Phenotypic characterisation of bone marrow-derived haematopoietic stem/progenitor cells from HIV-infected individuals

dc.contributor.authorMistry, Priyal
dc.contributor.authorPotgieter, Joachim
dc.contributor.authorPepper, Michael Sean
dc.contributor.authorDurandt, Chrisna
dc.contributor.emailchrisna.durandt@up.ac.zaen_US
dc.date.accessioned2025-02-06T06:46:37Z
dc.date.issued2025-04
dc.descriptionDATA AVAILABILITY : Data is available from the corresponding author upon reasonable request.en_US
dc.description.abstractHuman immunodeficiency virus (HIV-1) infection remains a significant global public health concern, particularly in sub-Saharan Africa where the majority of HIV-1 infections are concentrated. People living with HIV (PLWH) often present with haematological abnormalities including alterations of the bone marrow (BM; dysplasia and cellularity changes) and most commonly cytopenias (anaemia, thrombocytopenia and neutropenia). From these clinical observations it is clear that HIV not only impacts the immune system but also the broader haematopoietic system. The underlying cause of HIV-mediated changes in the haematological system remains complex and multifactorial.en_US
dc.description.departmentHaematologyen_US
dc.description.departmentImmunologyen_US
dc.description.embargo2026-01-21
dc.description.librarianhj2024en_US
dc.description.sdgSDG-03:Good heatlh and well-beingen_US
dc.description.sponsorshipA National Health Laboratory Service (NHLS) Research Trust Award, the South African Medical Research Council (SAMRC) Extramural Unit for Stem Cell Research and Therapy, the University of Pretoria via the Institute for Cellular and Molecular Medicine and the National Research Foundation (NRF) Postgraduate Scholarship.en_US
dc.description.urihttps://link.springer.com/journal/12015en_US
dc.identifier.citationMistry, P., Potgieter, J.J.C., Pepper, M.S. et al. Phenotypic Characterisation of Bone Marrow-Derived Haematopoietic Stem/Progenitor Cells from HIV-Infected Individuals. Stem Cell Reviews and Reports 21, 900–903 (2025). https://doi.org/10.1007/s12015-024-10834-z.en_US
dc.identifier.issn1550-8943 (print)
dc.identifier.issn1558-6804 (online)
dc.identifier.other10.1007/s12015-024-10834-z
dc.identifier.urihttp://hdl.handle.net/2263/100559
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.rights© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025. The original publication is available at : http://link.springer.comjournal/12015.en_US
dc.subjectHuman immunodeficiency virus (HIV)en_US
dc.subjectPeople living with HIV (PLHIV)en_US
dc.subjectSub-Saharan Africa (SSA)en_US
dc.subjectLetteren_US
dc.subjectBone marrowen_US
dc.subjectHaematopoietic stem cells (HSCs)en_US
dc.subjectHaematopoietic stem and progenitor cells (HSPCs)en_US
dc.subjectSDG-03: Good health and well-beingen_US
dc.titlePhenotypic characterisation of bone marrow-derived haematopoietic stem/progenitor cells from HIV-infected individualsen_US
dc.typePostprint Articleen_US

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