Cutaneous plasmacytoma with systemic metastases in a Cape serotine bat (Laephotis capensis)

dc.contributor.authorVan der Weyden, Louise
dc.contributor.authorAvenant, Alida
dc.contributor.authorO'Dell, Nicolize
dc.contributor.emailnicolize.odell@up.ac.zaen_US
dc.date.accessioned2024-12-13T04:20:54Z
dc.date.available2024-12-13T04:20:54Z
dc.date.issued2024-02-05
dc.descriptionDATA AVAILABILITY STATEMENT : All data underlying the results are available as part of the article, and no additional source data are required.en_US
dc.description.abstractDespite their relatively long life-spans, reports of neoplasia in bats are rare and are limited to a handful of cases. In this report, we describe a 2-year-old female wild Cape serotine bat (Laephotis capensis) that had been caught by a domestic cat and presented with a skin mass over the chest area. Histopathological analysis of a subsequent biopsy revealed proliferating sheets of neoplastic round cells, occasionally appearing to form packets, supported by a fine, fibrovascular stroma. Marked nuclear pleomorphism was seen, as well as a high mitotic count. Immunohistochemistry displayed positive labelling for MUM1 in the neoplastic cells. The diagnosis was extramedullary plasmacytoma (EMP); a neoplasm consisting of plasma cells derived from B lymphocytes. Due to a deteriorating condition, the bat was anaesthetised, and the mass was surgically removed two weeks later. However, the bat succumbed under the anaesthetic. Histopathological examination of the mass showed the same neoplastic cell population as observed in the biopsy; in addition, there was a locally extensive infiltration of neoplastic cells in the spleen and a mild presence of neoplastic cells in circulation. This is the first report of an EMP in a bat, and we compare the findings with that seen in dogs and cats.en_US
dc.description.departmentCentre for Wildlife Managementen_US
dc.description.departmentParaclinical Sciencesen_US
dc.description.librarianam2024en_US
dc.description.sdgSDG-03:Good heatlh and well-beingen_US
dc.description.sponsorshipFUNDING : L.v.d.W. was supported by the Wellcome Trust grant 108413/A/15/D.en_US
dc.description.urihttps://www.mdpi.com/journal/vetscien_US
dc.identifier.citationVan derWeyden, L.; Avenant, A.; O’Dell, N. Cutaneous Plasmacytoma with Systemic Metastases in a Cape Serotine Bat (Laephotis capensis). Veterinary Sciences 2024, 11, 72. https://DOI.org/10.3390/vetsci11020072.en_US
dc.identifier.issn2306-7381 (online)
dc.identifier.other10.3390/vetsci11020072
dc.identifier.urihttp://hdl.handle.net/2263/99992
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rights© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en_US
dc.subjectTumouren_US
dc.subjectLymphocyteen_US
dc.subjectB-cellen_US
dc.subjectPlasma cell tumouren_US
dc.subjectPlasmacytomaen_US
dc.subjectMUM-1en_US
dc.subjectMetastasisen_US
dc.subjectBatsen_US
dc.subjectCape serotine bat (Laephotis capensis)en_US
dc.subjectLaephotis capensisen_US
dc.subjectSDG-03: Good health and well-beingen_US
dc.titleCutaneous plasmacytoma with systemic metastases in a Cape serotine bat (Laephotis capensis)en_US
dc.typeArticleen_US

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