Prevalence of hyperinsulinaemia among normozoospermic donors at Medfem Clinic, South Africa
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Date
Authors
Bosman, Edolene
Esterhuizen, Aletta Dorothea
Rodrigues, Frederico Antonio
Becker, Piet J.
Hoffmann, Willem Abraham
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley-Blackwell
Abstract
The aim of this study was to investigate the prevalence of hyperinsulinaemia in a group of normozoospermic donors and the influence of insulin levels on in vitro fertilisation (IVF) outcome. Fasting insulin and 2 h post-eating insulin levels were determined for a group of thirty-four sperm donors. They were divided into three groups according to their insulin profiles. The association between insulin levels and embryo quality was determined in a clinical study for the different groups. The prevalence of raised insulin in the donor group was 44% with a 95% confidence interval of 27.2% and 62.1%. Donors with normal insulin levels produced more good quality blastocysts in the IVF programme
than those with abnormal insulin levels. These differences were not
statistically significant (P = 0.8638). Embryo quality in an IVF programme may be influenced by male insulin levels. The role of insulin in male fertility needs to be investigated.
Description
Keywords
Embryo quality, Fasting insulin, Hyperinsulinaemia, Two hour post-eating insulin
Sustainable Development Goals
Citation
Bosman, E, Esterhuizen, AD, Rodrigues, FA, Becker, PJ & Hoffmann, WA 2013, 'Prevalence of hyperinsulinaemia among normozoospermic donors at Medfem Clinic, South Africa', Andrologia, vol. 45, no. 1, pp. 18-25.