Missed rifampicin and isoniazid resistance by commercial molecular assays
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Date
Journal Title
Journal ISSN
Volume Title
Publisher
South African Medical Association
Abstract
Drug-resistant tuberculosis (TB) has poor outcomes unless resistance is detected early, ideally by commercially available molecular tests. We present a case of occult multidrug-resistant TB where both rifampicin and isoniazid resistance were missed by molecular testing and were only identified by phenotypic testing.
Description
Keywords
Tuberculosis (TB), Drug resistance, Diagnosis, Mutations, Molecular markers, Challenges, Drug-resistant tuberculosis (DR-TB)
Sustainable Development Goals
SDG-03: Good health and well-being
Citation
Richards, L., Ismail, F., Nel, J. et al. 2024, 'Missed rifampicin and isoniazid resistance by commercial molecular assays', South African Medical Journal, vol. 114, no. 7, pp. 14-16. https://doi.org/10.7196/SAMJ.2024.v114i7.1779.