Pectin a multifaceted biopolymer in the management of cancer : a review

dc.contributor.authorPicot-Allain, Marie Carene Nancy
dc.date.accessioned2024-07-10T10:18:19Z
dc.date.available2024-07-10T10:18:19Z
dc.date.issued2023-11-11*
dc.descriptionThe authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Carene Picot-Allain reports financial support was provided by Carnegie Corporation of New York through the Early Career Research Leader Fellowship Program at Future Africa, University of Pretoria. Carene PicotAllain reports financial support was provided by Capacity building competitive grant Training the Next Generation of Scientists for Africa provided by Carnegie Corporation of New York through the Regional Universities Forum for Capacity Building in Agriculture (RUFORUM).en_US
dc.descriptionACKNOWLEDGEMENT : We acknowledge the support provided by the Carnegie Corporation of New York through the Early Career Research Leader Fellowship Program at Future Africa, University of Pretoria. Support for this research was made possible through a capacity building competitive grant Training the Next Generation of Scientists for Africa provided by Carnegie Corporation of New York through the Regional Universities Forum for Capacity Building in Agriculture (RUFORUM).en_US
dc.description.abstractThis review article focuses on the multifaceted roles of pectin in cancer management, namely as an oncotherapeutic delivery vehicle and a pharmacological agent. Over the past decades, the potential of pectin as a novel therapeutical agent for the prevention and/or management of cancer has gained increasing interest. Pectin has been found to modulate different mechanisms involved in the onset and progression of carcinogenesis, such as galectin-3 inhibition, caspase-3- induced apoptosis, and autophagy. Elucidating the structure-activity relationship provides insight into the relationship between the structure of pectin and different mechanism/s. The bioactivity of pectin, with respect to its structure, was critically discussed to give a better insight of the relationship between the structure of the extracted pectin and the observed bioactive effects. The rhamnogalacturonan I part of the pectin chain was found to bind to galectin-3, associated with several cancer hallmarks. The anti-inflammatory and antioxidant potential of pectin were also described. The roles of pectin as a treatment enhancer and a drug delivery vehicle for oncotherapeutics were critically defined. The scientific findings presented in this paper are expected to highlight the potential and role of pectin recovered from various plant sources in preventing and managing cancer.en_US
dc.description.departmentConsumer Scienceen_US
dc.description.librarianam2024en_US
dc.description.sdgNoneen_US
dc.description.sponsorshipFUNDING : This research was funded by the Carnegie Corporation of New York through the Early Career Research Leader Fellowship Program at Future Africa, University of Pretoria, G 17-55192 and the Carnegie Corporation of New York through the Regional Universities Forum for Capacity Building in Agriculture (RUFORUM), grant ID RU/ 2022/ RI/ 08.en_US
dc.description.uriwww.cell.com/heliyonen_US
dc.identifier.citationPicot-Allain, M.C.N. & Neergheen, V.S. 2023, 'Pectin a multifaceted biopolymer in the management of cancer : a review', Heliyon, vol. 9, no. e22236, pp. 1-16. https://DOI.org/10.1016/j.heliyon.2023.e22236en_US
dc.identifier.issn2405-8440 (online)
dc.identifier.other10.1016/j.heliyon.2023.e22236
dc.identifier.urihttp://hdl.handle.net/2263/96906
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rights© 2023 The Authors. This is an open access article under the CC BY-NC-ND license.en_US
dc.subjectGalectin-3en_US
dc.subjectRhamnogalacturonan-Ien_US
dc.subjectAntioxidanten_US
dc.titlePectin a multifaceted biopolymer in the management of cancer : a reviewen_US
dc.typeArticleen_US

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