Prevalence of hyperinsulinaemia among normozoospermic donors at Medfem Clinic, South Africa

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Authors

Bosman, Edolene
Esterhuizen, Aletta Dorothea
Rodrigues, Frederico Antonio
Becker, Piet J.
Hoffmann, Willem Abraham

Journal Title

Journal ISSN

Volume Title

Publisher

Wiley-Blackwell

Abstract

The aim of this study was to investigate the prevalence of hyperinsulinaemia in a group of normozoospermic donors and the influence of insulin levels on in vitro fertilisation (IVF) outcome. Fasting insulin and 2 h post-eating insulin levels were determined for a group of thirty-four sperm donors. They were divided into three groups according to their insulin profiles. The association between insulin levels and embryo quality was determined in a clinical study for the different groups. The prevalence of raised insulin in the donor group was 44% with a 95% confidence interval of 27.2% and 62.1%. Donors with normal insulin levels produced more good quality blastocysts in the IVF programme than those with abnormal insulin levels. These differences were not statistically significant (P = 0.8638). Embryo quality in an IVF programme may be influenced by male insulin levels. The role of insulin in male fertility needs to be investigated.

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Keywords

Embryo quality, Fasting insulin, Hyperinsulinaemia, Two hour post-eating insulin

Sustainable Development Goals

Citation

Bosman, E, Esterhuizen, AD, Rodrigues, FA, Becker, PJ & Hoffmann, WA 2013, 'Prevalence of hyperinsulinaemia among normozoospermic donors at Medfem Clinic, South Africa', Andrologia, vol. 45, no. 1, pp. 18-25.