Determining the relationship between severity of proteinuria and adverse maternal and neonatal outcomes in patients with preeclampsia

dc.contributor.authorJansen van Rensburg, Elizabeth
dc.contributor.authorSeopela, Louisa
dc.contributor.authorSnyman, Leon Cornelius
dc.date.accessioned2025-05-28T05:06:47Z
dc.date.available2025-05-28T05:06:47Z
dc.date.issued2024-12
dc.description.abstractOBJECTIVES : To investigate the relationship between the severity of proteinuria and adverse maternal and neonatal outcomes in patients with preeclampsia (PE). DESIGN : Prospective cohort study conducted in Gauteng, South Africa over 12 months. Patients with PE 18 years or older with singleton pregnancies were recruited. We included 248 in the final analysis. METHODS : Proteinuria was quantified using urine protein: creatinine ratio (UPCR). Preeclamptic patients’ outcomes were compared according to the UPCR values using regression models and by generating receiver operator characteristic (ROC) curves. Primary maternal outcomes were gestational age (GA) at diagnosis, GA at delivery, development of eclampsia, development of severe features and the need for more than one antihypertensive agent. Neonatal outcomes were admission to neonatal unit, 5-min APGAR score, need for ventilatory support and early neonatal death. RESULTS : There was a weak but significant negative correlation between GA at delivery and UPCR (Spearman’s correlation coefficient (SCC) − 0.191, p = 0.002). Most patients (77 %) required >1 agent to control their blood pressure, however there was no correlation between UPCR and the need for additional agents (SCC − 0.014, p = 0.828). There was a statistically significant correlation between UPCR and severe features, especially the development of haemolysis, elevated liver enzymes and low platelet (HELLP) syndrome (p = 0.005). There was no significant correlation between neonatal outcomes and UPCR. CONCLUSION : Severity of proteinuria correlated with earlier delivery and development of severe features, specifically HELLP syndrome and pulmonary oedema. There was no correlation between UPCR and requiring additional antihypertensive agents or neonatal outcomes.
dc.description.departmentObstetrics and Gynaecology
dc.description.librarianam2025
dc.description.sdgSDG-03: Good health and well-being
dc.description.urihttps://www.sciencedirect.com/journal/pregnancy-hypertension
dc.identifier.citationJansen van Rensburg, E., Seopela, L.B., Snyman, L.C. 2024, 'Determining the relationship between severity of proteinuria and adverse maternal and neonatal outcomes in patients with preeclampsia', Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, vol. 38, no. 101155, pp. 1-6. https://doi.org/10.1016/j.preghy.2024.101155.
dc.identifier.issn2210-7789 (print)
dc.identifier.issn2210-7797 (online)
dc.identifier.other10.1016/j.preghy.2024.101155
dc.identifier.urihttp://hdl.handle.net/2263/102548
dc.language.isoen
dc.publisherElsevier
dc.rights© 2024 The Author(s). This is an open access article under the CC BY-NC-ND license.
dc.subjectPreeclampsia
dc.subjectProteinuria
dc.subjectPregnancy
dc.subjectHypertension
dc.subjectMaternal outcome
dc.subjectNeonatal outcome
dc.titleDetermining the relationship between severity of proteinuria and adverse maternal and neonatal outcomes in patients with preeclampsia
dc.typeArticle

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
JansenVanRensburg_Determining_2024.pdf
Size:
949.11 KB
Format:
Adobe Portable Document Format
Description:
Article

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: