Calcium and magnesium abnormalities in puppies with parvoviral enteritis
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Date
Authors
Mouton, Anneri
Celliers, Anri
Thompson, P.N. (Peter N.)
Mellanby, Richard J.
Schoeman, Johan P.
Journal Title
Journal ISSN
Volume Title
Publisher
American Veterinary Medical Association
Abstract
OBJECTIVE : To determine the association between ionized calcium (iCa) and/or total magnesium (tMg) and the development of sepsis and to investigate whether iCa or tMg is associated with mortality in puppies with canine parvoviral enteritis (CPE).
METHODS : 64 client-owned puppies with CPE were enrolled in this prospective cohort study. Serum iCa and tMg were measured daily from admission until death or discharge. Fifteen healthy client-owned puppies were used as controls.
RESULTS : Mean iCa concentrations of the CPE group on admission were significantly lower compared to the control group (1.35 mmol/L vs 1.52 mmol/L). Ionized calcium concentrations of nonsurvivors were significantly higher compared to survivors on day 2 but not on any other days. Puppies that were hypercalcemic on day 2 were also significantly more likely to die than normocalcemic puppies (OR, 10.7; 95% CI, 1.7 to 71). Ionized calcium was not associated with the development of sepsis on any day. In contrast, mean admission tMg concentrations of the CPE group were significantly higher compared to the control group (0.72 mmol/L vs 0.63 mmol/L). However, tMg concentrations were not significantly different between survivors and nonsurvivors nor were they associated with the development of sepsis on any day.
CONCLUSIONS : On admission, puppies with CPE had lower iCa and higher tMg compared to healthy puppies, and higher iCa a day after initiation of treatment was associated with increased odds of mortality.
CLINICAL RELEVANCE : The results of this study provide insight into calcium homeostasis in critically ill young dogs with CPE.
Description
Keywords
Ionized calcium (iCa), Total magnesium (tMg), Sepsis, Dogs (Canis familiaris), Canine parvoviral enteritis (CPE), Parvovirus, Magnesium, Systemic inflammatory response syndrome (SIRS), Calcium, SDG-03: Good health and well-being
Sustainable Development Goals
SDG-03:Good heatlh and well-being
Citation
Mouton, A., Celliers, A., Thompson, P.N. et al. 2025, 'Calcium and magnesium abnormalities in puppies with parvoviral enteritis', American Journal of Veterinary Research, vol. 86, no. 1, art. 187, pp. 1-8, doi : 10.2460/ajvr.24.07.0187.