Synthesis, structural characterization, biological and in silico evaluation of halogenated Schiff bases as potential multifunctional agents

dc.contributor.authorNthehang, Tsholofelo S.
dc.contributor.authorWaziri, Ibrahim
dc.contributor.authorYusuf, Tunde Lewis
dc.contributor.authorOselusi, Samson Olaitan
dc.contributor.authorMuller, Alfred J
dc.date.accessioned2025-11-07T12:56:22Z
dc.date.available2025-11-07T12:56:22Z
dc.date.issued2026-02
dc.descriptionDATA AVAILABILITY : Data will be made available on request.
dc.description.abstractPlease read abstract in the article. HIGHLIGHTS • Three new halogen substituted Schiff bases (SB1, SB2, and SB3) were synthesized. • Detailed spectroscopic and theoretical investigations were carried out. • All compounds were tested for cyto-toxicity, antioxidant, and antibacterial. • Biological study results revealed SB1 and SB3 as the most potent across all the assays, with SB1 been more superior.
dc.description.departmentChemistry
dc.description.librarianhj2025
dc.description.sdgSDG-03: Good health and well-being
dc.description.sponsorshipThe University Research Center (URC) for a Postdoctoral research fellowship award; the South African National Research Foundation (NRF) for the M.Sc. bursary and the National Research Foundation (NRF) for covering running expenses.
dc.description.urihttps://www.elsevier.com/locate/molstr
dc.identifier.citationNthehang, T.S., Waziri, I., Yusuf, T.L. et al. 2026, 'Synthesis, structural characterization, biological and in silico evaluation of halogenated Schiff bases as potential multifunctional agents', Journal of Molecular Structure, vol. 1352, art. 144508, doi : 10.1016/j.molstruc.2025.144508.
dc.identifier.issn0022-2860 (print)
dc.identifier.issn1872-8014 (online)
dc.identifier.other10.1016/j.molstruc.2025.144508
dc.identifier.urihttp://hdl.handle.net/2263/105188
dc.language.isoen
dc.publisherElsevier
dc.rights© 2025 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.subjectHalogenated schiff bases
dc.subjectCytotoxicity
dc.subjectAntioxidant
dc.subjectAntibacterial
dc.subjectMolecular docking and dynamics
dc.titleSynthesis, structural characterization, biological and in silico evaluation of halogenated Schiff bases as potential multifunctional agents
dc.typeArticle

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