIPAAm) nonwoven fabric (gNWF) was ...
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Birkholtz, Lyn-Marie; Coetzer, Theresa L.; Mancama, Dalu; Leroy, Didier; Alano, Pietro (Elsevier, 2016-09)The ability to target human-mosquito parasite transmission challenges global malaria elimination. However, it is not obvious what a transmission-blocking drug will look like; should it 1) target only parasite transmission ...
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Becker, John V.W.; Van der Merwe, Marina M.; Van Brummelen, A.C. (Anna Catharina); Pillay, Pamisha; Crampton, Bridget Genevieve; Mmutlane, Edwin M.; Parkinson, Chris; Van Heerden, Fanie R.; Crouch, Neil R.; Smith, Peter J.; Mancama, Dalu; Maharaj, Vinesh J. (BioMed Central, 2011)BACKGROUND: Anti-malarial drug resistance threatens to undermine efforts to eliminate this deadly disease. The resulting omnipresent requirement for drugs with novel modes of action prompted a national consortium ...
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Reader, Janette; Van der Watt, Mariette Elizabeth; Taylor, Dale; Le Manach, Claire; Mittal, Nimisha; Ottilie, Sabine; Theron, Anjo; Moyo, Phanankosi; Erlank, Erica; Nardini, Luisa; Venter, Nelius; Lauterbach, Sonja; Bezuidenhout, Belinda; Horatscheck, Andre; Van Heerden, Ashleigh; Spillman, Natalie J.; Cowell, Anne N.; Connacher, Jessica I.; Opperman, Daniel; Orchard, Lindsey M.; Llinas, Manuel; Istvan, Eva S.; Goldberg, Daniel E.; Boyle, Grant A.; Calvo, David; Mancama, Dalu; Coetzer, Theresa L.; Winzeler, Elizabeth A.; Duffy, James; Koekemoer, Lizette L.; Basarab, Gregory; Chibale, Kelly; Birkholtz, Lyn-Marie (Nature Publishing Group, 2021-01)Chemical matter is needed to target the divergent biology associated with the different life cycle stages of Plasmodium. Here, we report the parallel de novo screening of the Medicines for Malaria Venture (MMV) Pandemic ...
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Reader, Janette; Botha, M.E. (Mariette); Theron, Anjo; Lauterbach, Sonja B.; Rossouw, C.L. (Claire Louise); Engelbrecht, Dewaldt; Wepener, Melanie; Smit, Annél; Leroy, Didier; Mancama, Dalu; Coetzer, Theresa L.; Birkholtz, Lyn-Marie (BioMed Central, 2015)BACKGROUND : The discovery of malaria transmission-blocking compounds is seen as key to malaria elimination strategies and gametocyte-screening platforms are critical filters to identify active molecules. However, unlike ...
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Becker, John V.W.; Mtwisha, Linda; Crampton, Bridget Genevieve; Stoychev, Stoyan H.; Van Brummelen, Anna Catharina; Reeksting, Shaun Bernard; Louw, Abraham Izak; Birkholtz, Lyn-Marie; Mancama, Dalu (BioMed Central, 2010-04)BACKGROUND: Plasmodium falciparum, the causative agent of severe human malaria, has evolved to become resistant to previously successful antimalarial chemotherapies, most notably chloroquine and the antifolates. The ...
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Van der Watt, Mariette Elizabeth; Reader, Janette; Churchyard, Alisje; Nondaba, Sindisiwe; Lauterbach, Sonja B.; Niemand, Jandeli; Abayomi, Sijuade; Van Biljon, Riette Andele; Connacher, Jessica I.; Van Wyk, Roelof Daniel Jacobus; Le Manach, Claire; Paquet, Tanya; González Cabrera, Diego; Brunschwig, Christel; Theron, Anjo; Lozano-Arias, Sonia; Rodrigues, Janneth F.I.; Herreros, Esperanza; Leroy, Didier; Duffy, James; Street, Leslie J.; Chibale, Kelly; Mancama, Dalu; Coetzer, Theresa L.; Birkholtz, Lyn-Marie (Oxford University Press, 2018-05)OBJECTIVES : Novel chemical tools to eliminate malaria should ideally target both the asexual parasites and transmissible gametocytes. Several imidazopyridazines (IMPs) and 2-aminopyridines (2-APs) have been described as ...
Now showing items 1-7 of 7