Cardioprotective and renoprotective effects of melatonin and vitamin E on fluoride-induced hypertension and renal dysfunction in rats

dc.contributor.authorOyagbemi, Ademola Adetokunbo
dc.contributor.authorAjibade, Temitayo Olabisi
dc.contributor.authorEsan, Oluwaseun Olanrewaju
dc.contributor.authorAdetona, Moses Olusola
dc.contributor.authorAwoyomi, Omolola Victoria
dc.contributor.authorOmobowale, Temidayo Olutayo
dc.contributor.authorOla-Davies, Olufunke Eunice
dc.contributor.authorSaba, Adebowale Benard
dc.contributor.authorAdedapo, Adeolu Alex
dc.contributor.authorNkadimeng, Sanah Malomile
dc.contributor.authorMcGaw, Lyndy Joy
dc.contributor.authorKayoka-Kabongo, Prudence Ngalula
dc.contributor.authorYakubu, Momoh Audu
dc.contributor.authorNwulia, Evaristus
dc.contributor.authorOguntibeju, Oluwafemi Omoniyi
dc.date.accessioned2025-05-30T09:20:06Z
dc.date.available2025-05-30T09:20:06Z
dc.date.issued2024-02
dc.descriptionDATA AVAILABILITY : Data will be made available on request.
dc.description.abstractFluoride is an important toxicological and environmental toxicant that is implicated in diverse cardiorenal system dysfunctions via the induction of oxidative stress. The present study aims at evaluating the cardioprotective and renoprotective effects of melatonin and vitamin E on fluoride toxicity on biomarkers of oxidative stress, clinical pathology, and their molecular mechanism of action. Apparently healthy male rats of the Wistar strain (n = 50; 160 ± 7.5 g), were randomly distributed into five groups of ten animals per group as follows: Control, sodium fluoride (NaF, 25 mg/kg), NaF and melatonin 20 mg/kg i.p.; NaF and vitamin E 50 mg/kg p/o, NaF plus melatonin and vitamin E administered orally. NaF and melatonin were administered for fifteen consecutive days, whereas vitamin E was administered every 72 h. Blood pressure parameters, oxidative stress biomarkers, electrocardiography, histopathology, and immunohistochemical staining were performed. From this study, NaF intoxication provoked reduction in renal and cardiac systemic antioxidants, alterations of haemodynamic and electrocardiographic parameters, heightened blood urea nitrogen (BUN), creatinine, angiotensin converting enzyme, angiotensin 2 type 1 receptor, kidney injury molecule 1, interleukin 1 beta in the renal tissues, cardiac troponin, and nuclear kappa beta. However, the administration of either melatonin or vitamin E, and its combination mitigated high blood pressure, normalized electrocardiographic changes, abrogated biomarkers of oxidative stress, improved renal function, and attenuated inflammation. The combination of melatonin and vitamin E effectively mitigated cardiovascular and renal toxicities associated with fluoride intoxication through the prevention of cardio-renal dysfunction, oxidative stress, and inflammatory processes.
dc.description.departmentParaclinical Sciences
dc.description.librarianhj2025
dc.description.sdgSDG-03: Good health and well-being
dc.description.urihttps://link.springer.com/journal/580
dc.identifier.citationOyagbemi, A.A., Ajibade, T.O., Esan, O.O. et al. Cardioprotective and renoprotective effects of melatonin and vitamin E on fluoride-induced hypertension and renal dysfunction in rats. Comparative Clinical Pathology 33, 33–45 (2024). https://doi.org/10.1007/s00580-023-03519-5.
dc.identifier.issn1618-5641 (print)
dc.identifier.issn1618-565X (online)
dc.identifier.other10.1007/s00580-023-03519-5
dc.identifier.urihttp://hdl.handle.net/2263/102587
dc.language.isoen
dc.publisherSpringer
dc.rights© The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2023. The original publication is available at http://link.springer.comjournal/580.
dc.subjectFluoride
dc.subjectHypertension
dc.subjectMelatonin
dc.subjectRats
dc.subjectVitamin E
dc.titleCardioprotective and renoprotective effects of melatonin and vitamin E on fluoride-induced hypertension and renal dysfunction in rats
dc.typePostprint Article

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