Novel 3-trifluoromethyl-1,2,4-oxadiazole analogues of astemizole with multi-stage antiplasmodium activity and in vivo efficacy in a Plasmodium berghei mouse malaria infection model

dc.contributor.authorMambwe, Dickson
dc.contributor.authorKorkor, Constance M.
dc.contributor.authorMabhula, Amanda
dc.contributor.authorNgqumba, Zama
dc.contributor.authorCloete, Cleavon
dc.contributor.authorKumar, Malkeet
dc.contributor.authorBarros, Paula Ladeia
dc.contributor.authorLeshabane, Meta Kgaogelo
dc.contributor.authorCoertzen, Dina
dc.contributor.authorTaylor, Dale
dc.contributor.authorGibhard, Liezl
dc.contributor.authorNjoroge, Mathew
dc.contributor.authorLawrence, Nina
dc.contributor.authorReader, Janette
dc.contributor.authorMoreira, Diogo Rodrigo
dc.contributor.authorBirkholtz, Lyn-Marie
dc.contributor.authorWittlin, Sergio
dc.contributor.authorEgan, Timothy J.
dc.contributor.authorChibale, Kelly
dc.date.accessioned2023-02-24T08:08:34Z
dc.date.issued2022-12
dc.description.abstractPlease read abstract in the article.en_US
dc.description.departmentBiochemistryen_US
dc.description.departmentGeneticsen_US
dc.description.departmentMicrobiology and Plant Pathologyen_US
dc.description.departmentUP Centre for Sustainable Malaria Control (UP CSMC)en_US
dc.description.embargo2023-12-12
dc.description.librarianhj2023en_US
dc.description.urihttp://pubs.acs.org/loi/jmcmaren_US
dc.identifier.citationMambwe, D., Korkor, C.M., Mabhula, A. et al. 2022, 'Novel 3-trifluoromethyl-1,2,4-oxadiazole analogues of astemizole with multi-stage antiplasmodium activity and in vivo efficacy in a Plasmodium berghei mouse malaria infection model', Journal of Medicinal Chemistry, vol. 65, no. 24, pp. 16695–16715, doi : 10.1021/acs.jmedchem.2c01516.en_US
dc.identifier.issn0022-2623 (print)
dc.identifier.issn1520-4804 (online)
dc.identifier.other10.1021/acs.jmedchem.2c01516
dc.identifier.urihttps://repository.up.ac.za/handle/2263/89809
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Medicinal Chemistry, © 2022 American Chemical Society after peer review and technical editing by the publisher. [12 months embargo]en_US
dc.subjectAstemizoleen_US
dc.subjectRepositioningen_US
dc.subjectPlasmodium falciparumen_US
dc.subjectPlasmodium bergheien_US
dc.subjectHuman ether-á-go-go-related gene (hERG)en_US
dc.subjectLive-cell microscopyen_US
dc.titleNovel 3-trifluoromethyl-1,2,4-oxadiazole analogues of astemizole with multi-stage antiplasmodium activity and in vivo efficacy in a Plasmodium berghei mouse malaria infection modelen_US
dc.typePostprint Articleen_US

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