Carboxy-amidated AamAP1-lys has superior conformational flexibility and accelerated killing of gram-negative bacteria

dc.contributor.authorVan Wyk, Rosalind Jeanette
dc.contributor.authorSerem, June Cheptoo
dc.contributor.authorOosthuizen, Carel B.
dc.contributor.authorSemenya, Dorothy
dc.contributor.authorSerian, Miruna
dc.contributor.authorLorenz, Christian D.
dc.contributor.authorMason, A. James
dc.contributor.authorBester, Megan Jean
dc.contributor.authorGaspar, Anabella Regina Marques
dc.contributor.emailannabella.gaspar@up.ac.zaen_US
dc.date.accessioned2025-03-07T13:15:37Z
dc.date.available2025-03-07T13:15:37Z
dc.date.issued2025-02
dc.description.abstractPlease read abstract in the article.en_US
dc.description.departmentAnatomyen_US
dc.description.departmentBiochemistry, Genetics and Microbiology (BGM)en_US
dc.description.librarianhj2024en_US
dc.description.sdgSDG-03:Good heatlh and well-beingen_US
dc.description.sponsorshipThe South African Medical Research Council; the SA-UK Newton Fund Antibiotic Accelerator; the UK Materials and Molecular Modeling Hub for computational resources, which is partially funded by EPSRC and a BBSRC LIDo studentship.en_US
dc.description.urihttps://pubs.acs.org/journal/bichaw?ref=breadcrumben_US
dc.identifier.citationVan Wyk, R.J., Serem, J.C., Oosthuizen, C.B. et al. 2025, 'Carboxy-amidated AamAP1-lys has superior conformational flexibility and accelerated killing of gram-negative bacteria', Biochemistry, vol. 64, no. 4, pp. 841-859, doi : 10.1021/acs.biochem.4c00580.en_US
dc.identifier.issn0006-2960 (print)
dc.identifier.issn1520-4995 (online)
dc.identifier.other10.1021/acs.biochem.4c00580
dc.identifier.urihttp://hdl.handle.net/2263/101390
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.rights© 2025 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0.en_US
dc.subjectBacteriaen_US
dc.subjectBiofilmsen_US
dc.subjectMembranesen_US
dc.subjectOrganic reactionsen_US
dc.subjectPeptides and proteinsen_US
dc.subjectAntimicrobial peptide (AMP)en_US
dc.subjectC-terminal amidationen_US
dc.subjectSDG-03: Good health and well-beingen_US
dc.titleCarboxy-amidated AamAP1-lys has superior conformational flexibility and accelerated killing of gram-negative bacteriaen_US
dc.typeArticleen_US

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