Effect of metformin therapy and dietary supplements on semen parameters in hyperinsulinaemic males
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Date
Authors
Bosman, E.
Esterhuizen, A.D.
Rodrigues, Frederico Antonio
Becker, Piet J.
Hoffmann, W.A.
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Abstract
Previous reports indicated that hyperinsulinaemic men may exhibit a higher
percentage of poorly compacted DNA in their spermatozoa and less success in
an IVF programme (Andrologia, 45, 2003, 18; Andrologia, 2014, doi: 10.1111/
and.12227). The aim of this study was to investigate the effect of metformin
(Glucophage ) and antioxidant treatment (StaminoGro ) on the semen parameters
of hyperinsulinaemic men. Nineteen hyperinsulinaemic male patients were
treated for 3 months with metformin alone (Group A), and fifteen patients used
metformin in combination with the nutritional supplement (Group B). Combined
data of the two groups (pre- and post-treatment) differ significantly
regarding sperm morphology (P = 0.0003) and CMA3 (P < 0.0001) values. The
improvement in sperm morphology after treatment was similar for the two
respective groups (P < 0.05). The morphological normal sperm forms increased
from the mean percentage of 3.9 to 5.5% and from 4.2 to 5.5% for Group A
and B respectively. Where a combination of metformin and the supplement
were used (Group B), the combination treatment proved to be superior in
obtaining enhanced chromatin packaging quality although not statistically significant
(P = 0.5929) when compared with the metformin (Group A) group.
The chromatin packaging quality in Group B improved with 10% while the
improvement in Group A was approximately 8.3%. Therefore, infertile hyperinsulinaemic
men can benefit from metformin treatment and should be advised
on the use of nutritional supplements with antioxidant properties.
Description
Keywords
CMA3, Male hyperinsulinaemia, Metformin, Morphology, Nutritional supplement
Sustainable Development Goals
Citation
Bosman, E, Esterhuizen, AD, Rodrigues, FA, Becker, PJ & Hoffmann, WA 2015, 'Effect of metformin therapy and dietary supplements on semen parameters in hyperinsulinaemic males', Andrologia, vol. 47, no. 9, pp. 976-979.